Learn About Lupus Nephritis

What is the definition of Lupus Nephritis?

Lupus nephritis, which is a kidney disorder, is a complication of systemic lupus erythematosus.

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What are the alternative names for Lupus Nephritis?

Nephritis - lupus; Lupus glomerular disease

What are the causes of Lupus Nephritis?

Systemic lupus erythematosus (SLE, or lupus) is an autoimmune disease. This means there is a problem with the body's immune system.

Normally, the immune system helps protect the body from infection or harmful substances. But in people with an autoimmune disease, the immune system cannot tell the difference between harmful substances and healthy ones. As a result, the immune system attacks otherwise healthy cells and tissues.

SLE may damage different parts of the kidney. This can lead to disorders such as:

  • Interstitial nephritis
  • Nephrotic syndrome
  • Membranous glomerulonephritis
  • Kidney failure
What are the symptoms of Lupus Nephritis?

Symptoms of lupus nephritis include:

  • Blood in the urine
  • Foamy appearance to urine
  • Swelling (edema) of any area of the body
  • High blood pressure
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What are the current treatments for Lupus Nephritis?

The goal of treatment is to improve kidney function and to delay kidney failure.

Medicines may include drugs that suppress the immune system, such as corticosteroids, cyclophosphamide, mycophenolate mofetil, or azathioprine.

You may need dialysis to control symptoms of kidney failure, sometimes for only a while. A kidney transplant may be recommended. People with active lupus should not have a transplant because the condition can occur in the transplanted kidney.

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What is the outlook (prognosis) for Lupus Nephritis?

How well you do depends on the specific form of lupus nephritis. You may have flare-ups, and then times when you do not have any symptoms.

Some people with this condition develop long-term (chronic) kidney failure.

Although lupus nephritis may return in a transplanted kidney, it rarely leads to end-stage kidney disease.

What are the possible complications of Lupus Nephritis?

Complications that may result from lupus nephritis include:

  • Acute renal failure
  • Chronic renal failure
When should I contact a medical professional for Lupus Nephritis?

Contact your provider if you have blood in your urine or swelling of your body.

If you have lupus nephritis, contact your provider if you notice decreased urine output.

How do I prevent Lupus Nephritis?

Treating lupus may help prevent or delay onset of lupus nephritis.

Kidney anatomy
What are the latest Lupus Nephritis Clinical Trials?
Multicenter Prospective Cohort of Kidney Biopsy for Glomerular Disease Research
Summary: Glomerulonephritis (GN) generates an enormous individual and social economic burden. However, the therapeutic options are largely based on clinical and pathological parameters and the individual response to therapy or prognosis is uncertain.~Recently, along with advances in molecular analysis and computational bioinformatics, genomic data from human renal biopsies could provide a strong foundation...
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A Phase III, Randomized, Double-Blind, Placebo-Controlled, Multicenter Study To Evaluate The Efficacy And Safety Of Obinutuzumab In Patients With ISN/RPS 2003 Class III Or IV Lupus Nephritis (REGENCY)
Summary: This study will evaluate the efficacy, safety, and pharmacokinetics of obinutuzumab compared with placebo in patients with International Society of Nephrology/Renal Pathology Society (ISN/RPS) class III or IV lupus nephritis (LN) when added on to standard-of-care therapy consisting of mycophenolate mofetil (MMF) and corticosteroids.
What are the Latest Advances for Lupus Nephritis?
Surgical resection of lupus nephritis with pulmonary Aspergillus infection: a case report and review of the literature.
Summary: Surgical resection of lupus nephritis with pulmonary Aspergillus infection: a case report and review of the literature.
Comparative Effectiveness of Rituximab and Common Induction Therapies for Lupus Nephritis: A Systematic Review and Network Meta-Analysis.
Summary: Comparative Effectiveness of Rituximab and Common Induction Therapies for Lupus Nephritis: A Systematic Review and Network Meta-Analysis.
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Renal outcomes of transient proteinuria in patients with systemic lupus erythematosus treated with corticosteroid therapy alone.
Summary: Renal outcomes of transient proteinuria in patients with systemic lupus erythematosus treated with corticosteroid therapy alone.
Who are the sources who wrote this article ?

Published Date: July 27, 2021
Published By: Walead Latif, MD, Nephrologist and Clinical Associate Professor, Rutgers Medical School, Newark, NJ. Review provided by VeriMed Healthcare Network. Also reviewed by David Zieve, MD, MHA, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team.

What are the references for this article ?

Hahn BH, McMahon M, Wilkinson A, et al. American College of Rheumatology guidelines for screening, case definition, treatment and management of lupus nephritis. Arthritis Care Res (Hoboken). 2012;64(6):797-808. PMCID: 3437757 www.ncbi.nlm.nih.gov/pmc/articles/PMC3437757.

Wadhwani S, Jayne D, Rovin BH. Lupus nephritis. In: Feehally J, Floege J, Tonelli M, Johnson RJ, eds. Comprehensive Clinical Nephrology. 6th ed. Philadelphia, PA: Elsevier; 2019:chap 26.