Effects of Ziltivekimab Versus Placebo on Heart Failure Symptoms and Physical Function in Patients With Heart Failure With Mildly Reduced or Preserved Ejection Fraction and Systemic Inflammation
Status: Recruiting
Location: See all (232) locations...
Intervention Type: Drug
Study Type: Interventional
Study Phase: Phase 3
SUMMARY
The study is being done to see if ziltivekimab can be used to treat participants living with heart failure and inflammation. Participants will either get ziltivekimab (active medicine) or placebo (inactive substance that looks like the study medicine but does not contain any medicine). The treatment participants get is decided by chance. Participant's chance of getting ziltivekimab or placebo is the same. Ziltivekimab is not yet approved in any country or region in the world. It is a new medicine that doctors cannot prescribe. The study is expected to last for up to 1 year and 4 months.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: f
View:
• Serum high-sensitivity C-reactive protein (hs-CRP) greater than or equal to 2 milligrams per liter (mg/L) at screening (visit 1)
• Disease specific - cardiovascular:
• N-terminal-pro-brain natriuretic peptide (NT-proBNP) greater than or equal to 225 picograms per milliliter (pg/mL) (375 pg/mL for participants with atrial fibrillation/flutter) at screening
• Diagnosis of heart failure (New York heart association (NYHA) Class II-III)
• Left ventricular ejection fraction (LVEF) greater than 40 percent documented by echocardiography within 12 months prior to or at screening (visit 1). The LVEF must be documented in medical records and the most recent measurement must be used to determine eligibility with no interim event signalling potential deterioration in ejection fraction (example myocardial infarction (MI) or heart failure (HF) hospitalisation)
• Structural heart disease and/or functional heart disease documented by echocardiography within 12 months prior to or at screening (visit 1) showing at least one of the following:
‣ Left atrial (LA) volume index greater than 34 milliliter per square meter (mL/m\^2)
⁃ LA diameter greater than or equal to 3.8 centimeter (cm)
⁃ LA length greater than or equal to 5.0 cm
⁃ LA area greater than or equal to 20 square centimeter (cm\^2)
⁃ LA volume greater than or equal to 55 milliliter (mL)
⁃ Intraventricular septal thickness greater than or equal to 1.1 cm
⁃ Posterior wall thickness greater than or equal to 1.1 cm
⁃ LV mass index greater than or equal to 115 gram per square meter (g/m\^2) in men or greater than or equal to 95 g/m\^2 in women
• h) E/e' (mean septal and lateral) greater than or equal to 10 i) e' (mean septal and lateral) less than 9 centimeter per second (cm/s)
• No heart failure hospitalisations or urgent heart failure visits between screening and randomisation
• Able to perform the 6-minute walk test (6MWT) at screening with a minimum distance of 100 metres
• Kansas City Cardiomyopathy Questionnaire (KCCQ) clinical summary score lesser than 80 at screening
Locations
United States
Alabama
Advanced Cardiovascular, LLC
COMPLETED
Alexander City
Eastern Shore Rsrch Inst, LLC
ACTIVE_NOT_RECRUITING
Fairhope
Arkansas
Cardiology & Medicine Clinic
COMPLETED
Little Rock
California
Valley Clinical Trials, Inc.
ACTIVE_NOT_RECRUITING
Northridge
Valley Clinical Trials, Inc.
