Open vs Arthroscopic Treatment of Septic Arthritis in the Adult Native Knee: A Prospective Trial

Trial Information
Status: Recruiting
Location: See location...
Intervention Type: Procedure
Study Type: Interventional
Study Phase: Not Applicable

Surgical excisional debridement is the mainstay of management in septic arthritis with necessary decompression, lavage, debridement, and partial synovectomy. However, there has been considerable debate over the optimal modality. Most surgeons perform an open arthrotomy or arthroscopic debridement, although serial aspiration can be considered as an option in very limited circumstances with patients who cannot tolerate surgery. While open arthrotomy has been often utilized, there has been an increasing number of proponents for arthroscopic treatment citing lower re-infection rates and better functional outcomes. However, there has been a lack of well-designed prospective studies comparing surgical treatment modalities for native knee septic arthritis. The goals of this present study are to determine if arthroscopic management of septic arthritis in the native knee resulted in a lower number of surgeries and a shorter length of stay compared to open arthrotomy. Secondary outcomes included differences in postoperative pain and improvements in Lysholm knee scores.

Am I eligible for this trial?
Participation Requirements
Healthy Volunteers:

• Adults (>18 years old)

• Have a diagnosis of septic arthritis of the native knee (synovial WBC >50k or acrystalline elevated synovial WBC >25,000 with high clinical suspicion)

• Willingness to participate in the study

Where is this trial taking place?
United States
University Medical Center of El Paso
El Paso
Who do I contact about this trial?
Matthew E Wells, DO
When is this trial taking place?
Start Date: April 1, 2021
Estimated Completion Date: June 30, 2024
How many participants will be in this trial?
Target number of participants: 50
What treatment is being studied in this trial?
Experimental: Patients with confirmed septic arthritis of the native knee

This content was sourced from

Failure of a Single Surgical Debridement in Septic Arthritis of the Native Hip: a Retrospective Study
Status:Active, not recruiting
Start Date:January 26, 2021
Study Type:Diagnostic Test
Alpha-Defensin and Synovial Proteins to Improve Detection of Pediatric Septic Arthritis
Start Date:June 28, 2016
Study Type:Diagnostic Test
Phase: Not Applicable