An Observational Study With Retrospective and Prospective Evaluations to Determine the Prevalence of Cerebrotendinous Xanthomatosis (CTX) Disorder in Juvenile Cataract Cases in Turkey

Status: Recruiting
Location: See all (36) locations...
Intervention Type: Procedure
Study Type: Observational
SUMMARY

Epidemiologic observational study. Study will include two phases: Retrospective cross-sectional phase: At this stage of the study, retrospective screenings are carried out at study sites and all juvenile cataract cases are planned to be determined. Prospective phase: At this stage of the study, identified juvenile cataract cases as a result of retrospective screenings will be called to be invited to the sites and blood samples will be obtained for the cholestanol tests for the cases that have given Informed Consent. This observational study is designed in two phases; retrospective and prospective. Retrospective part includes screening the patient database and / or patient files at ophthalmology clinics participating in the study and identifying patients diagnosed with idiopathic juvenile cataracts. The data of patients with idiopathic juvenile cataracts will be reviewed and the data of the patients meeting the inclusion/exclusion criteria will be recorded. Once this phase is completed, the prospective phase of the study will start and the patients meeting the criteria will be invited to the site to participate in the study. Current data will be collected from the patients who agree to participate in the study and the clinical status of the patients will be evaluated according to the Mignarri index. In addition, blood will be obtained from all patients to diagnose CTX disease. Blood samples will be sent to Duzen Laboratories in Ankara and analyzed for cholestanol.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 1
Healthy Volunteers: No
View:

• Providing the written informed consent form

• The patient should be diagnosed with idiopathic bilateral juvenile cataract

• Idiopathic bilateral juvenile cataract should be diagnosed while the patient must be take a day from one year (age)

• Syria ciziten who take their citizenship of Turkey could be enrolled to the study after signing of Informed Consent Form that translated to mother tongue by sworn translation office approved by ethic committee.

Locations
Other Locations
Turkey
Adana Başkent University School of Medicine
Not yet recruiting
Adana
Adana State Hospital
Recruiting
Adana
Çukurova University Medical Faculty Department of Ophtalmology
Recruiting
Adana
Ankara Training and Research Hospital
Recruiting
Ankara
Ankara University Medical Faculty Department of Ophtalmology
Recruiting
Ankara
Başkent University School of Medicine
Recruiting
Ankara
Dünya Göz Hospital
Recruiting
Ankara
Hacettepe University Medical Faculty Department of Ophtalmology
Recruiting
Ankara
Health Sciences University Ankara State Hospital
Recruiting
Ankara
SBU Gülhane Training and Research Hospital
Recruiting
Ankara
Ulucanlar Göz Training Hospital
Recruiting
Ankara
Akdeniz University Medical Faculty Department of Ophtalmology
Recruiting
Antalya
Bursa Yüksek İhtisas Training and Research Hospital
Recruiting
Bursa
Uludağ University Medical Faculty Department of Ophtalmology
Terminated
Bursa
Dicle University School of Medicine
Terminated
Diyarbakır
Fırat University School of Medicine
Recruiting
Elazığ
Osmangazi University Medical Faculty Department of Ophtalmology
Recruiting
Eskişehir
Gaziantep University Şahinbey Training and Research Hospital
Recruiting
Gaziantep
İstanbul Haseki Training and Research Hospital
Recruiting
Istanbul
İstanbul Health Sciences University Kanuni Sultan Süleyman Training and Research Hospital
Recruiting
Istanbul
Istanbul University Istanbul Medical Faculty Department of Ophtalmology
Recruiting
Istanbul
Marmara University Medical Faculty Department of Ophtalmology
Recruiting
Istanbul
Marmara University Pendik Training and Research Hospital
Not yet recruiting
Istanbul
Prof.Dr.N.Reşat Belger Beyoğlu Göz Training and Research Hospital
Recruiting
Istanbul
Dokuz Eylül University Medical Faculty Department of Ophtalmology
Recruiting
İzmir
Ege University Medical Faculty Department of Ophtalmology
Recruiting
İzmir
İzmir Dr. Behcet Uz Child Diseases and Surgery Training and Research Hospital
Recruiting
İzmir
Kayseri Training and Research Hospital
Recruiting
Kayseri
Kocaeli University School of medicine
Recruiting
Kocaeli
İnönü University School of Medicine
Terminated
Malatya
Mersin University Medical Faculty Department of Ophtalmology
Recruiting
Mersin
Sakarya University School of Medicine
Recruiting
Sakarya
Ondokuz Mayıs University School of Medicine
Recruiting
Samsun
Harran University Research and Application Hospital
Recruiting
Şanlıurfa
Karadeniz Technical University School of Medicine
Recruiting
Trabzon
Van 100. Yıl University Dursun Odabaş Medical Center
Recruiting
Van
Contact Information
Primary
Serdar Altinel
serdar.altinel@trpharm.com
00902123863149
Time Frame
Start Date: June 1, 2018
Estimated Completion Date: March 1, 2023
Participants
Target number of participants: 1000
Treatments
Epidemiologic observational study cohort
All patients over 1 year old diagnosed as idiopathic bilateral juvenile cataracts will be included in the study at the study sites.
Sponsors
Leads: TRPHARM
Collaborators: Klinar CRO, Düzen Laboratories Group

This content was sourced from clinicaltrials.gov

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