RECRUITING
Northridge
UCI Health
COMPLETED
Orange
South California Heart Spc
ACTIVE_NOT_RECRUITING
Pasadena
Florida
Clearwater Cardiovascular Consultants
COMPLETED
Largo
Clearwater Cardiovascular Consultants
RECRUITING
Largo
Ocala Cardiovascular Research
ACTIVE_NOT_RECRUITING
Ocala
Ormond Beach Clinical Research
ACTIVE_NOT_RECRUITING
Ormond Beach
St Johns Ctr Clin Rsch-St. Aug
ACTIVE_NOT_RECRUITING
Saint Augustine
Georgia
GA Arrhythmia Cons & Rsch Inst
ACTIVE_NOT_RECRUITING
Macon
Velocity Clin Rsrch - Savannah
COMPLETED
Savannah
Illinois
Chicago Medical Research LLC
COMPLETED
Hazel Crest
Kentucky
UofL Health Care Outpatient
ACTIVE_NOT_RECRUITING
Louisville
Maryland
Maryland Cardiovascular Specialists - Baltimore
COMPLETED
Baltimore
MD Medical Research
COMPLETED
Oxon Hill
Michigan
Cardio and Vascular Assoc-CAVA
ACTIVE_NOT_RECRUITING
Bloomfield Hills
Millennium Cardiology
ACTIVE_NOT_RECRUITING
Farmington Hills
Missouri
Kansas City VA Medical Center
COMPLETED
Kansas City
Kansas City VA Medical Center
RECRUITING
Kansas City
Washington University
ACTIVE_NOT_RECRUITING
St Louis
North Carolina
University Of North Carolina At Chapel Hill
ACTIVE_NOT_RECRUITING
Chapel Hill
Nevada
Renown Regional Medical Center
ACTIVE_NOT_RECRUITING
Reno
New York
Long Island Cardiovascular Consultants PC
COMPLETED
Lake Success
Mount Sinai Hosp at NYC
ACTIVE_NOT_RECRUITING
New York
Northwell Health Phys Cardio
ACTIVE_NOT_RECRUITING
Riverhead
Pennsylvania
AMS Cardiology
ACTIVE_NOT_RECRUITING
Horsham
Univ of Pennsylvania Hospital
ACTIVE_NOT_RECRUITING
Philadelphia
Texas
PharmaTex Research
RECRUITING
Amarillo
PharmaTex Research
ACTIVE_NOT_RECRUITING
Amarillo
University of Texas Southwestern Medical Center
ACTIVE_NOT_RECRUITING
Dallas
David Turbay, MD, PLLC
ACTIVE_NOT_RECRUITING
El Paso
Private Practice Leadership LLC.
COMPLETED
Katy
Clinical Advancement Center
ACTIVE_NOT_RECRUITING
San Antonio
Clinical Advancement Ctr, PLLC
NOT_YET_RECRUITING
San Antonio
Sherman Clinical Research
ACTIVE_NOT_RECRUITING
Sherman
Northwest Heart Center
ACTIVE_NOT_RECRUITING
Tomball
Virginia
Sentara Health Research Center
COMPLETED
Norfolk
Virginia Commonwealth University
COMPLETED
Richmond
Other Locations
Argentina
Centro Medico Dra. Laura Maffei e Investigacion Clínica Apli
ACTIVE_NOT_RECRUITING
Buenos Aires
CIPREC Pueyrredon
RECRUITING
Buenos Aires
Instituto de Investigaciones Clinicas Quilmes SRL
ACTIVE_NOT_RECRUITING
Buenos Aires
CIPREC Arenales
COMPLETED
Caba
Cardiología Palermo
ACTIVE_NOT_RECRUITING
City Of Buenos Aires
Sanatorio Esperanza
ACTIVE_NOT_RECRUITING
Esperanza, Santa Fe
Centro Médico CIMEL
RECRUITING
Lanús Este
Consultorio Integral de Atención al Diabético
ACTIVE_NOT_RECRUITING
Morón
Centro Cardiovascular Salta
RECRUITING
Salta
Investigaciones Clinicas Tucuman
ACTIVE_NOT_RECRUITING
San Miguel De Tucumán, Tucumán.
