Efficacy of Corticosteroids in Reducing Renal Scarring in Acute Pyelonephritis in Children:A Multi-centre, Double-blind, Randomized, Placebo-controlled, Clinical Trial

Trial Information
Who is this study for? Patients with Kidney Scarring, Acute Pyelonephritis, Urinary Tract Infections, Chronic Renal Failure
What treatments are being studied? Dexamethasone Oral
Status: Recruiting
Location: See location...
Intervention Type: Drug
Study Type: Interventional
Study Phase: Phase 3

Urinary tract infection (UTI) is the most frequently occurring serious bacterial infection in young children and accounts 5 to 14% of emergency department visits Formation of renal scarring in children has been associated with serious complications as hypertension, preeclampsia, and end stage renal failure in young age . So, this study aims to determine whether dexamethasone reduces the renal scarring in children will be treated with antibiotics for acute pyelonephritis. investigators propose to conduct a multi center, randomized, placebo-controlled, double-blind clinical trial, that will evaluate the efficacy of dexamethasone (0.3 mg/kg every 12 hours per day orally for 3 days) in preventing renal scarring in young febrile children (2 months to 14 years) with a first-diagnosed UTI. 120 Participants will be enrolled over a 3-year period from 6 sites.

Am I eligible for this trial?
Participation Requirements
Minimum Age:
2 months
Maximum Age:
Healthy Volunteers:
Accepts Healthy Volunteers

• First episode of acute febrile UTI.

• From 2 months to 14 years of age.

• Fever: ≥ 38.3°C, measured at home or at Pediatric Emergency centers.,

Where is this trial taking place?
Other Locations
Hamad Medical Corporation
Who do I contact about this trial?
Mahmoud Alhandi Omar Helal
Mohammad Alamri
When is this trial taking place?
Start Date: March 3, 2021
Estimated Completion Date: December 2024
How many participants will be in this trial?
Target number of participants: 120
What treatment is being studied in this trial?
Active Comparator: Adjuvant dexamethasone
Drug: Dexamethasone
Placebo Comparator: Placebo
Drug: Placebo
Who are the authors of this trial?
Mohammad Alamri, Mahmoud Alhandi Omar Helal

This content was sourced from clinicaltrials.gov