What is the definition of Miller-Fisher Syndrome?

Miller Fisher syndrome is a rare acquired nerve disease considered to be a variant of Guillain-Barré syndrome. The main features are lack of muscle coordination (ataxia), eye muscle weakness resulting in the inability to move the eyes in several directions (ophthalmoplegia), and the absence of tendon reflexes. Symptoms often start several days after a viral illness. Other symptoms include generalized muscle weakness and respiratory failure. The cause is not known, but it is thought to be an autoimmune disease in which there are autoantibodies that attack the nerves. In most people with Miller Fisher syndrome an antibody (anti-GQ1b) is identified. The presence of these autoantibodies helps confirm the diagnosis of the syndrome. Treatment includes intravenous immunoglobulin (IVIG), plasmapheresis (a plasma exchange procedure in which the antibodies are removed from the blood) and supportive care. The prognosis is usually good, and in most cases, there is almost complete recovery within 6 months. In rare cases, the syndrome may progress and permanent neurological deficits may be present.

What are the alternative names for Miller-Fisher Syndrome?

  • Cranial variant of Guillain-Barré syndrome
  • Cranial variant of GBS
  • Condition: Adults with Guillain-Barré Syndrome (GBS)
  • Journal: Scientific reports
  • Treatment Used: Immunoglobulins, Plasma Exchange, or Corticosteroids
  • Number of Patients: 121
  • Published —
This study investigated treatments for adult patients with Guillain-Barré syndrome (GBS).
  • Journal: Medical archives (Sarajevo, Bosnia and Herzegovina)
  • Published —
Ocular Manifestations of Miller Fisher Syndrome: a Case Report.