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Effects of Lactobacillus plantarum PS128 on Children with Autism Spectrum Disorder in Taiwan: A Randomized, Double-Blind, Placebo-Controlled Trial.

Treatment Used: Lactobacillus plantarum PS128
Number of Patients: 0
MediFind Summary

Overview: The study aimed to determine the effect of Lactobacillus plantarum PS128 on boys aged 7 - 15 in Taiwan with Autism Spectrum Disorder

Conclusion: The results showed that PS128 improved disobedient behaviors and several elements were also improved.


This four-week, randomized, double-blind, placebo-controlled study investigated the effects of Lactobacillus plantarum PS128 (PS128) on boys with autism spectrum disorder (ASD) aged 7-15 in Taiwan. All subjects fulfilled the criteria for ASD diagnosis of DSM-V and the Autism Diagnostic Interview-Revised (ADI-R). Questionnaires used for the primary outcome measure include the Autism Behavior Checklist-Taiwan version (ABC-T), the Social Responsiveness Scale (SRS) and the Child Behavior Checklist (CBCL). The Swanson, Nolan, and Pelham-IV-Taiwan version (SNAP-IV) and the Clinical Global Impression-improvement (CGI-I) were used for the secondary outcome measure. The results showed that PS128 ameliorated opposition/defiance behaviors, and that the total score of SNAP-IV for younger children (aged 712) improved significantly compared with the placebo group. Additionally, several elements were also notably improved in the PS128 group after 28-day consumption of PS128. Further studies are needed to better clarify the effects of PS128 for younger children with ASD on broader symptoms.

Yen-wenn Liu, Min Liong, Yu-chu Chung, Hui-yi Huang, Wu-shun Peng, Yun-fang Cheng, Yu-siou Lin, Yu-yu Wu, Ying-chieh Tsai
Relevant Conditions

Autism Spectrum Disorder

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