Learn About Bullous Pemphigoid

What is the definition of Bullous Pemphigoid?

Bullous pemphigoid is a skin disorder characterized by blisters.

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What are the causes of Bullous Pemphigoid?

Bullous pemphigoid is an autoimmune disorder that occurs when the body's immune system attacks and destroys healthy body tissue by mistake. Specifically, the immune system attacks the proteins that attach the top layer of skin (epidermis) to the bottom layer of skin.

This disorder usually occurs in older persons and is rare in young people. Symptoms come and go. The condition often goes away within 5 years.

In some cases, the condition is triggered by a medicine.

What are the symptoms of Bullous Pemphigoid?

Most people with this disorder have itchy skin that may be severe. In most cases, there are blisters, called bullae.

  • Blisters are usually located on the arms, legs, or middle of the body. In rare cases, blisters can form in the mouth.
  • The blisters may break open and form open sores (ulcers).
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What are the current treatments for Bullous Pemphigoid?

Anti-inflammatory medicines called corticosteroids may be prescribed. They may be taken by mouth or applied to the skin. More powerful medicines may be used to help suppress the immune system if steroids do not work, or to allow lower steroid doses to be used.

Antibiotics in the tetracycline family may be useful. Niacin (a B complex vitamin) is sometimes given along with tetracycline.

Your provider may suggest self-care measures. These may include:

  • Applying anti-inflammatory creams to the skin
  • Using mild soaps and applying moisturizer to the skin after bathing
  • Protecting the affected skin from sun exposure and injury
Who are the top Bullous Pemphigoid Local Doctors?
Highly rated in

University of Iowa Health Care

University Of Iowa Hospitals & Clinics

200 Hawkins Dr 
Iowa City, IA 52242

Janet Fairley is a Dermatologist in Iowa City, Iowa. Dr. Fairley has been practicing medicine for over 41 years and is rated as an Elite doctor by MediFind in the treatment of Bullous Pemphigoid. She is also highly rated in 24 other conditions, according to our data. Her top areas of expertise are Bullous Pemphigoid, Pemphigus, Pemphigus Vulgaris, and Pemphigus Foliaceus. She is licensed to treat patients in Iowa and Wisconsin. Dr. Fairley is currently accepting new patients.

Highly rated in

University Of Rouen

Rouen, FR 76031

Pascal Joly is in Rouen, France. Joly is rated as an Elite expert by MediFind in the treatment of Bullous Pemphigoid. They are also highly rated in 22 other conditions, according to our data. Their top areas of expertise are Pemphigus, Pemphigus Foliaceus, Pemphigus Vulgaris, and Bullous Pemphigoid.

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Highly rated in

Emory Healthcare

Emory Clinic At 1525

1525 Clifton Rd Ne 
Atlanta, GA 30322

Ron Feldman is a Dermatologist in Atlanta, Georgia. Dr. Feldman has been practicing medicine for over 17 years and is rated as an Elite doctor by MediFind in the treatment of Bullous Pemphigoid. He is also highly rated in 8 other conditions, according to our data. His top areas of expertise are Bullous Pemphigoid, Cicatricial Pemphigoid, Pemphigus Foliaceus, and Pemphigus. He is licensed to treat patients in Georgia. Dr. Feldman is currently accepting new patients.

What is the outlook (prognosis) for Bullous Pemphigoid?

Bullous pemphigoid usually responds well to treatment. The medicine can often be stopped after several years. The disease sometimes returns after treatment is stopped.

What are the possible complications of Bullous Pemphigoid?

Skin infection is the most common complication.

Complications resulting from treatment may also occur, especially from taking corticosteroids.

When should I contact a medical professional for Bullous Pemphigoid?

Contact your provider if you have:

  • Unexplained blisters on your skin
  • An itchy rash that continues despite home treatment
Bullous pemphigoid - close-up of tense blisters
What are the latest Bullous Pemphigoid Clinical Trials?
Improving Clinical Trial Recruitment and Outcome Measures in Bullous Pemphigoid
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A Randomized, Part A Partial Blinded and Part B Double Blinded, Placebo-controlled 24-week Clinical Study to Evaluate the Efficacy and Safety of Nomacopan Therapy in Adult Patients With Bullous Pemphigoid Receiving Adjunct Oral Corticosteroid Therapy (ARREST-BP)
What are the Latest Advances for Bullous Pemphigoid?
Rapid Disease Control in First-Line Therapy-Resistant Mucous Membrane Pemphigoid and Bullous Pemphigoid with Omalizumab as Add-On Therapy: A Case Series Of 13 Patients.
Bullous pemphigoid associated with squamous cell lung carcinoma showing remarkable response to carboplatin-based chemotherapy:  a case report.
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A Novel Combined Use of Dupilumab for Treatment of Aggressive Refractory Pemphigus Vulgaris Complicated With Pulmonary Tuberculosis: A Case Report and the RNA-seq Analysis.
Who are the sources who wrote this article ?

Published Date : April 14, 2021
Published By : Elika Hoss, MD, Senior Associate Consultant, Mayo Clinic, Scottsdale, AZ. Also reviewed by David Zieve, MD, MHA, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team.

What are the references for this article ?

Dinulos JGH. Vesicular and bullous diseases. In: Dinulos JGH, ed. Habif's Clinical Dermatology. 7th ed. Philadelphia, PA: Elsevier; 2021:chap 16.

Peña S, Werth VP. Bullous pemphigoid. In: Lebwohl MG, Heymann WR, Berth-Jones J, Coulson IH, eds. Treatment of Skin Disease: Comprehensive Therapeutic Strategies. 5th ed. Philadelphia, PA: Elsevier; 2018:chap 33.