Progranulin in Ankylosing Spondylitis Patients: A Potential Biomarker?
Status: Recruiting
Location: See location...
Study Type: Observational
SUMMARY
In this study, we aimed to compare serum PGRN(progranulin) and TNF-α levels in AS patients with healthy controls and to determine the relationship between TNF-α inhibitor use and PGRN levels in AS patients.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 20
Maximum Age: 65
Healthy Volunteers: t
View:
• Between the ages of 20-65
• Signing the informed consent form
• Axial spondyloarthropathy diagnosis according to ASAS 2009 criteria
Locations
Other Locations
Turkey
Kırşehir Ahi Evran University
RECRUITING
Kırşehir
Contact Information
Primary
Şeyda Sultan ERASLAN, MD
sultaneraslan353@gmail.com
+905437676228
Backup
Nazife Kapan, Asst. Prof.
+905555839701
Time Frame
Start Date: 2026-01-15
Estimated Completion Date: 2026-08-30
Participants
Target number of participants: 160
Treatments
Patients with ankylosing spondylitis on TNF inhibitors
Participants will be seen at one time and serum PGRN and TNF levels will be measured from each of them by ELISA method.
patients with ankylosing spondylitis taking non-steroidal anti-inflammatory drugs
Participants will be seen at one time and serum PGRN and TNF levels will be measured from each of them by ELISA method.
Control
Participants will be seen at one time and serum PGRN and TNF levels will be measured from each of them by ELISA method.
Related Therapeutic Areas
Sponsors
Collaborators: Bilimsel Araştirma Projeleri Birimi, Istanbul Üniversitesi
Leads: Kirsehir Ahi Evran Universitesi