The Predictive Value of the Heart Rate Response to Breathing Maneuvers for Inducible Myocardial Perfusion Deficits

Status: Recruiting
Location: See location...
Intervention Type: Other
Study Type: Observational
SUMMARY

Breathing maneuvers, i.e. hyperventilation followed by breath-holding, have been shown to change coronary dynamics; hyperventilating narrows the coronary arteries, puts stress on the heart, and increases the heart rate, whereas breath-hold dilates the coronary arteries and decreases the heart rate, rest. Heart rate response to hyperventilation has been reported to have high diagnostic accuracy to rule out heart disease. The cardiac stress test, the modality of choice for the initial assessment of patients with suspected coronary artery disease(CAD), is routinely overprescribed by physicians, which exerts a financial burden on the healthcare system. Hence, developing an inexpensive, reliable, and available tool-HR response to breathing maneuvers- may avoid unnecessary referrals for cardiac stress tests by an effective differentiation of patients with CAD from healthy people. This study aims to assess the negative predictive value of the HR response to a 4-minute breathing maneuver for inducible myocardial ischemia, avoiding further stress testing as a gatekeeper.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 35
Healthy Volunteers: Accepts Healthy Volunteers
View:

• Healthy volunteers:

• Aged > 35

• No known current or pre-existing problems that would affect the cardiovascular or respiratory system

• Patient population:

• Aged > 35

• Clinically indicated referral for adenosine stress first-pass perfusion MRI in subjects with known or suspected coronary artery disease

Locations
Other Locations
Canada
The Research Institute of the McGill University Health Center
Recruiting
Montréal
Time Frame
Start Date: July 14, 2020
Estimated Completion Date: September 30, 2022
Participants
Target number of participants: 86
Treatments
Healthy volunteers
Aged more than 35~No known current or pre-existing problems that would affect the cardiovascular or respiratory system
Patient population
Aged more than 35~Referral of subjects with known or suspected CAD for adenosine stress first-pass perfusion MRI based on the clinical judgement of their referring physician
Sponsors
Leads: McGill University Health Centre/Research Institute of the McGill University Health Centre

This content was sourced from clinicaltrials.gov

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