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Application of Positive Psychology Interventions in Individuals With Early-stage Cognitive Decline Related to Dementia: Their Impact on Cognitive and Brain Functioning

Status: Recruiting
Location: See location...
Intervention Type: Behavioral
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

This randomized study tests whether a new multicomponent Positive Psychology program can improve cognition and wellbeing in older adults at the earliest stages of dementia-related decline. About 128 participants with Subjective Cognitive Decline or Mild Cognitive Impairment will be enrolled. Half will be randomized to the Positive Psychology program and half to Treatment As Usual (TAU). The program consists of weekly, small-group online sessions for \ 24 weeks plus brief home practices. All participants (both arms) will complete questionnaires and cognitive tests at baseline, during treatment, post-treatment, and 9-month follow-up. Primary question: Do participants receiving the Positive Psychology program show better cognitive and brain-function outcomes than TAU at post-treatment and at 9 months? Secondary question: Are effects larger for SCD than MCI? No medicines are used and risks are minimal. If effective, this scalable, low-cost, non-pharmacological approach could complement usual care for people in very early cognitive decline.

Eligibility
Participation Requirements
Sex: All
Healthy Volunteers: f
View:

• Documented diagnosis of Subjective Cognitive Decline (SCD) or Mild Cognitive Impairment (MCI) according to clinical evaluation and site standard criteria.

Locations
Other Locations
Greece
Aristotle University of Thessaloniki
RECRUITING
Thessaloniki
Contact Information
Primary
Dimitra Vasileiou, M.Sc., PhD candidate
dvasilea@psy.auth.gr
+30 6987304327
Time Frame
Start Date: 2025-12-17
Estimated Completion Date: 2027-07
Participants
Target number of participants: 128
Treatments
Experimental: Positive Psychology Intervention
Multi-component Positive Psychology Intervention delivered online in small groups. One session per week (\~60 minutes) for about 16 weeks plus brief daily home practice (about 10 minutes). Core components include identifying and using character strengths and mindfulness. Facilitated by trained psychologist. No medicines are given.
Active_comparator: Treatment as Usual
Participants continue the treatment they already receive (e.g. cognitive training) from their usual providers. No additional structured positive psychology program is delivered by the study team. Assessments occur at the same time points as the experimental arm (baseline, mid-program, post-program, and follow-up).
Related Therapeutic Areas
Sponsors
Leads: Aristotle University Of Thessaloniki
Collaborators: Alzheimer Hellas

This content was sourced from clinicaltrials.gov