Learn About Fibrous Dysplasia

What is the definition of Fibrous Dysplasia?

Fibrous dysplasia is a bone disease that destroys and replaces normal bone with fibrous bone tissue. One or more bones can be affected.

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What are the alternative names for Fibrous Dysplasia?

Inflammatory fibrous hyperplasia; Idiopathic fibrous hyperplasia; McCune-Albright syndrome

What are the causes of Fibrous Dysplasia?

Fibrous dysplasia usually occurs in childhood. Most people have symptoms by the time they are 30 years old. The disease occurs more often in females.

Fibrous dysplasia is linked to a problem with genes (gene mutation) that control bone-producing cells. The mutation occurs when a baby is developing in the womb. The condition is not passed from parent to child.

What are the symptoms of Fibrous Dysplasia?

Symptoms may include any of the following:

  • Bone pain
  • Bone sores (lesions)
  • Endocrine (hormone) gland problems
  • Fractures or bone deformities
  • Unusual skin color (pigmentation), which occurs with McCune-Albright syndrome

The bone lesions may stop when the child reaches puberty.

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What are the current treatments for Fibrous Dysplasia?

There is no cure for fibrous dysplasia. Bone fractures or deformities are treated as needed. Hormone problems will need to be treated.

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What is the outlook (prognosis) for Fibrous Dysplasia?

The outlook depends on the severity of the condition and the symptoms that occur.

What are the possible complications of Fibrous Dysplasia?

Depending on the bones that are affected, health problems that may result include:

  • If skull bone is affected, there can be vision or hearing loss
  • If a leg bone is affected, there can be difficulty walking and joint problems such as arthritis
When should I contact a medical professional for Fibrous Dysplasia?

Contact your provider if your child has symptoms of this condition, such as repeated bone fractures and unexplained bone deformity.

Specialists in orthopedics, endocrinology, and genetics may be involved in your child's diagnosis and care.

How do I prevent Fibrous Dysplasia?

There is no known way to prevent fibrous dysplasia. Treatment aims to prevent complications, such as recurrent bone fractures, to help make the condition less severe.

Anterior skeletal anatomy
What are the latest Fibrous Dysplasia Clinical Trials?
Elucidating Mechanisms of Pain in Adolescent and Adult Fibrous Dysplasia Patients
Summary: Pain remains a common and frequently debilitating symptom, particularly during adulthood of Fibrous Dysplasia/McCune-Albright Syndrome (FD/MAS). For many FD/MAS patients, the amount of pain perceived is not commensurate with the level of detectable musculoskeletal pathology. Using a combination of clinical and biological assessments, this investigation aims to understand what drives pain in FD/MAS...
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Identification of Mutations That Lead to Cherubism in Families and Isolated Cases and Studies of Cellular and Molecular Mechanisms
Summary: The goal of this research study is to identify genes and regulatory elements on chromosomes that cause cherubism. Together with the investigators collaborators the investigators also study blood samples and tissue samples from patients to learn about the processes that lead to this disorder. The long-term goal of researchers involved in this study is to find mechanisms to slow down bone resorption...
What are the Latest Advances for Fibrous Dysplasia?
Effects of zoledronic acid therapy in fibrous dysplasia of bone: a single-center experience.
Summary: Effects of zoledronic acid therapy in fibrous dysplasia of bone: a single-center experience.
Inhibition of IL-6 in the treatment of fibrous dysplasia of bone: The randomized double-blind placebo-controlled TOCIDYS trial.
Summary: Inhibition of IL-6 in the treatment of fibrous dysplasia of bone: The randomized double-blind placebo-controlled TOCIDYS trial.
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Navigation-guided nasal endoscopic surgery for acute vision loss caused by fibrous dysplasia: a case report and review of literatures.
Summary: Navigation-guided nasal endoscopic surgery for acute vision loss caused by fibrous dysplasia: a case report and review of literatures.
Who are the sources who wrote this article ?

Published Date: December 12, 2021
Published By: Neil K. Kaneshiro, MD, MHA, Clinical Professor of Pediatrics, University of Washington School of Medicine, Seattle, WA. Also reviewed by David Zieve, MD, MHA, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team.

What are the references for this article ?

Nadol JB, Quesnel AM. Otologic manifestations of systemic disease. In: Flint PW, Francis HW, Haughey BH, et al, eds. Cummings Otolaryngology: Head and Neck Surgery. 7th ed. Philadelphia, PA: Elsevier; 2021:chap 151.

Nicolai P, Mattavelli D, Castlenuovo P. Benign tumors of the sinonasal tract. In: Flint PW, Francis HW, Haughey BH, et al, eds. Cummings Otolaryngology: Head and Neck Surgery. 7th ed. Philadelphia, PA: Elsevier; 2021:chap 50.

Shiflett JM, Caroll BW. Skull lesions in children. In: Winn HR, ed. Youmans and Winn Neurological Surgery. 8th ed. Philadelphia, PA: Elsevier; 2023:chap 245.

Toy PC, Heck RK. Benign bone tumors and nonneoplastic conditions simulating bone tumors. In: Azar FM, Beaty JH, eds. Campbell's Operative Orthopaedics. 14th ed. Philadelphia, PA: Elsevier; 2021:chap 25.