Fragile XE Syndrome

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Social Avoidance Emerges in Infancy and Persists into Adulthood in Fragile X Syndrome.

Treatment Used: Social avoidance
Number of Patients: 191
MediFind Summary

Overview: This article discusses the prevalence of social avoidance in fragile X syndrome.

Conclusion: 81% of males with fragile X syndrome showed social avoidance, which started as a baby, became worse across childhood, and stabilized through teens and early adulthood.


Fragile X syndrome (FXS) is characterized by both social approach and social avoidance. However, the age of emergence and developmental trajectory of social avoidance has not been examined. This study investigates the longitudinal developmental trajectory and dynamic nature of social avoidance in males with FXS from infancy through young adulthood (n = 191). Multiple facets of social avoidance were collected using the Social Avoidance Scale (Roberts et al. 2007, 2009). Overall, 81% of males with FXS displayed social avoidance, which emerged during infancy, increased in severity across childhood, and stabilized through adolescence and early adulthood. An exaggerated "warm up" effect was also observed in FXS. This study delineates the complex profile of social avoidance, a common and impairing behavioral feature of FXS.

Jane Roberts, Hayley Crawford, Abigail Hogan, Amanda Fairchild, Bridgette Tonnsen, Alexis Brewe, Shannon O'connor, Douglas Roberts, Leonard Abbeduto

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