The Effects of a 4-week Supplementation With a Ketogenic Nutrient Mix on 24-hour Substrate Metabolism and Muscle Health
This study will investigate the effect of providing a daily ketogenic nutritional supplement in the evening for a prolonged time (4 weeks) to induce a mild ketogenic state during the night in healthy elderly (60-80 years), overweight/obese (BMI: 25-35 kg/m2) individuals with low physical activity, on 24h rhythmicity in energy metabolism as compared to a non-ketogenic, isocaloric control.
• Aged 60-80 years
• Body mass index (BMI) 25-35 kg/m2
• Sedentary lifestyle (not more than 2 hours of structured physical activity per week in the past 3 months)
• Stable dietary habits (no weight loss or gain \> 5 kg in the past 3 months)
• Healthy (as determined by dependent physician based on medical questionnaire)
• Regular sleeping habits (7-9h of daily sleep)