Summary: The biological study involves the collection of samples from male and female patients (intraoperative waste tissue, blood and synovial fluid), suffering from mild and moderate-severe OA, who undergo endo or arthro-prosthesis surgery, or arthroplasty, for the identification and characterization of a panel of gender-specific miRNAs. MicroRNAs will be extracted from the samples (chondrocytes, synovio...