Comparision of Allogeneic Hematopoietic Stem Cell Transplantation between Children with Thalassemia of Different Ages.

Journal: Zhongguo Shi Yan Xue Ye Xue Za Zhi
Treatment Used: Allogeneic Hematopoietic Stem Cell Transplantation
Number of Patients: 0
Published:
MediFind Summary

Summary: This study investigated the difference of therapeutic effects of allogeneic hematopoietic stem cell transplantation (uses healthy blood stem cells from a donor to replace diseased or damaged bone marrow) in children with thalassemia (inherited blood disorder that reduces the production of hemoglobin, the protein in red blood cells that carries oxygen) of different ages.

Conclusion: Children in the low age (2-5 years old) group showed fewer complications and higher quality of life after transplantation, therefore, stem cell transplantation (uses healthy blood stem cells from a donor to replace diseased or damaged bone marrow) at 2-5 years old was more conducive to rehabilitation of children with thalassemia (inherited blood disorder that reduces the production of hemoglobin, the protein in red blood cells that carries oxygen).

Abstract

Objective: To investigate the difference of therapeutic effects on children with thalassemia at different age after hematopoietic stem cell transplantation.

Methods: The clinical data of children with thalassemia treated in our hospital were retrospectively analyzed. The children were divided into 2-5 years old group and 6-12 years old group. The success rate of implantation, transplant-related mortality, GVHD incidence, and other transplant-related complications, as well as thalassemia-free survival (TFS) were compared between the two groups.

Results: The incidence of GVHD, hemorrhagic cystitis and severe oral mucositis after transplantation in the 2-5 years old group were significantly lower than those in the 6-12 years old group, while there was no statistically significant difference in the TFS between the two groups.

Conclusions: Children in the low age (2-5 years old) group show fewer complications and higher quality of life after transplantation, therefore, stem cell transplantation at 2-5 years old is more conducive to rehabilitation of the children with thalassemia.

Authors
Dong-liang Kang, Yong-hong Tan, Ya-mei Chen, Jing-yuan Lu, Jie Shi, Xiu-zhen Yan, Quan-yi Lu

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