Summary: The purpose of this research is to prospectively test and validate the utility of Eko AI plus EMAS (Eko Murmur Analysis Software) in a real world, point-of-care setting.

Summary: The aim of the study is to compare platelet activation, activation of the coagulation and inflammation cascade during catheter ablation for atrial fibrillation using radiofrequency or pulsed-field energy. Patients with atrial fibrillation and standard indication for ablation according to the current guidelines will be randomized to ablation either using radiofrequency of pulsed-field energy. The e...

Summary: Cather ablation of non-paroxysmal atrial fibrillation is less effective compared to paroxysmal atrial fibrillation. Therefore, new techniques have been developed, such as high-density mapping to determine areas of focal and rotational activities. The aim is to assess the clinical efficacy of ablation focal and rotational activities, and to assess the relation between the areas of focal and rotatio...

Summary: The purpose of this research is to prospectively test and validate the utility of Eko AI plus EMAS murmur characterization in algorithm in a real world, point-of-care setting.

Objective: To evaluate the efficacy and safety of intensive management of blood pressure and cholesterol. Study design: This study is a multi-center, randomized and controlled clinical trial with four equally sized treatment groups: amlodipine/atorvastatin (5/10mg tablet); amlodipine/atorvastatin (5/20mg tablet); amlodipine/atorvastatin (5/10mg tablet)+allisartan (240mg/tablet); amlodipine/atorvastatin (5/20...

Summary: Health inequality and genetic disparity are a significant issue in the United Kingdom (UK). This study focuses on diseases that are associated with significant morbidity and mortality in the UK, and specifically examines the extent and basis of treatment failure in different patient populations. The vast majority of drug registration clinical trials have under-representation of ethnic minority pop...

Summary: The goal of this interventional clinical trial is compare between two different dose regimens of bisoprolol (beta-blocker) in CABG patients in terms of efficacy and safety.

Summary: The STOP AF First PAS is a prospective, global, multi-center, observational trial.

Summary: The objective of this study is to compare the efficacy of three different ablation strategies in patients with persistent AF: PV antral isolation alone (PVAI) PV antral isolation plus ablation of drivers (PVAI+drivers) PV antral isolation plus isolation of posterior wall (PVAI+box) All three strategies will employ contemporary catheter ablation technology using more efficient open irrigated tip co...

Summary: The STOP Persistent AF Post Approval Study (PAS) is a prospective, global, multicenter, observational trial.

Summary: The purpose of the study is to see if the Sentinel® Cerebral Protection System may prevent occurrence of stroke during an ablation procedure for atrial fibrillation (AF). The secondary purpose of this study is to study if cognitive function after AF ablation differs between those treated with the Sentinel cerebral protection device and those who do not receive the device.

Summary: Cryo Global Registry a prospective, global, multi-center, observational Post-Market Registry