Clinical Trials

 

DART: Dual Anti-CTLA-4 and Anti-PD-1 Blockade in Rare Tumors

Intervention Type: Procedure, Biological
Study Type: Interventional
Sponsors: National Cancer Institute (NCI)
Participants: 818
Authors
Hibba Tul Rehman, Robert J. Behrens, Matthew L. Ryan, Michael Humeniuk, Preston D. Steen, Vincent Chung, Kathy D. Miller, Howard M. Gross, Donald S. Gravenor, Howard A. Zaren, Iwona Podzielinski, Igor Puzanov, Jordan D. Berlin, Luca Paoluzzi, Debra M. Prow, Ryan P. Griffin, Dilawar Khan, Daniel C. Cho, Onyekachi H. Ogbonna, Heinz-Josef Lenz, Gregory A. Masters, Thomas J. George, Melissa A. Burgess, Timothy M. Kuzel, Michael A. Schwartz, David M. King, Mei Tang, Russell J. Schilder, Atif M. Hussein, Timothy D. Moore, John M. Schallenkamp, Rex B. Mowat, Bradley C. Carthon, Sajeve S. Thomas, James R. Egner, Christie J. Hilton, Benjamin L. Maughan, Francis J. Cuevas, Missak Haigentz, Jessica Belmonte, John A. Ellerton, Tareq Al Baghdadi, Mitchell Haut, Arturo Loaiza-Bonilla, Christopher W. Ryan, Robert E. Bloom, Thomas E. Lad, Sandip P Patel, Sandip P. Patel, Jeffrey L. Berenberg, Nicholas DiBella, Timothy E. Byun, Daniela A. Bota, Julian C. Schink, Ramya Thota, John M. Wrangle, Wei Song, Kurt Oettel, Qamar U. Zaman, James E. Radford, Asha R. Dhanarajan, Sarah J. Sinclair, Bret E. Friday, Corrine L. Zarwan, Nibal Saad, Raid Aljumaily, Tatjana Kolevska, Saba H. Radhi, Young Kwang Chae, Raymond Thertulien, Christopher M. George, Samer S. Kasbari, Kelly J. Wilkinson, Abhijit B. Saste, John C. McCann, Mebea Aklilu, Joseph Sokhn, Julie R. Brahmer, Gary E. Goodman, Hari A. Deshpande, John A. Keech, Shaker R. Dakhil, Jonathan R. Strosberg, Ari D. Baron, Gini F. Fleming, Asha Karippot, Ralph J. Hauke, Deborah W. Wilbur, Dale R. Shepard, Monica M. Mita, Mark M. Zalupski, Benjamin R. Tan, Alexander Menter, Heidi J. Gray, Charles H. Redfern, Wayne B. Harris, Isaac K. Yeboah, Patrick J. Mansky, William Tse, Edward J. Kim, Robert D. Siegel, Jeffrey K. Giguere, Elizabeth A. Bowhay-Carnes, Kathleen J. Yost, Kristin K. Zorn, Misbah U. Qadir, James H. Feusner, Helen H. Moon, Pam G. Khosla, Andrew W. Pippas, Mark F. Kozloff, Joseph T. Beck, Richard L. Deming, Kathryn C. Hourdequin, Aung Naing, Augusto C. Ochoa, Sachin G. Pai, Sarah W. Gordon, Mitzie-Ann Davis, A P. Chen, Jay W. Carlson, Herta H. Chao, Abdul Hai Mansoor, Stephen V. Liu, Manisha H. Shah, Paul M. Barr, Sarah L. Davis, Eddy S. Yang, Samuel N. Ofori, Chung-Tsen Hsueh, Maria R. Tria Tirona, Barbara Jean B. Haley, Pedro M. Barata, Raed Al-Rajabi, Bryan A. Faller, Ding Wang
Abstract
This phase II trial studies nivolumab and ipilimumab in treating patients with rare tumors. Immunotherapy with monoclonal antibodies, such as nivolumab and ipilimumab, may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. This trial enrolls participants for the following cohorts based on condition: 1. Epithelial tumors of nasal cavity, sinuses, nasopharynx: A) Squamous cell carcinoma with variants of nasal cavity, sinuses, and nasopharynx and trachea (excluding laryngeal, nasopharyngeal cancer [NPC], and squamous cell carcinoma of the head and neck [SCCHN]) B) Adenocarcinoma and variants of nasal cavity, sinuses, and nasopharynx (closed to accrual 07/27/2018) 2. Epithelial tumors of major salivary glands (closed to accrual 03/20/2018) 3. Salivary gland type tumors of head and neck, lip, esophagus, stomach, trachea and lung, breast and other location (closed to accrual) 4. Undifferentiated