Factor XIII deficiency is a rare bleeding disorder. Researchers have identified an inherited form and a less severe form that is acquired during a person's lifetime.
Inherited factor XIII deficiency results from mutations in the F13A1 gene or, less commonly, the F13B gene. These genes provide instructions for making the two parts (subunits) of a protein called factor XIII. This protein plays a critical role in the coagulation cascade, which is a series of chemical reactions that forms blood clots in response to injury. After an injury, clots seal off blood vessels to stop bleeding and trigger blood vessel repair. Factor XIII acts at the end of the cascade to strengthen and stabilize newly formed clots, preventing further blood loss.
Inherited factor XIII deficiency affects 1 to 3 per million people worldwide. Researchers suspect that mild factor XIII deficiency, including the acquired form of the disorder, is underdiagnosed because many affected people never have a major episode of abnormal bleeding that would lead to a diagnosis.
Inherited factor XIII deficiency is considered to have an autosomal recessive pattern of inheritance, which means that it results when both copies of either the F13A1 gene or the F13B gene in each cell have mutations.
Ezio Zanon is in Padova, Italy. Zanon is rated as an Elite expert by MediFind in the treatment of Factor 13 Deficiency. He is also highly rated in 6 other conditions, according to our data. His top areas of expertise are Blood Clots, Hemophilia A, Factor 13 Deficiency, and Prothrombin Deficiency.
Mehran Karimi is in Shiraz, Islamic Republic of Iran. Karimi is rated as an Elite expert by MediFind in the treatment of Factor 13 Deficiency. They are also highly rated in 27 other conditions, according to our data. Their top areas of expertise are Thalassemia, Anemia, Hemolytic Anemia, and Congenital Hemolytic Anemia.
Akbar Dorgalaleh is in Tehran, Islamic Republic of Iran. Dorgalaleh is rated as an Elite expert by MediFind in the treatment of Factor 13 Deficiency. He is also highly rated in 14 other conditions, according to our data. His top areas of expertise are Factor 13 Deficiency, Blood Clots, Factor 5 Deficiency, and Factor 10 Deficiency.
Published Date:updated Last, January
Published By: National Institutes of Health