Prospective Population-based Childhood Cohort Study in the Leipzig Area Investigating Genetic, Environmental, and Metabolic Factors and Their Association With the Development of Civilization Diseases
Status: Recruiting
Location: See location...
Study Type: Observational
SUMMARY
The Leipzig Research Centre for Civilization Diseases (LIFE) Child Study is a prospective longitudinal population-based study with a life course approach to health and disease. The LIFE Child Study focuses on two main research objectives: * What are premises of normal growth, development and health in children? * Which factors contribute to the development of non-communicable diseases such as childhood obesity and its co-morbidities, atopy and mental health problems? Detailed assessments will be conducted alongside long-term storage of biological samples in 1,000 pregnant women and more than 5,000 children and their families.
Eligibility
Participation Requirements
Sex: All
Maximum Age: 20
Healthy Volunteers: t
View:
• children with their families and pregnant women of the area of Leipzig
Locations
Other Locations
Germany
LIFE Leipzig Research Centre for Civilization Diseases, University of Leipzig
RECRUITING
Leipzig
Contact Information
Primary
Antje Körner, Prof., MD
antje.koerner@medizin.uni-leipzig.de
Backup
LIFE Child
lifechild@medizin.uni-leipzig.de
Time Frame
Start Date: 2010-10
Estimated Completion Date: 2026-12
Participants
Target number of participants: 7000
Treatments
LIFE Child Health
The LIFE Child HEALTH cohort is a sample of over 5.000 children and adolescents. A basic program that will be carried out annually at each study centre visit. This program includes clinical history (perinatal and past medical history, medications, allergies, immunizations, developmental history and family history) clinical examination, collection of blood, hair, stool and urine samples, anthropometry and different age-dependent questionnaires. Questionnaires are completed by the parents and starting at the age of ten years also by the child itself.
LIFE Child Obesity
The LIFE Child OBESITY cohort is a sample of 500 obese children and adolescents that will be assessed and compared to a lean control group (N=500) with equally detailed phenotyping including metabolic and cardiovascular evaluation. The LIFE Child OBESITY cohort (including the control group) performs the basic program of the LIFE Child HEALTH cohort plus additional parameters such as electrical bioimpedance, assessment of basal metabolic rate, oral glucose tolerance test, liver elastography and spirometry.
LIFE Child Health: Pregnancy/Birth
The LIFE child Pregnancy/Birth cohort is a sample of over 1,200 pregnant women and their offspring. Prenatal examinations are conducted during the 24th to 26th and 34th to 36th week of gestation. During the first year of life, data is collected from children at 3, 6 and 12 month of age.
Authors
Related Therapeutic Areas
Sponsors
Collaborators: Leipzig Research Center for Early Child Development, Free State of Saxony, European Social Fund, Helmholtz Center for Environmental Research Leipzig, Robert Koch Institute Berlin, European Regional Development Fund
Leads: University of Leipzig