Learn About Incontinentia Pigmenti

What is the definition of Incontinentia Pigmenti?

Incontinentia pigmenti is a condition that can affect many body systems, particularly the skin. This condition occurs much more often in females than in males.

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What are the causes of Incontinentia Pigmenti?

Mutations in the IKBKG gene cause incontinentia pigmenti. The IKBKG gene provides instructions for making a protein that helps regulate nuclear factor-kappa-B. Nuclear factor-kappa-B is a group of related proteins that helps protect cells from self-destructing (undergoing apoptosis) in response to certain signals.

How prevalent is Incontinentia Pigmenti?

Incontinentia pigmenti is an uncommon disorder. Between 900 and 1,200 affected individuals have been reported in the scientific literature. Most of these individuals are female, but several dozen males with incontinentia pigmenti have also been identified.

Is Incontinentia Pigmenti an inherited disorder?

This condition is inherited in an X-linked dominant pattern. The gene associated with this condition is located on the X chromosome, which is one of the two sex chromosomes. In females (who have two X chromosomes), a mutation in one of the two copies of the gene in each cell is sufficient to cause the disorder. Some cells produce a normal amount of IKBKG protein and other cells produce none. The resulting imbalance in cells producing this protein leads to the signs and symptoms of incontinentia pigmenti.

Who are the top Incontinentia Pigmenti Local Doctors?
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Highly rated in
4
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Institute Of Genetics And Biophysics

Naples, IT 80131

Francesca Fusco is in Naples, Italy. Fusco is rated as an Elite expert by MediFind in the treatment of Incontinentia Pigmenti. She is also highly rated in 4 other conditions, according to our data. Her top areas of expertise are Incontinentia Pigmenti, Clouston Syndrome, Ectodermal Dysplasias, and Aplasia Cutis Congenita.

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Highly rated in
34
conditions

Nagoya University Graduate School Of Medicine

Nagoya, JP 

Michihiro Kono is in Nagoya, Japan. Kono is rated as an Elite expert by MediFind in the treatment of Incontinentia Pigmenti. They are also highly rated in 34 other conditions, according to our data. Their top areas of expertise are Dyschromatosis Symmetrica Hereditaria, Pigmented Purpuric Dermatosis, Incontinentia Pigmenti, and Benign Chronic Pemphigus.

 
 
 
 
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Elite
Highly rated in
66
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Hôpital Necker Enfants Malades

Paris, FR 75015

Christine Bodemer is in Paris, France. Bodemer is rated as an Elite expert by MediFind in the treatment of Incontinentia Pigmenti. She is also highly rated in 66 other conditions, according to our data. Her top areas of expertise are Incontinentia Pigmenti, Netherton Syndrome, Congenital Generalized Fibromatosis, and Exfoliative Dermatitis.

What are the latest Incontinentia Pigmenti Clinical Trials?
The Effect of Topical Anesthetic Using Lidocaine 2.5%/Prilocaine 2.5% Versus Lidocaine 7%/Tetracaine 7% Cream on Patients' Pain and Operative Experience During Treatment With QSwitched 532nm Laser
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Evaluating the Efficacy of the Melanocyte Keratinocyte Transplantation Procedure in the Treatment of Vitiligo
Who are the sources who wrote this article ?

Published Date:updated Last, June

Published By: National Institutes of Health

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