Clinical Trials

 

The NEUROlogically-impaired Extubation Timing Trial

Intervention Type: Procedure
Study Type: Interventional
Sponsors: Sunnybrook Health Sciences Centre, Canadian Institutes of Health Research (CIHR)
Participants: 332
Abstract
This trial in brain-injured patients will test which of the following will lead to better patient outcomes: (1) an airway management pathway consisting of daily assessments and removal of the breathing tube as soon as patients can breathe on their own and appear able to protect their airway; versus (2) the usual treatment patients would have received if they were not enrolled in this trial.
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Facilities
Nova Scotia Health Authority
Halifax, Canada
Centre hospitalier de l'Université de Montréal
Montréal, Canada
Vancouver General Hospital
Vancouver, Canada
L'Hôpital de l'Enfant-Jésus
Quebec City, Canada
Hôpital du Sacré-Coeur de Montréal
Montreal, Canada
Hamilton General Hospital
Hamilton, Canada
St. Michael's Hospital
Toronto, Canada
Ottawa Hospital
Ottawa, Canada
University of Alberta Hospital
Edmonton, Canada
Toronto Western Hospital
Toronto, Canada
Royal Columbian Hospital
New Westminster, Canada
Kingston General Hospital
Kingston, Canada
Sunnybrook Health Sciences Centre
Toronto, Canada
London Health Sciences Centre
London, Canada
Contacts
Primary
Venika Manoharan, HBSc
venika.manoharan@sunnybrook.ca
416-480-6100 ext 88136
Eligibilities
Sex: All
Minimum Age: 16
Healthy Volunteers: No
Inclusion Criteria:
- Age > 16 years
- Acute brain injury (subarachnoid hemorrhage, diffuse axonal injury, ischemic stroke, intracerebral hemorrhage, brain tumor, global cerebral anoxia/cardiac arrest, meningitis/encephalitis, cerebral abscess, epidural hematoma, subdural hematoma, seizure) that occurred within the previous 4 weeks
- Receiving mechanical ventilation via endotracheal tube for ≥ 48 hours
Exclusion Criteria:
- Quadriplegic
- Neuromuscular disease that will result in prolong need for mechanical ventilation, including but not limited to Guillain-Barre syndrome, cervical spinal cord injury, advanced multiple sclerosis
- Do-Not-Reintubate order in place
- Previously randomized in this trial
- Underlying pre-existing condition with life expectancy less than 6-months
- Current enrolment in an RCT that precludes NEURO-ETT co-enrollment

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