Learn About Meige Syndrome

What is the definition of Meige Syndrome?
Meige syndrome is a rare, neurological condition characterized by blepharospasm (abnormal movement of the eyelids); oromandibular dystonia (spasms in the jaw and tongue); and sometimes, cervical dystonia. Symptoms and severity can vary. The exact cause of Meige syndrome is unknown, but researchers suspect that it is due to a combination of genetic and environmental factors. Treatment focuses on each person's symptoms and may include drug therapy and/or botulinum A toxin (Botox) injections. Other treatment options, such as deep brain stimulation, are currently being considered.
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What are the alternative names for Meige Syndrome?
  • Meige's syndrome
  • Oral facial dystonia
  • Brueghel syndrome
  • Idiopathic blepharospasm-oromandibular dystonia syndrome
  • Segmental cranial dystonia
  • Blepharospasm-oromandibular dystonia
  • Meige dystonia
  • Blepharospasm - oromandibular dystonia
  • Blepharospasm-oromandibular dystonia syndrome
What are the symptoms of Meige Syndrome?
The specific symptoms, severity and progression of Meige syndrome can vary from person to person. It most often affects middle-aged people and usually is characterized by a combination of blepharospasm and oromandibular dystonia. Blepharospasm is characterized by abnormal, forced blinking and spasms of the eyelids. Eye irritation often occurs in response to various stimuli such as bright lights, wind or fatigue. As the frequency of muscle spasms and contractions increases, it may become progressively harder for affected people to keep their eyes open. Oromandibular dystonia is characterized by involuntary and often forceful contractions of the jaw and tongue, which can make it hard to open or close the mouth. Some people may have clenching of the teeth, displacement of the jaw, grimacing, chin thrusting, or repeated pursing of the lips. Eyelid and facial muscle tone may gradually decline. People with Meige syndrome may also have spasms of the tongue and throat, which can result in the tongue protruding from the mouth and difficulty swallowing. In some cases, muscles in the neck, arms, legs or other areas of the body may become affected.
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What is the outlook (prognosis) for Meige Syndrome?
The long-term outlook (prognosis) for people with Meige syndrome is hard to predict because the specific symptoms, severity and progression of the condition vary from person to person. The prognosis likely depends on several factors, such as age of onset; rate of progression; muscles affected; how early treatment is started; and how a person responds to treatment. Some affected people improve over time. The first symptoms of Meige syndrome may occur anywhere from about 30 to 70 years of age, but they most often occur in the sixth decade of life. Blepharospasm (dystonia of the eyelids) is the most frequent initial complaint of affected people. In most cases, dystonia begins focally. Over time, it may spread to other muscles of the body. When dystonia spreads, it most commonly spreads to areas immediately next to affected muscles. For example, blepharospasm typically spreads to the lower face and jaw muscles. Rarely, dystonia can spread to more distant muscles in the arms and legs. The chance for dystonia to spread is thought to be highest within the first 3 years after onset. However, it can spread more than a decade later. Overall, people with initial onset of blepharospasm have at least a 50% lifetime risk of dystonia spreading. One study found that on average, affected people show gradual worsening of involuntary movements for a little over 2 years, followed by movements slowly improving. The authors of this study suggested that factors that may contribute to a better prognosis include younger age of onset; shorter time between initial onset and progression to the worst symptoms; mild involuntary movements when the symptoms were the worst; and shorter time between onset and starting treatment.
Who are the top Meige Syndrome Local Doctors?
Highly rated in
General Surgery

University Of Arkansas For Medical Sciences Medical Center

Little Rock, AR 

Ozlem Tulunay-Ugur is an Otolaryngologist and a General Surgeon in Little Rock, Arkansas. Dr. Tulunay-Ugur has been practicing medicine for over 25 years and is rated as a Distinguished doctor by MediFind in the treatment of Meige Syndrome. She is also highly rated in 24 other conditions, according to our data. Her top areas of expertise are Spasmodic Dysphonia, Laryngeal Nerve Damage, Perichondritis, and Laryngitis. She is board certified in Otolaryngology and licensed to treat patients in Michigan and Arkansas. Dr. Tulunay-Ugur is currently accepting new patients.

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Institute Of Psychiatry And Neurology

Warsaw, MZ, PL 

Michal Sobstyl is in Warsaw, Poland. Sobstyl is rated as a Distinguished expert by MediFind in the treatment of Meige Syndrome. They are also highly rated in 8 other conditions, according to our data. Their top areas of expertise are Meige Syndrome, Drug Induced Dyskinesia, Focal Dystonia, and Torticollis.

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Nanjing Forestry University

Nanjing, CN 

Jia Ouyang is in Nanjing, China. Ouyang is rated as a Distinguished expert by MediFind in the treatment of Meige Syndrome. They are also highly rated in 2 other conditions, according to our data. Their top areas of expertise are Meige Syndrome, Benign Essential Blepharospasm, Focal Dystonia, and Herniated Disk.

What are the latest Meige Syndrome Clinical Trials?
A Comparative Study of GPI's DBS and Pallidotomy in the Treatment of Meige Syndrome
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What are the Latest Advances for Meige Syndrome?
Regional metabolic and network changes in Meige syndrome.
Outcome of Injection Botulinum Toxin in Blepharospasm.
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Pallidal versus subthalamic deep-brain stimulation for meige syndrome: a retrospective study.