iMagIng pulmonaRy Aspergillosis Using Gallium-68-dEferoxamine

Status: Recruiting
Location: See location...
Intervention Type: Other
Study Type: Interventional
Study Phase: Phase 2
SUMMARY

This is a single center open-label feasibility trial involving a single study visit for participants. The purpose of the study is to demonstrate the feasibility of \[68Ga\]Ga-DFO-B PET/CT (gallium-68-deferoxamine) for the visualization of pulmonary Aspergillus infection. The incidence of fungal infections is on the rise and are associated with significant mortality. Diagnosis pulmonary aspergillosis can be can be challenging, often requiring invasive tests such as bronchoscopy and lung tissue biopsies. Molecular imaging, specifically using radiolabeled siderophores like \[68Ga\]Ga-DFO-B, offers a non-invasive and location-specific approach to visualize and evaluate infections. Siderophores, critical for pathogenic microbes like Aspergillus fumigatus, play a role in iron acquisition. Preclinical studies with radiolabeled deferoxamine (DFO-B) demonstrated distinct accumulation at infection sites. Additionally, \[68Ga\]Ga-DFO-B PET/CT may differentiate between Aspergillus infection and cancer, making it a promising non-invasive diagnostic tool for pulmonary aspergillosis.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: f
View:

• The patient is at least 18 years old on the day of inclusion.

• The patient has suspected chronic pulmonary aspergillosis or ABPA.

• There is no significant interference with standard care and follow-up.

Locations
Other Locations
Netherlands
RadboudUMC
RECRUITING
Nijmegen
Contact Information
Primary
Laura Michon
laura.michon@radboudumc.nl
024 361 1111
Backup
Roger Brüggemann
roger.bruggemann@radboudumc.nl
024 361 1111
Time Frame
Start Date: 2025-05-01
Estimated Completion Date: 2026-05-01
Participants
Target number of participants: 10
Treatments
Experimental: Intervention
Patients will undergo a PET/CT scan at t=60 min after a single intravenous injection of a fixed dose of 100 MBq +/- 10% \[68Ga\]Ga-DFO-B (gallium-68-deferoxamine) which contains 100 µg deferoxamine (DFO-B).
Sponsors
Leads: Radboud University Medical Center

This content was sourced from clinicaltrials.gov