Vocal Cord Responses During Hyperventilation in Normal Individuals and in Mild and Severe

Status: Recruiting
Location: See location...
Intervention Type: Drug, Other
Study Type: Observational
SUMMARY

The Investigators aim to: Study the effect of hyperventilation on the development of paradoxical vocal cord movement (PVCM) in healthy individuals and in patients with mild and severe asthma, Relate PVCM to airway symptoms and measurements of intra- and extra-thoracic airway hyperresponsiveness (ET-AHR), Evaluate the effects of inhaled anti-cholinergic agents on PVCM induced by hyperventilation. Hypotheses: In health PVCM will not occur in response to hyperventilation, In asthma PVCM will occur in response to hyperventilation, Airway symptoms and ET-AHR will develop in parallel with PVCM, Inhaled anticholinergic agents will prevent PVCM induced by hyperventilation.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Maximum Age: 65
Healthy Volunteers: Accepts Healthy Volunteers
View:

• age >18 to 65 years old

• non-smokers

• No history of chronic respiratory symptoms.

• The Investigators shall recruit a total of 16 patients with asthma - 8 patients with mild asthma (Group 2) and 8 patients with severe asthma (Group 3).

• Mild asthma will be defined as patients with forced expiratory volume in 1 second (FEV1) >80% predicted.

• Severe asthma will be defined as patients with FEV1 50-60% predicted.

• Asthmatics will also have a forced expiratory ratio (FER) less than the lower limit of normal, indicating obstruction.

• age 18-65 years

• A history of asthma defined as a bronchodilator response with increase in FEV1 >12% and 200mls or positive bronchoprovocation testing (methacholine).

• Asthmatics will have FEV1 >50% predicted.

Locations
Other Locations
Australia
Monash Medical Centre
Recruiting
Clayton
Contact Information
Primary
Laurence Ruane, BSc
laurence.ruane@monashhealth.org
+61 (03) 9594 2811
Time Frame
Start Date: June 1, 2018
Estimated Completion Date: December 2024
Participants
Target number of participants: 24
Treatments
Healthy Control
Acute Hyperventilation and effects on vocal cord movement.~Chronic Hyperventilation and effects on vocal cord movement.~Effects of anticholinergic medication on paradoxical vocal cord movement.
Mild Asthmatics
Acute Hyperventilation and effects on vocal cord movement.~Chronic Hyperventilation and effects on vocal cord movement.~Effects of anticholinergic medication on paradoxical vocal cord movement.
Severe Asthmatics
Acute Hyperventilation and effects on vocal cord movement.~Chronic Hyperventilation and effects on vocal cord movement.~Effects of anticholinergic medication on paradoxical vocal cord movement.
Related Therapeutic Areas
Sponsors
Leads: Monash Medical Centre

This content was sourced from clinicaltrials.gov

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