Effects of Vasopressor on Cerebral Oxygenation During General Anesthesia in Abdominal Surgery
Status: Recruiting
Location: See location...
Intervention Type: Drug
Study Type: Interventional
Study Phase: Phase 4
SUMMARY
The purpose of this study is to investigate whether norepinephrine(N), phenylephrine(P) or ephedrine(E) have different effect on cerebral oxygenation in abdominal surgery with propofol or sevoflurane.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Maximum Age: 80
Healthy Volunteers: f
View:
• ASA I-III, age 18-80 years
• Elective abdominal surgery
• Signed informed consent
Locations
Other Locations
China
Dalian Municipal Central Hospital
RECRUITING
Dalian
Contact Information
Primary
Liping Han, MD, MSc
han651310@163.com
86-411-84412001
Time Frame
Start Date: 2024-03-05
Estimated Completion Date: 2025-12-05
Participants
Target number of participants: 180
Treatments
Experimental: Ephedrine-Propofol
receive ephedrine 0.15mg/kg (configured concentration 6mg/mL) when MAP was a 20% decrease in baseline blood pressure after both induction of anesthesia and tracheal intubation.
Experimental: Phenylephrine-propofol
receive phenylephrine 2.5ug/kg(configured concentration 100ug/mL) when MAP was a 20% decrease in baseline blood pressure after both induction of anesthesia and tracheal intubation.
Experimental: Norepinephrine-propofol
receive norepinephrine 0.2ug/kg(configured concentration 8μg/ml) when MAP was a 20% decrease in baseline blood pressure after both induction of anesthesia and tracheal intubation.
Active_comparator: Ephedrine-sevoflurane
receive Ephedrine 0.15mg/kg(configured concentration 6mg/mL) when MAP was a 20% decrease in baseline blood pressure after both induction of anesthesia and tracheal intubation.
Active_comparator: Phenylephrine-sevoflurane
receive phenylephrine 2.5ug/kg(configured concentration 80ug/mL) when MAP was a 20% decrease in baseline blood pressure after both induction of anesthesia and tracheal intubation.
Active_comparator: Norepinephrine-sevoflurane
receive norepinephrine 0.2ug/kg(configured concentration 8ug/mL) when MAP was a 20% decrease in baseline blood pressure after both induction of anesthesia and tracheal intubation.
Related Therapeutic Areas
Sponsors
Leads: Dalian Municipal Central Hospital