Anti-phosphatidylserine/prothrombin antibodies in patients with polyarteritis nodosa.
Introduction: Anti-phospatidylserine/prothrombin (aPS/PT) antibodies have been described in cutaneous Polyarteritis Nodosa (PAN) in association with specific manifestations.
Objectives: To determine aPS/PT antibodies in patients with PAN and its correlation with clinical manifestations.
Methods: Cross-sectional comparative study including PAN patients and 20 controls (10 Microscopic Polyangiitis and 10 Behçet's disease ). Clinical and demographic variables, treatment, serologic markers, prognosis, activity and damage indexes were evaluated. aPS/PT, anti-cardiolipin (aCL), anti-beta 2 glycoprotein 1 (anti-B2GP1) antibodies, and lupus anticoagulant (LA) were determined.
Results: Fourteen patients with PAN were included, 11 (79%) women, with disease duration of 207 months, and mostly inactive disease. Only one patient with PAN and one with BD were positive for aPS/PT IgG. LA was the most frequent antibody identified. One patient with MPA and one with BD were positive for aCL IgM; one with MPA for anti-B2GP1 IgG, and one with PAN for anti-B2GP1 IgM.
Conclusions: aPS/PT antibodies are not frequent in patients with longstanding inactive PAN.