Learn About Neurohypophyseal Diabetes Insipidus

What is the definition of Neurohypophyseal Diabetes Insipidus?

Neurohypophyseal diabetes insipidus is a disorder of water balance. The body normally balances fluid intake with the excretion of fluid in urine. However, people with neurohypophyseal diabetes insipidus produce too much urine (polyuria), which causes them to be excessively thirsty (polydipsia). Affected people need to urinate frequently, which can disrupt daily activities and sleep.

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What are the causes of Neurohypophyseal Diabetes Insipidus?

The familial form of neurohypophyseal diabetes insipidus is caused by mutations in the AVP gene. This gene provides instructions for making a hormone called vasopressin or antidiuretic hormone (ADH). This hormone, which is produced and stored in the brain, helps control the body's water balance.

How prevalent is Neurohypophyseal Diabetes Insipidus?

Neurohypophyseal diabetes insipidus is thought to be rare, although its exact incidence is unknown. The acquired form occurs much more frequently than the familial form.

Is Neurohypophyseal Diabetes Insipidus an inherited disorder?

Familial neurohypophyseal diabetes insipidus is almost always inherited in an autosomal dominant pattern, which means one copy of the altered AVP gene in each cell is sufficient to cause the disorder.

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What are the latest Neurohypophyseal Diabetes Insipidus Clinical Trials?
Identification and Clinical Relevance of an Oxytocin Deficient State: a Randomized, Crossover, Placebo-controlled, Proof-of-concept Physiopathological Study (CRH Study)
Summary: Oxytocin (OT) is a hypothalamic peptide that enters the peripheral circulation via the posterior pituitary gland. OT plays a key role in regulating appetite, psychopathology, prosocial behavior and sexual function. Hypopituitarism is associated with increased obesity, increased psychopathology, sexual and prosocial dysfunction despite appropriate hormone replacement. A few studies suggest the exis...
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Effects of Intranasal Oxytocin in Patients With Central Diabetes Insipidus - A Pilot Study
Summary: This is a randomized, double-blind, placebo-controlled crossover pilot study of single-dose intranasal oxytocin (4 IU and 24 IU) in 18-60-year-old men and women with central diabetes insipidus to evaluate the effect of oxytocin on anxiety, depression and socioemotional functioning.~Following a screening visit to determine eligibility, participants will return for three main study visits. During th...
Who are the sources who wrote this article ?

Published Date: April 01, 2010Published By: National Institutes of Health

What are the Latest Advances for Neurohypophyseal Diabetes Insipidus?
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