• Provision of signed and dated informed consent form

• Stated willingness to comply with all study procedures and availability (meets psychosocial criteria below) for the duration of the study

• Pregnant persons age 18 years and older

• Singleton pregnancy

• Absence of life-limiting genetic anomalies on microarray or karyotype on amniocentesis. Results by fluorescence in situ hybridization (FISH) will be acceptable if the patient is \> 26 weeks gestation

• Fetal echocardiogram with changes expected with CDH and no major structural cardiac defects (small ventricular septal defect (VSD)/atrial septal defect (ASD) may be included as they will not alter outcome and are not life-limiting)

• Left or Right CDH with liver up without presence of concomitant life-limiting anomalies.

• Gestational age for Left-CDH at enrollment prior to 29 weeks plus 6 days for O/E LHR \<30%; for Right-CDH with O/E LHR \<45% gestational age at enrollment prior to 29 weeks plus 6 days.

• Meets psychosocial criteria

• Willing to reside within 30 minutes of Children's Mercy Hospital Fetal Health Center and ability to maintain follow up appointments

• Patient has a support person (e.g. spouse, partner, friend, or parent) that is available to stay with her for the duration of the pregnancy.

• Willing to comply with restrictions of daily living including inability to exercise, have intercourse or return to work.