Learn About Kindler Syndrome

What is the definition of Kindler Syndrome?

Kindler syndrome is a rare type of epidermolysis bullosa, which is a group of genetic conditions that cause the skin to be very fragile and to blister easily.

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What are the causes of Kindler Syndrome?

Kindler syndrome results from mutations in the FERMT1 gene. This gene provides instructions for making a protein known as kindlin-1. This protein is found in epithelial cells, which are the cells that line the surfaces and cavities of the body. In the skin, kindlin-1 plays a critical role in specialized cells called keratinocytes, which are the major component of the epidermis. Kindlin-1 is involved in several important cell functions, including cell growth and division (proliferation), the attachment of cells to the underlying network of proteins and other molecules (cell-matrix adhesion), and the movement (migration) of cells.

How prevalent is Kindler Syndrome?

Kindler syndrome appears to be rare. About 250 cases have been reported worldwide.

Is Kindler Syndrome an inherited disorder?

This condition is inherited in an autosomal recessive pattern, which means both copies of the gene in each cell have mutations. The parents of an individual with an autosomal recessive condition each carry one copy of the mutated gene, but they typically do not show signs and symptoms of the condition.

Who are the top Kindler Syndrome Local Doctors?
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36
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University Of Freiburg

Freiburg, BW, DE 

Cristina Has is in Freiburg, Germany. Has is rated as an Elite expert by MediFind in the treatment of Kindler Syndrome. She is also highly rated in 36 other conditions, according to our data. Her top areas of expertise are PARC Syndrome, Epidermolysis Bullosa, Bullae, and Kindler Syndrome.

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Highly rated in
13
conditions

King's College London

Camberley, ENG, GB 

Joey Cheong-Lai is in Camberley, United Kingdom. Cheong-Lai is rated as an Elite expert by MediFind in the treatment of Kindler Syndrome. They are also highly rated in 13 other conditions, according to our data. Their top areas of expertise are Kindler Syndrome, PARC Syndrome, Bullae, and Epidermolysis Bullosa.

 
 
 
 
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Elite
Highly rated in
24
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German Dermatological Society

Freiburg, DE 

Leena Tuderman-Bruckner is in Freiburg, Germany. Tuderman-Bruckner is rated as an Elite expert by MediFind in the treatment of Kindler Syndrome. She is also highly rated in 24 other conditions, according to our data. Her top areas of expertise are Epidermolysis Bullosa, Kindler Syndrome, Bullae, and Dystrophic Epidermolysis Bullosa.

What are the latest Kindler Syndrome Clinical Trials?
The State of Sexual Development in Children With Inherited Epidermolysis Bullosa
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Who are the sources who wrote this article ?

Published Date: June 01, 2016Published By: National Institutes of Health

What are the Latest Advances for Kindler Syndrome?

There is no recent research available for this condition. Please check back because thousands of new papers are published every week and we strive to find and display the most recent relevant research as soon as it is available.