Learn About Neurocutaneous Melanosis

What is the definition of Neurocutaneous Melanosis?
Neurocutaneous melanosis (NCM) is a rare, non-inherited condition of the central nervous system. It is characterized by melanocytic nevi in both the skin and the brain. Two-thirds of people with NCM have giant congenital melanocytic nevi, and the remaining one-third have numerous lesions but no giant lesions. The typical cutaneous lesions are present at birth. Neurological features typically present in the first or second year. Intracranial hypertension is the most common presentation, along with seizures, decreased alertness, and cranial nerve dysfunction.The underlying cause, while not completely understood, is believed to be a primary defect in the neural crest.
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What are the alternative names for Neurocutaneous Melanosis?
  • Neurocutaneous melanosis
  • Melanosis, neurocutaneous
  • Neurocutaneous melanosis syndrome
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Published Date: May 02, 2022
Published By: Genetic and Rare Diseases Informnation Center

What are the Latest Advances for Neurocutaneous Melanosis?
The retrospective molecular analysis of large or giant congenital melanocytic nevi in a group of Polish children.
Summary: The retrospective molecular analysis of large or giant congenital melanocytic nevi in a group of Polish children.
Melanocytic Tumors.
Summary: Melanocytic Tumors.
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Symptomatic neurocutaneous melanosis: mild clinical onset in a teenager.
Summary: Symptomatic neurocutaneous melanosis: mild clinical onset in a teenager.