Characterization of the Nrf2 Response in Patients With Autosomal Dominant Polycystic Kidney Disease (ADPKD)
Status: Recruiting
Location: See location...
Study Type: Observational
SUMMARY
The purpose of this study is to characterize oxidative stress and the Nrf2 antioxidant response in early stages of Autosomal Dominant Polycystic Kidney Disease (ADPKD), while identifying candidate biomarkers.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Maximum Age: 30
Healthy Volunteers: t
View:
• ADPKD (based on Ravine et al. criteria)
• Class 1 B-E according to our imaging classification
• Male and female subjects 18 - 30 years of age, inclusive
• Estimated GFR\> 60 mL/min/m2 (CKD-EPI equation)
• Ability to provide written, informed consent.
• Male and female subjects 18 - 30 years of age, inclusive
• Estimated GFR\> 60 mL/min/m2 (CKD-EPI equation)
• Ability to provide written, informed consent.
Locations
United States
Minnesota
Mayo Clinic in Rochester
RECRUITING
Rochester
Contact Information
Primary
Ahmed Abdelfattah
Abdelfattah.Ahmed@mayo.edu
Backup
Maria V Irazabal, M.D., Ph.D
irazabalmira.maria@mayo.edu
507-884-5628
Time Frame
Start Date: 2019-10-04
Estimated Completion Date: 2025-12
Participants
Target number of participants: 40
Treatments
Patients with a previous diagnosis of ADPKD
Patients that have been diagnosed with ADPKD and meet the study's inclusion criteria
Healthy individuals as controls
Age and gender-matched healthy controls
Authors
Maria V. Irazabal
Related Therapeutic Areas
Sponsors
Collaborators: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Leads: Mayo Clinic