Learn About Intrahepatic Cholestasis of Pregnancy

What is the definition of Intrahepatic Cholestasis of Pregnancy?

Intrahepatic cholestasis of pregnancy is a liver disorder that occurs in pregnant women. Cholestasis is a condition that impairs the release of a digestive fluid called bile from liver cells. As a result, bile builds up in the liver, impairing liver function. Because the problems with bile release occur within the liver (intrahepatic), the condition is described as intrahepatic cholestasis. Intrahepatic cholestasis of pregnancy usually becomes apparent in the third trimester of pregnancy. Bile flow returns to normal after delivery of the baby, and the signs and symptoms of the condition disappear. However, they can return during later pregnancies.

Save information for later
Sign Up
What are the causes of Intrahepatic Cholestasis of Pregnancy?

Genetic changes in the ABCB11 or the ABCB4 gene can increase a woman's likelihood of developing intrahepatic cholestasis of pregnancy.

How prevalent is Intrahepatic Cholestasis of Pregnancy?

Intrahepatic cholestasis of pregnancy is estimated to affect 1 percent of women of Northern European ancestry. The condition is more common in certain populations, such as women of Araucanian Indian ancestry in Chile or women of Scandinavian ancestry. This condition is found less frequently in other populations.

Is Intrahepatic Cholestasis of Pregnancy an inherited disorder?

Susceptibility to intrahepatic cholestasis of pregnancy is inherited in an autosomal dominant pattern, which means one copy of the altered gene in each cell is sufficient to increase the risk of developing the disorder. Some women with an altered gene do not develop intrahepatic cholestasis of pregnancy. Many other factors likely contribute to the risk of developing this complex disorder.

Who are the top Intrahepatic Cholestasis of Pregnancy Local Doctors?
Elite
Highly rated in
9
conditions

King's College London

London, ENG, GB 

Catherine Williamson is in London, United Kingdom. Williamson is rated as an Elite expert by MediFind in the treatment of Intrahepatic Cholestasis of Pregnancy. She is also highly rated in 9 other conditions, according to our data. Her top areas of expertise are Intrahepatic Cholestasis of Pregnancy, Cholestasis, Bile Duct Obstruction, and Hyperemesis Gravidarum.

Elite
Highly rated in
3
conditions

King's College London

London, ENG, GB 

Caroline Ovadia is in London, United Kingdom. Ovadia is rated as an Elite expert by MediFind in the treatment of Intrahepatic Cholestasis of Pregnancy. She is also highly rated in 3 other conditions, according to our data. Her top areas of expertise are Intrahepatic Cholestasis of Pregnancy, Cholestasis, Bile Duct Obstruction, and Gestational Diabetes.

 
 
 
 
Learn about our expert tiers
Learn more
Elite
Highly rated in
3
conditions

King's College London

London, ENG, GB 

Georgia Papacleovoulou is in London, United Kingdom. Papacleovoulou is rated as an Elite expert by MediFind in the treatment of Intrahepatic Cholestasis of Pregnancy. She is also highly rated in 3 other conditions, according to our data. Her top areas of expertise are Intrahepatic Cholestasis of Pregnancy, Cholestasis, Bile Duct Obstruction, and Macrosomia.

What are the latest Intrahepatic Cholestasis of Pregnancy Clinical Trials?
Inflammation in Intrahepatic Cholestasis of Pregnancy
Match to trials
Find the right clinical trials for you in under a minute
Get started
A Longitudinal Study of Alterations in Metabolic Markers and Gut Hormones in Pregnant and Non-pregnant Patients With Intrahepatic Cholestasis of Pregnancy, Gestational Diabetes Mellitus and Normal Pregnant and Non-pregnant Controls
Who are the sources who wrote this article ?

Published Date: May 01, 2015Published By: National Institutes of Health

What are the Latest Advances for Intrahepatic Cholestasis of Pregnancy?
Effect of Levothyroxine on Pregnancy Outcomes in Pregnant Women With Hypothyroxinemia: An Interventional Study.
Intrahepatic cholestasis of pregnancy resistant to both therapeutic plasma exchange and albumin dialysis.
Tired of the same old research?
Check Latest Advances
A Case of Acute Aortic Dissection Following Intrapartum in a Patient with Marfan ' s Syndrome.