Learn About Mucormycosis

What is the definition of Mucormycosis?

Mucormycosis is a fungal infection of the sinuses, brain, or lungs. It occurs in some people with a weakened immune system.

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What are the alternative names for Mucormycosis?

Fungal infection - mucormycosis; Zygomycosis

What are the causes of Mucormycosis?

Mucormycosis is caused by different kinds of fungi that are often found in decaying organic matter. These include spoiled bread, fruit, and vegetables, as well as soil and compost piles. Most people come in contact with the fungus at some time.

However, people with a weakened immune system are more likely to develop mucormycosis. These include people with any of the following conditions:

  • AIDS
  • Burns
  • Diabetes (usually poorly controlled)
  • Leukemia and lymphoma
  • Long-term steroid use
  • Metabolic acidosis
  • Poor nutrition (malnutrition)
  • Use of some medicines

Mucormycosis may involve:

  • A sinus and brain infection called rhinocerebral infection: It may start as a sinus infection, and then lead to the swelling of the nerves that stem from the brain. It may also cause blood clots that block vessels to the brain.
  • A lung infection called pulmonary mucormycosis: Pneumonia gets worse quickly and may spread to the chest cavity, heart, and brain.
  • Other parts of the body: Mucormycosis of the gastrointestinal tract, skin, and kidneys.
What are the symptoms of Mucormycosis?

Symptoms of rhinocerebral mucormycosis include:

  • Eyes that swell and stick out (protrude)
  • Dark scabbing in nasal cavities
  • Fever
  • Headache
  • Mental status changes
  • Redness of skin above sinuses
  • Sinus pain or congestion

Symptoms of lung (pulmonary) mucormycosis include:

  • Cough
  • Coughing blood (occasionally)
  • Fever
  • Shortness of breath

Symptoms of gastrointestinal mucormycosis include:

  • Abdominal pain
  • Blood in the stools
  • Diarrhea
  • Vomiting blood

Symptoms of kidney (renal) mucormycosis include:

  • Fever
  • Pain in the upper abdomen or back

Symptoms of skin (cutaneous) mucormycosis include a single, sometimes painful, hardened area of skin that may have a blackened center.

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What are the current treatments for Mucormycosis?

Surgery should be done right away to remove all dead and infected tissue. Surgery can lead to disfiguration because it may involve removal of the palate, parts of the nose, or parts of the eye. But, without such aggressive surgery, chances of survival are greatly decreased.

You will also receive antifungal medicine, usually amphotericin B, through a vein. After the infection is under control, you may be switched to a different medicine such as posaconazole or isavuconazole.

If you have diabetes, it will be important to get your blood sugar in the normal range.

Who are the top Mucormycosis Local Doctors?
Highly rated in

CECAD Research Center

Kerpener Str 62 
Cologne, DE 

Oliver Cornely is in Cologne, Germany. Cornely is rated as an Elite expert by MediFind in the treatment of Mucormycosis. He is also highly rated in 29 other conditions, according to our data. His top areas of expertise are Mucormycosis, Aspergillosis, Agranulocytosis, and Allergic Bronchopulmonary Aspergillosis.

Highly rated in

University Of Cologne

Department I Of Internal Medicine 
Koeln, NW, DE 

Philipp Koehler is in Koeln, Germany. Koehler is rated as an Elite expert by MediFind in the treatment of Mucormycosis. He is also highly rated in 10 other conditions, according to our data. His top areas of expertise are Mucormycosis, Aspergillosis, Sepsis, and Allergic Bronchopulmonary Aspergillosis.

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Highly rated in

University Of Cologne

Cologne Excellence Cluster On Cellular Stress Responses In Aging Associated Diseases 
Koeln, NW, DE 

Danila Seidel is in Koeln, Germany. Seidel is rated as an Elite expert by MediFind in the treatment of Mucormycosis. They are also highly rated in 2 other conditions, according to our data. Their top areas of expertise are Mucormycosis, Aspergillosis, HIV/AIDS, and Agranulocytosis.

What is the outlook (prognosis) for Mucormycosis?

Mucormycosis has a very high death rate, even when aggressive surgery is done. Risk of death depends on the area of the body involved and your overall health.

What are the possible complications of Mucormycosis?

These complications may occur:

  • Blindness (if the optic nerve is involved)
  • Clotting or blockage of brain or lung blood vessels
  • Death
  • Nerve damage
When should I contact a medical professional for Mucormycosis?

People with weakened immune systems and immune disorders (including diabetes) should seek medical attention if they develop:

  • Fever
  • Headache
  • Sinus pain
  • Eye swelling
  • Any of the other symptoms listed above
How do I prevent Mucormycosis?

Because the fungi that cause mucormycosis are widespread, the best way to prevent this infection is to improve control of the illnesses associated with mucormycosis.

What are the latest Mucormycosis Clinical Trials?
Multicenter Retrospective Cohort Study of Invasive Fungal Filamentous Fungal Infections in Liver Transplant Patients
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A Prospective, Single-arm, Open-label, Non-interventional, Multi-centre, Post Marketing Surveillance (PMS) Study of Cresemba to Evaluate Safety and Effectiveness in Patients With Invasive Aspergillosis or Invasive Mucormycosis in Korea
What are the Latest Advances for Mucormycosis?
Sinonasal mucormycosis and liposomal amphotericin B: A quest for dose optimization.
Adjunctive use of saturated solution of potassium iodide (SSKI) with liposomal amphotericin B (L-AMB) in mucormycosis achieves favorable response, shortened dose and duration of amphotericin: A retrospective study from a COVID-19 tertiary care center.
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Posaconazole or isavuconazole as sole or predominant antifungal therapy for COVID-19-associated mucormycosis. A retrospective observational case series.
Who are the sources who wrote this article ?

Published Date : December 24, 2020
Published By : Jatin M. Vyas, MD, PhD, Assistant Professor in Medicine, Harvard Medical School; Assistant in Medicine, Division of Infectious Disease, Department of Medicine, Massachusetts General Hospital, Boston, MA. Also reviewed by David Zieve, MD, MHA, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team.

What are the references for this article ?

Centers for Disease Control and Prevention website. Mucormycosis. www.cdc.gov/fungal/diseases/mucormycosis/index.html. Updated October 28, 2020. Accessed February 18, 2021.

Kontoyiannis DP. Mucormycosis. In: Goldman L, Schafer AI, eds. Goldman-Cecil Medicine. 26th ed. Philadelphia, PA: Elsevier; 2020:chap 320.

Kontoyiannis DP, Lewis RE. Agents of mucormycosis and entomophthoramycosis. In: Bennett JE, Dolin R, Blaser MJ, eds. Mandell, Douglas, and Bennett's Principles and Practice of Infectious Diseases. 9th ed. Philadelphia, PA: Elsevier; 2020:chap 258.