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New Semantic Learning in Patients With Selective Brain Lesions in Temporal Regions: a Behavioural and MRI Study

Status: Recruiting

Location: See all (2) locations...

Intervention Type: Other

Study Type: Interventional

Study Phase: Not Applicable

SUMMARY

THE STUDY AIMS to constitute the largest group of patients with major memory impairment resulting from various etiology and specific lesions of the medial temporal lobe (MTL) and use a combined psychometric and neuroimaging approach to study the factors allowing these patients to successfully learn new semantic information.

Eligibility

Participation Requirements

Sex: All

Minimum Age: 18

Maximum Age: 70

Healthy Volunteers: t

View:

• Patients aged between 18 and 70 years

• Living in France since less than 20 years, being able to understand the French language, and have basic cultural knowledge as evaluated in classical clinical consultation

• Written agreement to participate in the study

• Intellectual capacities compatible with the cognitive tasks and signing of consent

• Affiliation to the French social security system

• For patients: bilateral brain lesion of the medial temporal lobe or the extended hippocampal system

Locations

Other Locations

France

University Hospital of Caen

ACTIVE_NOT_RECRUITING

Caen

University Hospital of Toulouse

RECRUITING

Toulouse

Contact Information

Primary

Jérémie PARIENTE, MD + PHD

pariente.j@chu-toulouse.fr

05 61 77 94 88

Time Frame

Start Date: 2026-04-08

Estimated Completion Date: 2030-01-31

Participants

Target number of participants: 150

Treatments

Experimental: Learning abilities for Patients with an amnesic syndrome

1 MRI session, 2 cognitive research tasks of semantic learning, and neuropsychological assessment.

Active_comparator: Healthy controls

To allow multiple pairing for each patient, a group of 120 healthy controls aged between 18 to 70 years old will be recruited. Thus, it will be possible to compare one given patient to a group of 40 aged-matched subjects.~All healthy volunteers will undergo the same intervention as the patients :~1 MRI session, 2 cognitive research tasks of semantic learning, neuropsychological assessment.

Related Therapeutic Areas

Memory Loss

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