Identification of Phenotypic Factors That Predict Success for Weight Loss and Long-term Weight Maintenance
Status: Recruiting
Location: See location...
Intervention Type: Other
Study Type: Observational
SUMMARY
The Investigational Weight Management Clinic now entitled the Weight Management Program at the University of Michigan was created to identify strategies that will result in cost-effective, long term weight management for overweight and obese individuals. The driving hypothesis of the clinic is that the 'one size fits all' philosophy is untenable with a complex disease such as obesity. The clinic will serve as a portal for patients to choose standard clinical care or to explore alternatives from a variety of clinical studies offered through the clinic. These studies will include further investigations into nutrition, the biological basis of weight and weight management and protocols using approved and experimental pharmaceuticals as well as technologies that aid in self-management of weight.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 15
Maximum Age: 75
Healthy Volunteers: t
View:
• Obese males and females: age \>20 years; Obese population defined as BMI \> or = 27 kg/m2
• Lean population BMI \< 27 but \> 17 kg/m2
• Able and willing to provide written informed consent for the trial
Locations
United States
Michigan
University of Michigan
RECRUITING
Ann Arbor
Contact Information
Primary
Amy E Rothberg, MD, PhD
arothber@med.umich.edu
734-647-5871
Time Frame
Start Date:2009-08
Estimated Completion Date:2026-12
Participants
Target number of participants:3200
Treatments
Lifestyle intervention
Opt-in intervention to include the following procedures, called 'phenotyping' performed at baseline, after 10-15% weight loss from baseline weight or 6 months (whichever comes first) and at end of 2 years while in weight maintenance: oral glucose tolerance test, mixed meal tolerance test, with fasting leptin, biased and unbiased metabolomic profiling, DNA, RNA, muscle and adipose tissue biopsies: measurement of resting energy expenditure by indirect calorimetry; oxidative capacity (V02 peak/max); body composition by Dual Energy X-ray Absorptiometry (DEXA) or air displacement plethysmograph (Bod Pod); inventories of depression and health related quality of life instruments, measures of impulsivity, measures of hunger and appetite, work performance (including presenteeism and absenteeism) and pain survey.