Australia
Ballarat Base Hospital
ACTIVE_NOT_RECRUITING
Ballarat
Ballarat Base Hospital
NOT_YET_RECRUITING
Ballarat
The Prince Charles Hospital
ACTIVE_NOT_RECRUITING
Brisbane
The Prince Charles Hospital
RECRUITING
Brisbane
The Cardiologists Pty Ltd
NOT_YET_RECRUITING
Epping
The Cardiologists Pty Ltd
ACTIVE_NOT_RECRUITING
Epping
Canberra Hospital
ACTIVE_NOT_RECRUITING
Garran
Advara HeartCare
ACTIVE_NOT_RECRUITING
Mulgrave
Advara HeartCare Mulgrave
ACTIVE_NOT_RECRUITING
Mulgrave
Fiona Stanley Hospital Cardiology
NOT_YET_RECRUITING
Murdoch
John Hunter Hospital
RECRUITING
New Lambton Heights
John Hunter Hospital - Cardiovascular Department
ACTIVE_NOT_RECRUITING
New Lambton Heights
Illawarra Heart Health Centre
ACTIVE_NOT_RECRUITING
Wollongong
Bulgaria
MHAT Puls AD, Cardiology Department
COMPLETED
Blagoevgrad
MHAT Haskovo AD
COMPLETED
Haskovo
MHAT Heart and Brain EAD - Pleven, Cardiology
ACTIVE_NOT_RECRUITING
Pleven
UMHAT Sveti Georgi EAD, Plovdiv, Clinic of Cardiology
ACTIVE_NOT_RECRUITING
Plovdiv
MC Hera EOOD - Sofia
ACTIVE_NOT_RECRUITING
Sofia
Medical center ISUL - Tsaritsa Yoanna EOOD
ACTIVE_NOT_RECRUITING
Sofia
Medical Center Synexus Sofia EOOD
COMPLETED
Sofia
UMHAT Sveta Anna Sofia AD, Clinic of Cardiology
COMPLETED
Sofia
UMHATEM N.I. Pirogov EAD
ACTIVE_NOT_RECRUITING
Sofia
Canada
University of Calgary_Calgary
ACTIVE_NOT_RECRUITING
Calgary
Cambridge Cardiac Care Centre
ACTIVE_NOT_RECRUITING
Cambridge
Saul Vizel Pro. Med. Corp
COMPLETED
Cambridge
Institut de Cardiologie de Montreal
ACTIVE_NOT_RECRUITING
Montreal
Montreal General Hospital
ACTIVE_NOT_RECRUITING
Montreal
CHU de Quebec-Uni Laval-Hotel
ACTIVE_NOT_RECRUITING
Québec
Corcare Cardiovascular Research
COMPLETED
Scarborough Village
Diabetes Heart Research Centre
ACTIVE_NOT_RECRUITING
Toronto
Diabetes Heart Research Centre
RECRUITING
Toronto
Clinical Research Solutions Inc.
ACTIVE_NOT_RECRUITING
Waterloo
CPS Research
ACTIVE_NOT_RECRUITING
Waterloo
CPS Research
RECRUITING
Waterloo
France
Centre Hospitalier Regional Universitaire de Tours-Hopital Trousseau
ACTIVE_NOT_RECRUITING
Chambray-lès-tours
Centre Hospitalier Universitaire de Poitiers
COMPLETED
Poitiers
Centre Hospitalier Universitaire de Rennes - Hopital Pontchaillou
COMPLETED
Rennes
Centre Hospitalier Universitaire de Rouen-Hopital Charles Nicolle
COMPLETED
Rouen
Centre Hospitalier Intercommunal Toulon La Seine-Sur-Mer - Hopital Sainte Musse
ACTIVE_NOT_RECRUITING
Toulon
Polyclinique Vauban
COMPLETED
Valenciennes
Chru de Nancy - Hopital Brabois
ACTIVE_NOT_RECRUITING
Vandœuvre-lès-nancy
Germany
Kardiologisch-Angiologische Praxis Herzzentrum Bremen
COMPLETED
Bremen
Uniklinik TU Dresden - Herzzentrum Dresden GmbH
ACTIVE_NOT_RECRUITING
Dresden
Zentrum fuer klinische Studien Suedbrandenburg GmbH
ACTIVE_NOT_RECRUITING
Elsterwerda
