Learn About Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy

What is the definition of Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy?

Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy, usually called CADASIL, is an inherited condition that causes stroke and other impairments. This condition affects blood flow in small blood vessels, particularly cerebral vessels within the brain. The muscle cells surrounding these blood vessels (vascular smooth muscle cells) are abnormal and gradually die. In the brain, the resulting blood vessel damage (arteriopathy) can cause migraines, often with visual sensations or auras, or recurrent seizures (epilepsy).

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What are the causes of Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy?

Mutations in the NOTCH3 gene cause CADASIL. The NOTCH3 gene provides instructions for producing the Notch3 receptor protein, which is important for the normal function and survival of vascular smooth muscle cells. When certain molecules attach (bind) to Notch3 receptors, the receptors send signals to the nucleus of the cell. These signals then turn on (activate) particular genes within vascular smooth muscle cells.

How prevalent is Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy?

CADASIL is likely a rare condition; however, its prevalence is unknown.

Is Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy an inherited disorder?

This condition is inherited in an autosomal dominant pattern, which means one copy of the altered NOTCH3 gene in each cell is sufficient to cause the disorder.

Who are the top Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy Local Doctors?
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Highly rated in
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Université Paris Diderot

Paris, FR 

Eric Jouvent is in Paris, France. Jouvent is rated as an Elite expert by MediFind in the treatment of Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy. He is also highly rated in 9 other conditions, according to our data. His top areas of expertise are Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy, CACH Syndrome, Dementia, and Susac Syndrome.

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Université De Paris

Paris, FR 

Hugues Chabriat is in Paris, France. Chabriat is rated as an Elite expert by MediFind in the treatment of Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy. He is also highly rated in 13 other conditions, according to our data. His top areas of expertise are Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy, CACH Syndrome, Stroke, and Dementia.

 
 
 
 
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Elite
Highly rated in
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University Hospital

Institute For Stroke And Dementia Research 
Munich, BY, DE 

Marco Duering is in Munich, Germany. Duering is rated as an Elite expert by MediFind in the treatment of Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy. He is also highly rated in 11 other conditions, according to our data. His top areas of expertise are Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy, Dementia, Stroke, and Vascular Dementia.

What are the latest Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy Clinical Trials?
Virtual CST - A Collaborative Proof of Concept Study With FaceCog HK in Response to the Covid-19 Pandemic
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Natural History Study of CADASIL
Who are the sources who wrote this article ?

Published Date: April 01, 2019Published By: National Institutes of Health

What are the Latest Advances for Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy?
Multiple Sclerosis-Minimizing Errors in Radiological Diagnosis.
A Study of Seven Patients with Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CADASIL) in Eastern Taiwan: A Case Series with Literature Review.
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The spectrum of microvascular ultrastructural changes in the subpopulation of patients with migraine and cerebral white matter hyperintensities on MRI.