Comparative study between intralesional injection of MMR, BCG, and candida albicans antigen in treatment of multiple recalcitrant warts.

Journal: Journal Of Cosmetic Dermatology
Treatment Used: MMR, BCG, and Candida Antigen Intralesional Injections
Number of Patients: 90
Published:
MediFind Summary

Summary: This study evaluated the safety and effectiveness of intralesional injection of MMR (mumps, measles, and rubella) antigen, BCG (bacillus Calmette-Guerin) vaccine, and candida antigen for the treatment of patients with multiple warts.

Conclusion: In patients with multiple warts, treatment with intralesional injection of mumps, measles, and rubella antigen, bacillus Calmette-Guerin vaccine, and candida antigen are all effective.

Abstract

Background: Cutaneous warts represent a challenging condition to treat.

Objective: To evaluate the safety and efficacy of intralesional injection of MMR (mumps, measles, and rubella) antigen, BCG (bacillus Calmette-Guerin) vaccine, and candida antigen for the treatment of multiple warts.

Methods: A total of ninety (90) clinically confirmed adult patients complaining of recalcitrant extragenital warts of various sizes and durations were recruited in this randomized clinical trial. They were divided into three groups (A, B, and C). Each group consisted of (30) patients. Group (A) subjects received intralesional MMR injections. Group (B) subjects received intralesional BCG injection and Group (C) received intralesional candida antigen injection.

Results: Full clearance of warts was observed in (73.33%, 70%, and 43.33%) in groups A, B, and C, respectively. Infrequent side effects including pain, erythema, and minimal induration were reported in all groups but did not necessitate termination of treatment.

Conclusions: All the three modalities used demonstrated a simple, safe modality with low adverse events, and with no recurrence. To achieve an optimal response with an ideal immunotherapeutic agent and ideal dose, further comparative studies are warranted and on different populations and larger sample sizes.

Authors
Ramadan Eldahshan, Walaa Mohamed Ashry, Mohamed Elsaie

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