Kath. Hospitalvereinigung Thüringen gGmbH - KKH St. Johann Nepomuk - Innere Med. II
COMPLETED
Erfurt
MVZ CCB Frankfurt und Main-Taunus GbR
COMPLETED
Frankfurt
Universitätsklinikum Freiburg - Medical Center
ACTIVE_NOT_RECRUITING
Freiburg Im Breisgau
MVZ im Altstadt-Carree Fulda GmbH - Zentrum für klinische Studien
ACTIVE_NOT_RECRUITING
Fulda
Universität des Saarlandes - Innere Med. III
ACTIVE_NOT_RECRUITING
Homburg
Kardiopraxis Schirmer
COMPLETED
Kaiserslautern
Gesundheitscentrum Mainz (Regner / Schmitt)
COMPLETED
Mainz
Greece
'G. Gennimatas' General Hospital of Athens
NOT_YET_RECRUITING
Athens
'G. Gennimatas' General Hospital of Athens - Cardiology Department
ACTIVE_NOT_RECRUITING
Athens
Alexandra General Hospital, Therapeutic Clinic
ACTIVE_NOT_RECRUITING
Athens
Evangelismos Hospital
ACTIVE_NOT_RECRUITING
Athens
Hygeia General Hospital of Athens
ACTIVE_NOT_RECRUITING
Athens
Konstantopouleio G.H. of Athens, Agia Olga
ACTIVE_NOT_RECRUITING
Athens
Laiko General Hospital of Athens
ACTIVE_NOT_RECRUITING
Athens
Metropolitan General Hospital Healthcare Facilities Operation And Management Single Member S.A. - Cardiology Clinic
ACTIVE_NOT_RECRUITING
Athens
Naval Hospital of Athens
NOT_YET_RECRUITING
Athens
Naval Hospital of Athens - Clinic of Cardiology
ACTIVE_NOT_RECRUITING
Athens
U.G.H of Athens Attikon
NOT_YET_RECRUITING
Chaidari, Athens
U.G.H of Athens Attikon
ACTIVE_NOT_RECRUITING
Chaidari, Athens
General Hospital of Kalamata - Cardiology Department
COMPLETED
Chalcis
General Hospital of Chios Skilitsio - Cardiology Clinic
ACTIVE_NOT_RECRUITING
Chios
Univ Gen Hospital Larisa, Cardiology Medicine Clinic
ACTIVE_NOT_RECRUITING
Larissa
Sismanogleio General Hospital - Cardiology Department
ACTIVE_NOT_RECRUITING
Marousi
'Ippokrateio' General Hospital of Thessaloniki
COMPLETED
Thessaloniki
AHEPA University General Hospital of Thessaloniki
ACTIVE_NOT_RECRUITING
Thessaloniki
Gen Hospital of Thessaloniki G.Papanikolaou,Cardiology Dpt
COMPLETED
Thessaloniki
India
Jawaharlal Nehru Medical College and Hospital
NOT_YET_RECRUITING
Aligarh
Jawaharlal Nehru Medical College and Hospital
ACTIVE_NOT_RECRUITING
Aligarh
KLE's Dr. Prabhakar Kore Hospital & Medical Research Centre
NOT_YET_RECRUITING
Belagavi
KLES Dr. Prabhakar Kore Hospital & Medical Research Centre
COMPLETED
Belagavi
Sri Jayadeva Institute of Cardiovascular Sciences & Research
COMPLETED
Bengaluru
Sri Jayadeva Institute of Cardiovascular Sciences & Research
NOT_YET_RECRUITING
Bengaluru
St John's Medical College Hospital
COMPLETED
Bengaluru
St John's Medical College Hospital
RECRUITING
Bengaluru
All India Institute of Medical Sciences (AIIMS), Bhubaneswar
RECRUITING
Bhubaneswar
All India Institute of Medical Sciences (AIIMS), Bhubaneswar
ACTIVE_NOT_RECRUITING
Bhubaneswar
S.P. Medical College & Associated Group of Hospitals
COMPLETED
