Overview: This report describes the case of a twelve year old male with severe hemosiderosis, disturbed bone marrow (BM) microenvironment which lead to experience graft failures.
Conclusion: After receiving three hematopoietic cell transplantation (HCT) the patients was able to receive complete donor chimerism and transfusion independence. Researchers assessed the risk associated with performing haploidentical HCT in older pediatric patients with severe hemosiderosis.
Matched related or unrelated donor allogeneic HCT has occasionally been applied in patients with severe CDA type II and proven to be curative. We report on the first patient with CDA to undergo haploidentical bone marrow transplantation with PT-CY. A 12-year-old boy with severe hemosiderosis, and a, consequently, disturbed BM microenvironment, developed recurrent graft failures and required salvage with two additional haploidentical HCTs. He achieved complete donor chimerism and transfusion independence after the third HCT. Our case underscores the risks associated with performing haploidentical HCT in older pediatric patients with CDA and severe chronic iron overload.