Predictors for Nasal Intermittent Positive Pressure Ventilation Failure for Premature Infants With Respiratory Distress Syndrome

Status: Recruiting
Location: See location...
Intervention Type: Other
Study Type: Observational
SUMMARY

Non-invasive respiratory support methods have been widely used in premature babies with respiratory distress syndrome (RDS) which has changed the basic management of premature babies in the early period. According to the 2019 European Guidelines on RDS management, early nasal CPAP is recommended as first-line therapy in infants <30 weeks of age who are at risk of RDS who do not require mechanical ventilation (MV). However, some of the premature babies have faced non-invasive ventilation failure. Remarkably, infants who experience non-invasive ventilation failure are at increased risk of death, pneumothorax, intraventricular hemorrhage, and bronchopulmonary dysplasia (BPD), among other morbidities. In non-invasive ventilation failure, although demographic factors such as small gestational age, low birth weight, and male gender play a role, it has been suggested that surfactant deficiency may also play an important role. The most frequently reported risk factor in predicting non-invasive failure in studies is the fraction of inspiring oxygen during the first hours of life. In addition, positive end-expiratory airway pressure (PEEP) required for patient stabilization was found to be a potential predictor. However, there are still limited data to predict non-invasive ventilation failure. Which newborns are at high risk for non-invasive ventilation failure? and When should the surfactant be applied?. The study is a single-center, prospective study to evaluate prognostic factors, and most importantly to define the FiO2 threshold, which is an indicator of possible non-invasive ventilation failure in infants supported with nasal intermittent positive pressure ventilation.

Eligibility
Participation Requirements
Sex: All
View:

• <32 weeks preterm babies

• Those who have received nasal intermittent positive pressure ventilation

Locations
Other Locations
Turkey
Ankara City Hospital Bilkent
Recruiting
Ankara
Contact Information
Primary
Mustafa Senol Akin
mustafasenolakin@gmail.com
+905558760585
Backup
Fatma Nur Sari
fatmanurselek@gmail.com
Time Frame
Start Date: December 1, 2020
Estimated Completion Date: February 1, 2023
Participants
Target number of participants: 400
Treatments
non-invasive ventilation failure
babies who will be intubated in the first 72 hours
non-invasive ventilation success
babies who will not intubated in the first 72 hours
Sponsors
Leads: Ankara City Hospital Bilkent

This content was sourced from clinicaltrials.gov