Bikaner
Guru Nanak CARE Hospitals
ACTIVE_NOT_RECRUITING
Hyderabad
Malla Reddy Narayana Multispeciality Hospital
ACTIVE_NOT_RECRUITING
Hyderabad
Ganesh Shankar Vidyarthe Memorial (GSVM) Medical College
NOT_YET_RECRUITING
Kanpur
Ganesh Shankar Vidyarthe Memorial (GSVM) Medical College
ACTIVE_NOT_RECRUITING
Kanpur
B M Birla Heart Research Centre
COMPLETED
Kolkata
B M Birla Heart Research Centre
NOT_YET_RECRUITING
Kolkata
Dr. Ram Manohar Lohia Institute of Medical Sciences
COMPLETED
Lucknow
Sanjay Gandhi Postgraduate Institute of Medical Sciences
ACTIVE_NOT_RECRUITING
Lucknow
Manipal Hospital, Mysuru
COMPLETED
Mysuru
All India Institute of Medical Sciences (AIIMS), Nagpur
ACTIVE_NOT_RECRUITING
Nagpur
Sengupta Hospital and Research Institute
RECRUITING
Nagpur
Sengupta Hospital and Research Institute
ACTIVE_NOT_RECRUITING
Nagpur
Chopda Medicare and Research Centre Pvt. Ltd.
NOT_YET_RECRUITING
Nashik
Chopda Medicare and Research Centre Pvt. Ltd.
COMPLETED
Nashik
Vijan Hospital & Research Centre
ACTIVE_NOT_RECRUITING
Nashik
Vijan Hospital & Research Centre
NOT_YET_RECRUITING
Nashik
All India Institute of Medical Sciences (AIIMS)
COMPLETED
New Delhi
G B Pant Institute of Postgraduate Medical Education and Research
ACTIVE_NOT_RECRUITING
New Delhi
G B Pant Institute of Postgraduate Medical Education and Research
NOT_YET_RECRUITING
New Delhi
Rajiv Gandhi Super Speciality Hospital
COMPLETED
New Delhi
Sir Ganga Ram Hospital
ACTIVE_NOT_RECRUITING
New Delhi
Vardhaman Mahavir Medical College & Safdarjung Hospital
COMPLETED
New Delhi
Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER)
COMPLETED
Puducherry
Villoo Poonawalla Memorial Hospital
ACTIVE_NOT_RECRUITING
Pune
Kasturba Medical College and Hospital, Manipal
NOT_YET_RECRUITING
Udupi
Kasturba Medical College and Hospital, Manipal
COMPLETED
Udupi
Rhythm Heart Institute
ACTIVE_NOT_RECRUITING
Vadodara
Government Siddhartha Medical College & Government General Hospital, Vijayawada
ACTIVE_NOT_RECRUITING
Vijayawada
King George Hospital
COMPLETED
Visakhapatnam
Malaysia
Hospital Sultanah Bahiyah
ACTIVE_NOT_RECRUITING
Alor Star
Hospital Raja Permaisuri Bainun Ipoh
COMPLETED
Ipoh
Hospital Sultanah Aminah
RECRUITING
Johor Bahru
Hospital Sultanah Aminah
ACTIVE_NOT_RECRUITING
Johor Bahru
Hospital Serdang
ACTIVE_NOT_RECRUITING
Kajang
Hospital Raja Perempuan Zainab II
ACTIVE_NOT_RECRUITING
Kota Bharu
Hospital Raja Perempuan Zainab II
RECRUITING
Kota Bharu, Kelantan
University Malaya Medical Centre
RECRUITING
Kuala Lumpur
Hospital Tengku Ampuan Afzan
ACTIVE_NOT_RECRUITING
Kuantan
University Malaya Medical Centre
ACTIVE_NOT_RECRUITING
Lembah Pantai
Poland
Uniwersytecki Szpital Kliniczny w Bialymstoku
NOT_YET_RECRUITING
Bialystok
Uniwersytecki Szpital Kliniczny w Bialymstoku
COMPLETED
Bialystok
American Heart of Poland S.A.
