Learn About Lactate Dehydrogenase Deficiency

What is the definition of Lactate Dehydrogenase Deficiency?

Lactate dehydrogenase deficiency is a condition that affects how the body breaks down sugar to use as energy in cells, primarily muscle cells.

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What are the causes of Lactate Dehydrogenase Deficiency?

Mutations in the LDHA gene cause lactate dehydrogenase-A deficiency, and mutations in the LDHB gene cause lactate dehydrogenase-B deficiency. These genes provide instructions for making the lactate dehydrogenase-A and lactate dehydrogenase-B pieces (subunits) of the lactate dehydrogenase enzyme. This enzyme is found throughout the body and is important for creating energy for cells. There are five different forms of this enzyme, each made up of four protein subunits. Various combinations of the lactate dehydrogenase-A and lactate dehydrogenase-B subunits make up the different forms of the enzyme.

How prevalent is Lactate Dehydrogenase Deficiency?

Lactate dehydrogenase deficiency is a rare disorder. In Japan, this condition affects 1 in 1 million individuals; the prevalence of lactate dehydrogenase deficiency in other countries is unknown.

Is Lactate Dehydrogenase Deficiency an inherited disorder?

This condition is inherited in an autosomal recessive pattern, which means both copies of the gene in each cell have mutations. The parents of an individual with an autosomal recessive condition each carry one copy of the mutated gene, but they typically do not show signs and symptoms of the condition.

Who are the top Lactate Dehydrogenase Deficiency Local Doctors?
Distinguished
Highly rated in
8
conditions

Democritus University Of Thrace

Alexandroupoli, ESYE11, GR 68100

Alexandra Giatromanolaki is in Alexandroupoli, Greece. Giatromanolaki is rated as a Distinguished expert by MediFind in the treatment of Lactate Dehydrogenase Deficiency. She is also highly rated in 8 other conditions, according to our data. Her top areas of expertise are Lactate Dehydrogenase Deficiency, Cerebral Hypoxia, Lung Cancer, and Non-Small Cell Lung Cancer NCSLC.

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Highly rated in
1
conditions

Higashi Ku

Saitama, JP 33885

Masato Maekawa is in Saitama, Japan. Maekawa is rated as a Distinguished expert by MediFind in the treatment of Lactate Dehydrogenase Deficiency. He is also highly rated in 1 other condition, according to our data. His top areas of expertise are Lactate Dehydrogenase Deficiency, Kimura Disease, Fifth Disease, and Rheumatoid Lung Disease.

 
 
 
 
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Distinguished
Highly rated in
8
conditions

Democritus University Of Thrace

Alexandroupoli, ESYE11, GR 68100

Michael Koukourakis is in Alexandroupoli, Greece. Koukourakis is rated as a Distinguished expert by MediFind in the treatment of Lactate Dehydrogenase Deficiency. He is also highly rated in 8 other conditions, according to our data. His top areas of expertise are Cerebral Hypoxia, Lactate Dehydrogenase Deficiency, Proctitis, and Fibroadenoma.

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Who are the sources who wrote this article ?

Published Date:updated Last, February

Published By: National Institutes of Health

What are the Latest Advances for Lactate Dehydrogenase Deficiency?

There is no recent research available for this condition. Please check back because thousands of new papers are published every week and we strive to find and display the most recent relevant research as soon as it is available.