Learn About Fraser Syndrome

What is the definition of Fraser Syndrome?

Fraser syndrome is a rare disorder that affects development starting before birth. Characteristic features of this condition include eyes that are completely covered by skin and usually malformed (cryptophthalmos), fusion of the skin between the fingers and toes (cutaneous syndactyly), and abnormalities of the genitalia and the urinary tract (genitourinary anomalies). Other tissues and organs can also be affected. Depending on the severity of the signs and symptoms, Fraser syndrome can be fatal before or shortly after birth; less severely affected individuals can live into childhood or adulthood.

Save information for later
Sign Up
What are the causes of Fraser Syndrome?

Mutations in the FRAS1, FREM2, or GRIP1 gene can cause Fraser syndrome. FRAS1 gene mutations are the most common cause, accounting for about half of cases of Fraser syndrome. FREM2 and GRIP1 gene mutations are each found in a small percentage of cases.

How prevalent is Fraser Syndrome?

Fraser syndrome affects an estimated 1 in 200,000 newborns. The condition occurs in approximately 1 in 10,000 fetuses that do not survive to birth.

Is Fraser Syndrome an inherited disorder?

This condition is inherited in an autosomal recessive pattern, which means both copies of the gene in each cell have mutations. The parents of an individual with an autosomal recessive condition each carry one copy of the mutated gene, but they typically do not show signs and symptoms of the condition.

Who are the top Fraser Syndrome Local Doctors?
Elite
Highly rated in
7
conditions

Simon Fraser University Burnaby

Department Of Biological Sciences, Simon Fraser University 
Burnaby, BC, CA V5A1S

Bernard Crespi is in Burnaby, Canada. Crespi is rated as an Elite expert by MediFind in the treatment of Fraser Syndrome. He is also highly rated in 7 other conditions, according to our data. His top areas of expertise are Fraser Syndrome, Autism Spectrum Disorder, Schizophrenia, and Williams Syndrome.

Elite
Highly rated in
4
conditions

BC Centre For Excellence In HIV/AIDS

Vancouver, BC, CA 

Bohdan Nosyk is in Vancouver, Canada. Nosyk is rated as an Elite expert by MediFind in the treatment of Fraser Syndrome. He is also highly rated in 4 other conditions, according to our data. His top areas of expertise are Fraser Syndrome, Opioid Use Disorder, HIV/AIDS, and Adult T-Cell Leukemia.

 
 
 
 
Learn about our expert tiers
Learn more
Elite
Highly rated in
6
conditions

British Columbia Centre For Excellence In HIV/AIDS

Vancouver, BC, CA 

Robert Hogg is in Vancouver, Canada. Hogg is rated as an Elite expert by MediFind in the treatment of Fraser Syndrome. He is also highly rated in 6 other conditions, according to our data. His top areas of expertise are Fraser Syndrome, HIV/AIDS, Syphilis, and Hepatitis C.

What are the latest Fraser Syndrome Clinical Trials?
Match to trials
Find the right clinical trials for you in under a minute
Get started
Who are the sources who wrote this article ?

Published Date: June 01, 2014Published By: National Institutes of Health

What are the Latest Advances for Fraser Syndrome?
Risks and Benefits of Chimeric Antigen Receptor T-Cell (CAR-T) Therapy in Cancer: A Systematic Review and Meta-Analysis.
FAST Club: The Impact of a Physical Activity Intervention on Executive Function in Children With Fetal Alcohol Spectrum Disorder.
Tired of the same old research?
Check Latest Advances