carcinoma of gastrointestinal (GI) tract 5. Adenocarcinoma with variants of small intestine (closed to accrual 05/10/2018) 6. Squamous cell carcinoma with variants of GI tract (stomach small intestine, colon, rectum, pancreas) (closed to accrual 10/17/2018) 7. Fibromixoma and low grade mucinous adenocarcinoma (pseudomixoma peritonei) of the appendix and ovary (closed to accrual 03/20/2018) 8. Rare pancreatic tumors including acinar cell carcinoma, mucinous cystadenocarcinoma or serous cystadenocarcinoma. Pancreatic adenocarcinoma is not eligible (closed to accrual) 9. Intrahepatic cholangiocarcinoma (closed to accrual 03/20/2018) 10. Extrahepatic cholangiocarcinoma and bile duct tumors (closed to accrual 03/20/2018) 11. Sarcomatoid carcinoma of lung 12. Bronchoalveolar carcinoma lung. This condition is now also referred to as adenocarcinoma in situ, minimally invasive adenocarcinoma, lepidic predominant adenocarcinoma, or invasive mucinous adenocarcinoma 13. Non-epithelial tumors of the ovary: A) Germ cell tumor of ovary B) Mullerian mixed tumor and adenosarcoma (closed to accrual 03/30/2018) 14. Trophoblastic tumor: A) Choriocarcinoma (closed to accrual) 15. Transitional cell carcinoma other than that of the renal, pelvis, ureter, or bladder (closed to accrual) 16. Cell tumor of the testes and extragonadal germ tumors: A) Seminoma and testicular sex cord cancer B) Non seminomatous tumor C) Teratoma with malignant transformation (closed to accrual) 17. Epithelial tumors of penis - squamous adenocarcinoma cell carcinoma with variants of penis (closed to accrual) 18. Squamous cell carcinoma variants of the genitourinary (GU) system 19. Spindle cell carcinoma of kidney, pelvis, ureter 20. Adenocarcinoma with variants of GU system (excluding prostate cancer) (closed to accrual 07/27/2018) 21. Odontogenic malignant tumors 22. Pancreatic neuroendocrine tumor (PNET) (formerly named: Endocrine carcinoma of pancreas and digestive tract.) (closed to accrual) 23. Neuroendocrine carcinoma including carcinoid of the lung (closed to accrual 12/19/2017) 24. Pheochromocytoma, malignant (closed to accrual) 25. Paraganglioma (closed to accrual 11/29/2018) 26. Carcinomas of pituitary gland, thyroid gland parathyroid gland and adrenal cortex (closed to accrual) 27. Desmoid tumors 28. Peripheral nerve sheath tumors and NF1-related tumors (closed to accrual 09/19/2018) 29. Malignant giant cell tumors 30. Chordoma (closed to accrual 11/29/2018) 31. Adrenal cortical tumors (closed to accrual 06/27/2018) 32. Tumor of unknown primary (Cancer of Unknown Primary; CuP) (closed to accrual 12/22/2017) 33. Not Otherwise Categorized (NOC) Rare Tumors [To obtain permission to enroll in the NOC cohort, contact: S1609SC@swog.org] (closed to accrual 03/15/2019) 34. Adenoid cystic carcinoma (closed to accrual 02/06/2018) 35. Vulvar cancer (closed to accrual) 36. MetaPLASTIC carcinoma (of the breast) (closed to accrual) 37. Gastrointestinal stromal tumor (GIST) (closed to accrual 09/26/2018) 38. Perivascular epithelioid cell tumor (PEComa) 39. Apocrine tumors/extramammary Paget's disease (closed to accrual) 40. Peritoneal mesothelioma 41. Basal cell carcinoma (temporarily closed to accrual 04/29/2020) 42. Clear cell cervical cancer 43. Esthenioneuroblastoma (closed to accrual) 44. Endometrial carcinosarcoma (malignant mixed Mullerian tumors) (closed to accrual) 45. Clear cell endometrial cancer 46. Clear cell ovarian cancer (closed to accrual) 47. Gestational trophoblastic disease (GTD) 48. Gallbladder cancer 49. Small cell carcinoma of the ovary, hypercalcemic type 50. PD-L1 amplified tumors 51. Angiosarcoma 52. High-grade neuroendocrine carcinoma (pancreatic neuroendocrine tumor [PNET] should be enrolled in Cohort 22; prostatic neuroendocrine carcinomas should be enrolled into Cohort 53). Small cell lung cancer is not eligible (closed to accrual) 53. Treatment-emergent small-cell neuroendocrine prostate cancer (t-SCNC)