ACTIVE_NOT_RECRUITING
Bielsko-biala
10 Wojskowy Szpital Kliniczny z Poliklinika - Samodzielny Publiczny Zaklad Opieki Zdrowotnej w Bydgoszczy
COMPLETED
Bydgoszcz
Centrum Medyczne Intercor Sp. z o.o.
ACTIVE_NOT_RECRUITING
Bydgoszcz
Ind. Prak. Lek. w dziedz. Kardiologii lek. med. K. Cymerman
ACTIVE_NOT_RECRUITING
Gdynia
Szpitale Pomorskie Sp. z o.o.
NOT_YET_RECRUITING
Gdynia
Szpitale Pomorskie Sp. z o.o.
COMPLETED
Gdynia
Pratia S.A.
COMPLETED
Jelenia Góra
Cardiomedicum Sp. z o.o.
NOT_YET_RECRUITING
Krakow
Cardiomedicum Sp. z o.o.
ACTIVE_NOT_RECRUITING
Krakow
Linden sp. z o.o. sp. k.
COMPLETED
Krakow
Uniwersytecki Szpital Kliniczny nr 2 Uniwersytetu Medycznego w Lodzi
ACTIVE_NOT_RECRUITING
Lodz
Wojewodzkie Wielospecjalistyczne Centrum Onkologii i Traumatologii im. M. Kopernika
ACTIVE_NOT_RECRUITING
Lodz
Zanamed Medical Clinic Sp. z o.o.
COMPLETED
Lublin
Formed 2 Sp. z o.o.
ACTIVE_NOT_RECRUITING
Oświęcim
Trialmed Sp. z o. o.
RECRUITING
Piotrkow Trybunalski
Trialmed Sp. z o. o.
ACTIVE_NOT_RECRUITING
Piotrkow Trybunalski
Uniwersytecki Szpital Kliniczny W Poznaniu
COMPLETED
Poznan
Uniwersytecki Szpital Kliniczny W Poznaniu
NOT_YET_RECRUITING
Poznan
Samodzielny Publiczny Zaklad Opieki Zdrowotnej W Pulawach
ACTIVE_NOT_RECRUITING
Puławy
American Heart of Poland S.A.
COMPLETED
Tychy
Panstwowy Instytut Medyczny Ministerstwa Spraw Wewnetrznych I Administracji
COMPLETED
Warsaw
Kardio Life
NOT_YET_RECRUITING
Włocławek
Kardio Life - Tomasz Borkowski
ACTIVE_NOT_RECRUITING
Włocławek
4 Wojskowy Szpital Kliniczny Z Poliklinika Samodzielny Publiczny Zaklad Opieki Zdrowotnej We Wroclawiu
ACTIVE_NOT_RECRUITING
Wroclaw
Prywatna Praktyka Lekarska Anna Chudoba
ACTIVE_NOT_RECRUITING
Żyrardów
Portugal
CHTâmega e Sousa - Hospital Padre Américo
NOT_YET_RECRUITING
Guilhufe - Penafiel
Centro Hospitalar Lisboa Norte
NOT_YET_RECRUITING
Lisbon
CHLO, EPE - Hospital São Francisco Xavier
NOT_YET_RECRUITING
Lisbon
Hospital da Luz
NOT_YET_RECRUITING
Lisbon
Centro Hospitalar de Setubal
NOT_YET_RECRUITING
Setúbal
Spain
Hospital Vithas Sevilla
ACTIVE_NOT_RECRUITING
Castilleja De La Cuesta
Hospital Gregorio Marañón
ACTIVE_NOT_RECRUITING
Madrid
Hospital Ramón y Cajal
ACTIVE_NOT_RECRUITING
Madrid
Hospital Universitario Puerta de Hierro Majadahonda
ACTIVE_NOT_RECRUITING
Majadahonda
Hospital Universitario de Salamanca
COMPLETED
Salamanca
