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Dose Response Effects of Pecan Consumption

Status: Recruiting
Location: See location...
Intervention Type: Other
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

The bioactive compounds contained in tree nuts have been shown to beneficially affect cardiometabolic health outcomes. Pecans contain more total phenols, sterols, and flavonoids than any other tree nut. They also are a rich source of polyunsaturated fatty acids (PUFAs), fiber, vitamin A, vitamin E, folic acid, calcium, magnesium, phosphorus, potassium, and zinc. These bioactive components in pecans are likely the reason for the previously documented improvements in cardiometabolic health. The specific aims of this study are to: * Examine the effect of pecan consumption at doses of 6%, 13%, and 20% of total energy needs on fasting and postprandial blood lipids. * Examine the effect of pecan consumption at doses of 6%, 13%, and 20% of total energy needs on plasma markers associated with overall health. * Examine the effect of pecan consumption at doses of 6%, 13%, and 20% of total energy needs on subjective and physiologic postprandial measures of hunger and satiety. Participants will be asked to: * Consume pecans daily for 28 days or maintain their current habitual diet. * Attend three short weekly visits for fasting blood craws, body measurements, and collect their next week's supply of study materials. * Attend two longer (5 h) testing visits which include consuming a standard breakfast meal and having their blood drawn periodically before and after breakfast. Researchers will compare pecan LOW, pecan MID, pecan HIGH, and the Control group to examine the physiologic effects of incorporating various dosages of pecans into one's diet.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 30
Maximum Age: 75
Healthy Volunteers: t
View:

• 30 to 75-year-old men and women at increased risk of cardiovascular disease. Increased risk of cardiovascular disease will be defined by either elevated cholesterol profiles or overweight/obesity.

• Elevated cholesterol profiles will be defined as: Borderline High and/or at risk in two or more of the following variables (total cholesterol: 180-239 mg/dL, LDL cholesterol 110- 159 mg/dL, triglycerides 130-199 mg/dL) --or---High in total cholesterol (240 mg/dL and higher), LDL (160 mg/dL or higher), or triglycerides (between 200-350 mg/dl).

• Overweight/obesity will be defined by body mass index (overweight \> 28 kg/m2 or obesity 30 kg/m2 or greater).

Locations
United States
Georgia
University of Georgia
RECRUITING
Athens
Contact Information
Primary
Jamie A Cooper, Ph.D.
jamie.cooper@uga.edu
706-542-4378
Time Frame
Start Date: 2023-08-01
Estimated Completion Date: 2026-08-01
Participants
Target number of participants: 80
Treatments
Experimental: Pecan LOW
Participants are given pecans and instructed on how to substitute study foods into their diet to maintain caloric balance.
Experimental: Pecan MID
Participants are given pecans and instructed on how to substitute study foods into their diet to maintain caloric balance.
Experimental: Pecan HIGH
Participants are given pecans and instructed on how to substitute study foods into their diet to maintain caloric balance.
Experimental: CONTROL
Participants are asked to maintain their current habitual diet and avoid any tree nut/peanut consumption for the entire 28-day intervention period.
Related Therapeutic Areas
Sponsors
Leads: University of Georgia

This content was sourced from clinicaltrials.gov

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