Felty syndrome is a disorder that includes rheumatoid arthritis, a swollen spleen, decreased white blood cell count, and repeated infections. It is rare.
Seropositive rheumatoid arthritis (RA); Felty's syndrome
The cause of Felty syndrome is unknown. It is more common in people who have had rheumatoid arthritis (RA) for a long time. People with this syndrome are at risk for infection because they have a low white blood cell count.
In most cases, people who have this syndrome are not getting recommended treatment for RA. They may need other medicines to suppress their immune system and reduce the activity of their RA.
Methotrexate may improve the low neutrophil count. The drug rituximab has been successful in people who do not respond to methotrexate.
Granulocyte-colony stimulating factor (G-CSF) may raise the neutrophil count.
Some people benefit from removal of the spleen (splenectomy).
Thomas Loughran is an Oncologist and a Hematologist Oncology doctor in Charlottesville, Virginia. Dr. Loughran has been practicing medicine for over 43 years and is rated as a Distinguished doctor by MediFind in the treatment of Felty Syndrome. He is also highly rated in 13 other conditions, according to our data. His top areas of expertise are Adult T-Cell Leukemia, Felty Syndrome, Leukemia, and Chronic T-Cell Leukemia. He is licensed to treat patients in Pennsylvania and Virginia. Dr. Loughran is currently accepting new patients.
Vadim Gorodetskiy is in Moscow, Russian Federation. Gorodetskiy is rated as a Distinguished expert by MediFind in the treatment of Felty Syndrome. He is also highly rated in 11 other conditions, according to our data. His top areas of expertise are Felty Syndrome, Sjogren Syndrome, Dry Mouth, and Diffuse Large B-Cell Lymphoma DLBCL.
Amanda May is an Oncologist and a Hematologist Oncology doctor in Thomasville, Georgia. Dr. May has been practicing medicine for over 25 years and is rated as a Distinguished doctor by MediFind in the treatment of Felty Syndrome. She is also highly rated in 41 other conditions, according to our data. Her top areas of expertise are Felty Syndrome, Pleuropulmonary Blastoma, Lung Cancer, and Paget Disease of the Breast. She is licensed to treat patients in Georgia. Dr. May is currently accepting new patients.
Without treatment, infections may continue to occur.
RA is likely to get worse.
Treating the RA, however, should improve Felty syndrome.
You may have infections that keep coming back.
Some people with Felty syndrome have increased numbers of large granular lymphocytes, also called LGL leukemia. This will be treated with methotrexate in many cases.
Call your health care provider if you develop symptoms of this disorder.
Prompt treatment of RA with currently recommended medicines markedly decreases the risk of developing Felty syndrome.
Published Date : May 02, 2021
Published By : Diane M. Horowitz, MD, Rheumatology and Internal Medicine, Northwell Health, Great Neck, NY. Review provided by VeriMed Healthcare Network. Also reviewed by David Zieve, MD, MHA, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team.
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