Learn About Lhermitte-Duclos Disease

What is the definition of Lhermitte-Duclos Disease?
Lhermitte-Duclos disease (LDD) is a very rare, benign (non-cancerous) brain tumor, called a dysplastic gangliocytoma of the cerebellum, that is characterized by abnormal development and enlargement of the cerebellum, and an increased intracranial pressure. LDD manifests most commonly in the third and fourth decades of life. Symptoms may include headache, nausea, cerebellar dysfunction, hydrocephalus, ataxia (problems with movement and coordination), and visual disturbances. Other features may include an enlarged brain (megalencephaly), hydromyelia, extra fingers or toes (polydactyly), partial gigantism, and/or a large tongue (macroglossia). Lhermitte-Duclos disease can occur as an isolated condition; it is also associated with a hereditary cancer syndrome called Cowden disease. Although the exact cause is unknown, mutations in the PTEN gene have been identified in some individuals with LDD.
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What are the alternative names for Lhermitte-Duclos Disease?
  • Dysplastic gangliocytoma of the cerebellum
Who are the top Lhermitte-Duclos Disease Local Doctors?
Elite
Highly rated in
29
conditions

Universität Leipzig

Leipzig, SN, DE 

Wieland Kiess is in Leipzig, Germany. Kiess is rated as an Elite expert by MediFind in the treatment of Lhermitte-Duclos Disease. They are also highly rated in 29 other conditions, according to our data. Their top areas of expertise are Obesity in Children, Obesity, Bannayan-Riley-Ruvalcaba Syndrome, and Lhermitte-Duclos Disease.

Elite
Highly rated in
20
conditions

National Cancer Centre Singapore

Singapore, SG 

Joanne Ngeow is in Singapore, Singapore. Ngeow is rated as an Elite expert by MediFind in the treatment of Lhermitte-Duclos Disease. They are also highly rated in 20 other conditions, according to our data. Their top areas of expertise are Bannayan-Riley-Ruvalcaba Syndrome, Lhermitte-Duclos Disease, Cowden Syndrome, and Giant Mammary Hamartoma.

 
 
 
 
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Distinguished
Highly rated in
27
conditions
Gastroenterology

University Hospital

Columbus, OH 

Peter Stanich is a Gastroenterologist in Columbus, Ohio. Dr. Stanich has been practicing medicine for over 14 years and is rated as a Distinguished doctor by MediFind in the treatment of Lhermitte-Duclos Disease. He is also highly rated in 27 other conditions, according to our data. His top areas of expertise are Cowden Syndrome, Cronkhite-Canada Disease, Bannayan-Riley-Ruvalcaba Syndrome, and Ruvalcaba Syndrome. He is board certified in Gastroenterology and Internal Medicine and licensed to treat patients in Minnesota and Ohio. Dr. Stanich is currently accepting new patients.

What are the latest Lhermitte-Duclos Disease Clinical Trials?
Liquid Biopsy Evaluation and Repository Development at Princess Margaret
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Sirolimus for Cowden Syndrome With Colon Polyposis
What are the Latest Advances for Lhermitte-Duclos Disease?
Gynecological lesions in hereditary cancer predisposition syndromes.
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Isolated intestinal Ganglioneuromatosis: case report and literature review.