Hospital Universitario de Salamanca
NOT_YET_RECRUITING
Salamanca
H Virgen del Camino_Sanlúcar_Medicina Interna
ACTIVE_NOT_RECRUITING
Sanlúcar De Barrameda
Complejo Hospitalario Universitario de Santiago
ACTIVE_NOT_RECRUITING
Santiago De Compostela
Clínica Nuevas Tecnologías en Diabetes y Endocrinología
COMPLETED
Seville
Fundación para la Investigación del Hospital Clínico de Valencia (INCLIVA)
ACTIVE_NOT_RECRUITING
Valencia
Turkey
Adana Şehir Eğitim ve Araştırma Hastanesi
ACTIVE_NOT_RECRUITING
Adana
T.C. Saglık Bakanlıgı Adana Sehir Egitim ve Arastirma Hastan
NOT_YET_RECRUITING
Adana
Afyonkarahisar Health Sciences University
NOT_YET_RECRUITING
Afyonkarahisar
Afyonkarahisar Sağlık Bilimleri Üniversitesi Sağlık Uygulama Ve Araştırma Merkezi- Kardiyoloji
ACTIVE_NOT_RECRUITING
Afyonkarahisar
Ankara Bilkent Şehir Hastanesi-Kardiyoloji
ACTIVE_NOT_RECRUITING
Ankara
Ankara Sehir Hastanesi Cardiology
NOT_YET_RECRUITING
Ankara
Bursa Şehir Hastanesi- Kardiyoloji
ACTIVE_NOT_RECRUITING
Bursa
Trakya Üniversitesi Tıp Fakültesi Hastanesi- Kardiyoloji
ACTIVE_NOT_RECRUITING
Edirne
Trakya University
NOT_YET_RECRUITING
Edirne
Eskişehir Osmangazi Üniversitesi Hastanesi- Kardiyoloji
ACTIVE_NOT_RECRUITING
Eskişehir
Başakşehir Çam ve Sakura Şehir Hastanesi
ACTIVE_NOT_RECRUITING
Istanbul
Erciyes Üniversitesi Hastanesi- Kardiyoloji
RECRUITING
Kayseri
Erciyes University Cardiology
NOT_YET_RECRUITING
Kayseri
Kocaeli Üniversitesi Hastanesi- Kardiyoloji
ACTIVE_NOT_RECRUITING
Kocaeli
United Kingdom
FutureMeds
ACTIVE_NOT_RECRUITING
Birmingham
St. Richard's Hospital_Cardiology
ACTIVE_NOT_RECRUITING
Chichester
Ninewells Hospital
COMPLETED
Dundee
Raigmore Hospital
COMPLETED
Inverness
Peterborough City Hospital
COMPLETED
Peterborough
Contact Information
Primary
Novo Nordisk
clinicaltrials@novonordisk.com
(+1) 866-867-7178
Time Frame
Start Date: 2024-04-01
Estimated Completion Date: 2027-01-08
Participants
Target number of participants: 680
Treatments
Active_comparator: Ziltivekimab
Participants will receive ziltivekimab administered subcutaneously (s.c.) once-monthly and added to standard of care for 12 months.
Placebo_comparator: Placebo
Participants will receive placebo matched to ziltivekimab administered s.c. once-monthly and added to standard of care for 12 months.
Related Therapeutic Areas
Sponsors
Leads: Novo Nordisk A/S