What is the definition of Leydig Cell Testicular Tumor?

A Leydig cell tumor is a tumor of the testicle. It develops from Leydig cells. These are the cells in the testicles that release the male hormone, testosterone.

What are the alternative names for Leydig Cell Testicular Tumor?

Tumor - Leydig cell; Testicular tumor - Leydig

What are the causes for Leydig Cell Testicular Tumor?

The cause of this tumor is unknown. There are no known risk factors for this tumor. Unlike germ cell tumors of the testicles, this tumor does not seem to be linked to undescended testes.

Leydig cell tumors make up a very small number of all testicular tumors. They are most often found in men between 30 and 60 years of age. This tumor is not common in children before puberty, but it may cause early puberty.

What are the symptoms for Leydig Cell Testicular Tumor?

There may be no symptoms.

When symptoms do occur, they can include:

  • Discomfort or pain in the testicle
  • Enlargement of a testicle or change in the way it feels
  • Excess growth of breast tissue (gynecomastia) -- however, this can occur normally in adolescent boys who do not have testicular cancer
  • Heaviness in the scrotum
  • Lump or swelling in either testicle
  • Pain in the lower abdomen or back
  • Not able to father children (infertility)

Symptoms in other parts of the body, such as the lungs, abdomen, pelvis, back, or brain may also occur if the cancer has spread.

What are the current treatments for Leydig Cell Testicular Tumor?

Treatment of a Leydig cell tumor depends on its stage.

  • Stage I cancer has not spread beyond the testicle.
  • Stage II cancer has spread to lymph nodes in the abdomen.
  • Stage III cancer has spread beyond the lymph nodes (possibly as far as the liver, lungs, or brain).

Surgery is done to remove the testicle (orchiectomy). Nearby lymph nodes may also be removed (lymphadenectomy).

Chemotherapy may be used to treat this tumor. As Leydig cell tumors are rare, these treatments have not been studied as much as treatments for other, more common testicular cancers.

What are the support groups for Leydig Cell Testicular Tumor?

Joining a support group where members share common experiences and problems can often help ease the stress of illness.

What is the outlook (prognosis) for Leydig Cell Testicular Tumor?

Testicular cancer is one of the most treatable and curable cancers. Outlook is worse if the tumor is not found early.

What are the possible complications for Leydig Cell Testicular Tumor?

The cancer may spread to other parts of the body. The most common sites include the:

  • Abdomen
  • Lungs
  • Retroperitoneal area (the area near the kidneys behind the other organs in the belly area)
  • Spine

Complications of surgery can include:

  • Bleeding and infection
  • Infertility (if both testicles are removed)

If you are of childbearing age, ask your provider about methods to save your sperm for use at a later date.

When should I contact a medical professional for Leydig Cell Testicular Tumor?

Call your provider if you have symptoms of testicular cancer.

How do I prevent Leydig Cell Testicular Tumor?

Performing testicular self-examination (TSE) each month may help detect testicular cancer at an early stage, before it spreads. Finding testicular cancer early is important for successful treatment and survival.

Male reproductive anatomy


Friedlander TW, Small E. Testicular cancer. In: Niederhuber JE, Armitage JO, Kastan MB, Doroshow JH, Tepper JE, eds. Abeloff's Clinical Oncology. 6th ed. Philadelphia, PA: Elsevier; 2020:chap 83.

National Cancer Institute website. Testicular cancer treatment (PDQ) – health professional version. www.cancer.gov/types/testicular/hp/testicular-treatment-pdq. Updated May 21, 2020. Accessed July 21, 2020.

Stephenson AJ, Gilligan TD. Neoplasms of the testis. In: Partin AW, Dmochowski RR, Kavoussi LR, Peters CA, eds. Campbell-Walsh-Wein Urology. 12th ed. Philadelphia, PA: Elsevier; 2021:chap 76.

  • Journal: The American journal of case reports
  • Published —
Ovarian Leydig Cell Tumor: Cause of Virilization in a Postmenopausal Woman.
  • Condition: Sertoli-Leydig Cell Tumor in Two Siblings with DICER1 Syndrome
  • Journal: Medicine
  • Treatment Used: Surgery
  • Number of Patients: 2
  • Published —
This case report describes two siblings with DICER1 syndrome (tumor predisposition) who developed Sertoli-Leydig cell tumor of the ovary (SLCT) treated with surgery.
Clinical Trial
  • Status: Recruiting
  • Participants: 3400
  • Start Date: December 6, 2016
International Pleuropulmonary Blastoma Registry for PPB, DICER1 and Associated Conditions
Clinical Trial
  • Status: Recruiting
  • Phase: Phase 2
  • Intervention Type: Biological, Drug
  • Participants: 224
  • Start Date: April 12, 2019
A Phase II Study of Ipilimumab, Cabozantinib, and Nivolumab in Rare Genitourinary Cancers (ICONIC)