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Effect of an Intervention Program of Adapted Physical Activity Combined With Compensatory Nutrition in Patients With Constitutional Thinness

Status: Recruiting
Location: See location...
Intervention Type: Behavioral, Other
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

Constitutional Thinness (CT) is a form of stable thinness without malnutrition but with resistance to weight gain, affecting approximately 1% of the general population. The clinical consequences are numerous and the pathophysiology remains poorly understood. Currently, conventional management involves a high-calorie and frequent diet, combined with the avoidance of endurance physical activity, although there is no significant evidence of its effectiveness. Our hypothesis is that an adapted physical activity program (APA) combined with compensatory nutrition (CN) could help these patients gain lean mass (muscle mass).

Eligibility
Participation Requirements
Sex: Female
Minimum Age: 18
Maximum Age: 50
Healthy Volunteers: f
View:

• Gender: Female

• BMI: ≤ 18.5 kg/m²

• Weight Stability: Stable weight for at least 3 months

• Age: 18 to 50 years old at the inclusion visit

• Diagnosed with Constitutional thinness

Locations
Other Locations
France
CHU de Saint-Etienne
RECRUITING
Saint-etienne
Contact Information
Primary
Natacha GERMAIN, PhD
natacha.germain@chu-st-etienne.fr
(0)477120621
Backup
Florence RANCON, Cheffe de projet
florence.rancon@chu-st-etienne.fr
(0) 477829458
Time Frame
Start Date: 2025-07-07
Estimated Completion Date: 2026-06
Participants
Target number of participants: 62
Treatments
Experimental: APA + NC
No_intervention: Control
* 2-week run-in period~* Followed by an 8-week period of conventional management without APA and without NC
Related Therapeutic Areas
Sponsors
Leads: Centre Hospitalier Universitaire de Saint Etienne
Collaborators: Laboratoire Interuniversitaire de Biologie de la Motricité, Target Tape

This content was sourced from clinicaltrials.gov