* Consult with your doctor before enrolling in clinical trials.
Facilities
Smilow Cancer Hospital-Derby Care Center - Recruiting
Derby, United States of America
Northwestern University - Recruiting
Chicago, United States of America
Cancer Center of Kansas - Pratt - Recruiting
Pratt, United States of America
Kaiser Permanente Washington - Active, not recruiting
Seattle, United States of America
Ann M Wierman MD LTD - Recruiting
Las Vegas, United States of America
Flaget Memorial Hospital - Recruiting
Bardstown, United States of America
Baptist Memorial Hospital and Cancer Center-Union County - Recruiting
New Albany, United States of America
University of Hawaii Cancer Center - Recruiting
Honolulu, United States of America
Rocky Mountain Cancer Centers-Rose - Recruiting
Denver, United States of America
Lyndon Baines Johnson General Hospital - Recruiting
Houston, United States of America
Inspira Medical Center Vineland - Suspended
Vineland, United States of America
Mercy Clinic-Rolla-Cancer and Hematology - Recruiting
Rolla, United States of America
MultiCare Deaconess Cancer and Blood Specialty Center - Downtown - Suspended
Spokane, United States of America
Academic Hematology Oncology Specialists - Recruiting
Grosse Pointe Woods, United States of America
Deaconess Clinic Downtown - Recruiting
Evansville, United States of America
Central Vermont Medical Center/National Life Cancer Treatment - Recruiting
Berlin, United States of America
Midlands Community Hospital - Recruiting
Papillion, United States of America
Parkland Memorial Hospital - Active, not recruiting
Dallas, United States of America
Comprehensive Cancer Centers of Nevada-Southeast Henderson - Recruiting
Henderson, United States of America
Farmington Health Center - Recruiting
Farmington, United States of America
Saint Luke's Hospital - Recruiting
Chesterfield, United States of America
Henry Ford Cancer Institute-Downriver - Recruiting
Brownstown, United States of America
Dayton Physicians LLC-Atrium - Recruiting
Franklin, United States of America
Penrose-Saint Francis Healthcare - Recruiting
Colorado Springs, United States of America
Thomas Jefferson University Hospital - Recruiting
Philadelphia, United States of America
Illinois CancerCare-Peoria - Recruiting
Peoria, United States of America
TidalHealth Nanticoke / Allen Cancer Center - Recruiting
Seaford, United States of America
Kaiser Permanente - Sacramento - Recruiting
Sacramento, United States of America
Edwards Comprehensive Cancer Center - Recruiting
Huntington, United States of America
Mercy Hospital Joplin - Recruiting
Joplin, United States of America
Hope Cancer Care of Nevada - Recruiting
Las Vegas, United States of America
Ascension Southeast Wisconsin Hospital - Franklin - Recruiting
Franklin, United States of America
Iowa Lutheran Hospital - Recruiting
Des Moines, United States of America
UPMC Washington Hospital Radiation Oncology - Active, not recruiting
Washington, United States of America
Miller-Dwan Hospital - Recruiting
