Metabolic and Molecular Responses Under the Effect of Taurine Supplementation With and Without Multicomponent Training in Elderly Women With Sarcopenic Obesity Using the Metabolomics Approach

Status: Not yet recruiting
Intervention Type: Dietary Supplement, Other
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

Sarcopenic obesity is characterized by a progressive decline in muscle mass and an increase in body fat, a condition especially present in the elderly. A significant improvement in metabolic parameters has been observed with the completion of taurine supplementation and also with the practice of physical exercise, but there are no studies associating the interventions mentioned above with the aim of analyzing the metabolic profile of elderly people with sarcopenic obesity. The metabolomics approach allows the study of a whole set of metabolites involved in a biological system. It is believed that taurine supplementation associated with physical exercise is capable of promoting positive contributions to the metabolic profile, investigated through a metabolomics approach. Therefore, the present study seeks to investigate whether taurine supplementation associated with exercise is able to promote contributions to the metabolic profile, through a metabolomics approach, in elderly women with sarcopenic obesity.

Eligibility
Participation Requirements
Sex: Female
Minimum Age: 60
Maximum Age: 75
Healthy Volunteers: No
View:

• BMI between 30 and 40kg/m²;

• Appendicular lean mass below 15 kg;

• Dynamometry below the cutoff point adjusted for sex and BMI (less than or equal to 21kg);

• Sit and stand test below the cut-off point adjusted for the age group, considering the number of repetitions in 30 seconds;

• Present medical certificate to perform physical exercise

Contact Information
Primary
Gabriela F Abud, M.Sc.
gabriela.abud@usp.br
+5516997940181
Time Frame
Start Date: July 2022
Estimated Completion Date: December 2022
Participants
Target number of participants: 60
Treatments
Experimental: Taurine and Exercise (Tau+Ex)
Participants who will receive 3g of taurine supplementation associated with physical training in the period of 16 weeks.
Experimental: Placebo and Exercise (PL+Ex)
Participants who will receive 3g of placebo supplementation associated with physical training in the period of 16 weeks.
Experimental: Taurine (Tau)
Participants who will receive 3g of taurine supplementation in the period of 16 weeks.
Placebo Comparator: Placebo (PL)
Participants who will receive 3g of placebo supplementation in the period of 16 weeks.
Related Therapeutic Areas
Sponsors
Collaborators: Fundação de Amparo à Pesquisa do Estado de São Paulo, Coordenação de Aperfeiçoamento de Pessoal de Nível Superior.
Leads: University of Sao Paulo

This content was sourced from clinicaltrials.gov

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