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Effect of Coeliac Plexus Versus Splanchnic Nerve Neurolysis in Pain Management With Upper Abdominal Malignancies

Status: Recruiting
Location: See location...
Intervention Type: Procedure
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

The goal of this clinical trial is to determine whether Neurolytic Splanchnic Nerve Block (NSNB) reduces pain in adults with upper abdominal malignancies. It will also evaluate the safety of Neurolytic Splanchnic Nerve Block (NSNB). The main questions it aims to answer are: Does NSNB reduce pain intensity compared to Neurolytic Coeliac Plexus Block (NCPB), as measured by the Visual Analog Scale (VAS)? What adverse effects do participants experience when receiving Neurolytic Splanchnic Nerve Block (NSNB)? Investigators will compare Neurolytic Splanchnic Nerve Block (NSNB) with Neurolytic Coeliac Plexus Block (NCPB) to determine which intervention provides more effective and safer pain relief. Participants will: * receive either NSNB or NCPB under fluoroscopic guidance * be monitored immediately and for 2 hours after the procedure for any complications Have their pain intensity recorded immediately after the procedure, and at 7 days, 1 month, and 3 months * be evaluated for quality-of-life using European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire - Core 3 (EORTC QLQ-C30) at 1 month and 3 months. * have their opioid consumption tracked throughout the study.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: f
View:

• Adult patient

• Both genders

• Diagnosed case of upper abdominal malignancy (pancreatic, gastric, hepatic, or biliary origin)

• Experiencing moderate to severe pain (≥5 on a 10 point visual analog scale)

• Patients who are conscious and can communicate

• No Contraindication for nerve block (e.g., coagulopathy, anticoagulant drugs)

Locations
Other Locations
Bangladesh
Bangladesh Medical University
RECRUITING
Dhaka
Time Frame
Start Date: 2026-05-01
Estimated Completion Date: 2027-01-31
Participants
Target number of participants: 44
Treatments
Active_comparator: Control group
Experimental: Intervention Group
Related Therapeutic Areas
Sponsors
Leads: Bangladesh Medical University

This content was sourced from clinicaltrials.gov