What is the definition of Hyperaldosteronism?

Hyperaldosteronism is a disorder in which the adrenal gland releases too much of the hormone aldosterone into the blood.

Hyperaldosteronism can be primary or secondary.

What are the alternative names for Hyperaldosteronism?

Conn syndrome; Mineralocorticoid excess

What are the causes for Hyperaldosteronism?

Primary hyperaldosteronism is due to a problem of the adrenal glands themselves, which causes them to release too much aldosterone.

In contrast, with secondary hyperaldosteronism, a problem elsewhere in the body causes the adrenal glands to release too much aldosterone. These problems can be with genes, diet, or a medical disorder such as with the heart, liver, kidneys, or high blood pressure.

Most cases of primary hyperaldosteronism are caused by a noncancerous (benign) tumor of the adrenal gland. The condition mostly affects people 30 to 50 years old and is a common cause of high blood pressure in middle age.

What are the symptoms for Hyperaldosteronism?

Primary and secondary hyperaldosteronism have common symptoms, including:

  • High blood pressure
  • Low level of potassium in the blood
  • Feeling tired all the time
  • Headache
  • Muscle weakness
  • Numbness

What are the current treatments for Hyperaldosteronism?

Primary hyperaldosteronism caused by an adrenal gland tumor is usually treated with surgery. It can sometimes be treated with medicines. Removing the adrenal tumor may control the symptoms. Even after surgery, some people still have high blood pressure and need to take medicine. But often, the number of medicines or doses can be lowered.

Limiting salt intake and taking medicine may control the symptoms without surgery. Medicines to treat hyperaldosteronism include:

  • Drugs that block the action of aldosterone
  • Diuretics (water pills), which help manage fluid buildup in the body

Secondary hyperaldosteronism is treated with medicines (as described above) and limiting salt intake. Surgery is usually not used.

What is the outlook (prognosis) for Hyperaldosteronism?

The outlook for primary hyperaldosteronism is good with early diagnosis and treatment.

The outlook for secondary hyperaldosteronism depends on the cause of the condition.

What are the possible complications for Hyperaldosteronism?

Primary hyperaldosteronism can cause very high blood pressure, which can damage many organs, including the eyes, kidneys, heart and brain.

Erection problems and gynecomastia (enlarged breasts in men) may occur with long-term use of medicines to block the effect of hyperaldosteronism. 

When should I contact a medical professional for Hyperaldosteronism?

Call for an appointment with your provider if you develop symptoms of hyperaldosteronism.

Endocrine glands
Adrenal gland hormone secretion


Carey RM, Padia SH. Primary mineralocorticoid excess disorders and hypertension. In: Jameson JL, De Groot LJ, de Kretser DM, et al, eds. Endocrinology: Adult and Pediatric. 7th ed. Philadelphia, PA: Elsevier Saunders; 2016:chap 108.

Nieman LK. Adrenal cortex. In: Goldman L, Schafer AI, eds. Goldman-Cecil Medicine. 26th ed. Philadelphia, PA: Elsevier; 2020:chap 214.

  • Condition: Recurrence of Primary Aldosteronism (PA) 10 Years After Left Adrenalectomy for Aldosterone-Producing Adenoma (APA)
  • Journal: Frontiers in endocrinology
  • Treatment Used: Partial Adrenalectomy
  • Number of Patients: 1
  • Published —
This case report describes a 29-year-old female patient diagnosed with a recurrence of primary aldosteronism 10 years after left adrenalectomy for an aldosterone-producing adenoma.
  • Condition: Gitelman's and Bartter's Syndromes (BS)
  • Journal: Nutrients
  • Treatment Used: Dietary Treatments
  • Number of Patients: 0
  • Published —
This article discusses dietary strategies for the treatment of patients with Gitelman's (GS) and Bartter's (BS) syndromes (kidney disorders).