Duluth, United States of America
Delaware Health Center-Grady Cancer Center - Recruiting
Delaware, United States of America
Utah Cancer Specialists-Salt Lake City - Recruiting
Salt Lake City, United States of America
Wesley Medical Center - Recruiting
Wichita, United States of America
Kaiser Permanente-Fresno - Recruiting
Fresno, United States of America
Kaiser Permanente-Fontana - Recruiting
Fontana, United States of America
Dayton Physicians LLC-Wayne - Recruiting
Greenville, United States of America
AdventHealth Infusion Center Asheville - Recruiting
Asheville, United States of America
Advanced Breast Care Center PLLC - Recruiting
Warren, United States of America
Cancer Center of Kansas-Wichita Medical Arts Tower - Recruiting
Wichita, United States of America
Medical Oncology and Hematology Associates-West Des Moines - Recruiting
Clive, United States of America
Cancer Centers of Southwest Oklahoma Research - Recruiting
Lawton, United States of America
Las Vegas Prostate Cancer Center - Recruiting
Las Vegas, United States of America
Allegiance Health - Recruiting
Jackson, United States of America
Saint Vincent Hospital Cancer Center Green Bay - Recruiting
Green Bay, United States of America
Rocky Mountain Cancer Centers-Aurora - Recruiting
Aurora, United States of America
UPMC-Presbyterian Hospital - Active, not recruiting
Pittsburgh, United States of America
Mercy Health Saint Mary's - Recruiting
Grand Rapids, United States of America
Kaiser Permanente-Roseville - Recruiting
Roseville, United States of America
Moffitt Cancer Center - Recruiting
Tampa, United States of America
Essentia Health Saint Mary's Medical Center - Recruiting
Duluth, United States of America
Marshfield Medical Center - Weston - Recruiting
Weston, United States of America
Pulmonary Medicine Center of Chattanooga-Hixson - Suspended
Hixson, United States of America
Lakeview Hospital - Recruiting
Stillwater, United States of America
Prisma Health Cancer Institute - Butternut - Recruiting
Greenville, United States of America
Mercy Hospital - Recruiting
Coon Rapids, United States of America
UPMC-Passavant Hospital - Active, not recruiting
Pittsburgh, United States of America
IHA Hematology Oncology Consultants-Ann Arbor - Recruiting
Ypsilanti, United States of America
South Jordan Health Center - Recruiting
South Jordan, United States of America
Ochsner Medical Center Jefferson - Recruiting
New Orleans, United States of America
Memorial Hospital - Suspended
Chattanooga, United States of America
HealthCare Partners Medical Group Oncology/Hematology-Centennial Hills - Suspended
Las Vegas, United States of America
Queen's Cancer Cenrer - POB I - Recruiting
Honolulu, United States of America
Rocky Mountain Cancer Centers-Thornton - Suspended
Thornton, United States of America
AdventHealth Orlando - Active, not recruiting
Orlando, United States of America
University Cancer Center - Recruiting
Las Vegas, United States of America
Cedars Sinai Medical Center - Recruiting
Los Angeles, United States of America
Cancer and Blood Specialists-Shadow - Suspended
Las Vegas, United States of America
Memorial Medical Center - Recruiting
Modesto, United States of America
Illinois CancerCare-Eureka - Recruiting
Eureka, United States of America
Springfield Regional Cancer Center - Suspended
Springfield, United States of America
Highline Medical Center-Main Campus - Recruiting
Burien, United States of America
Indiana University/Melvin and Bren Simon Cancer Center - Recruiting
Indianapolis, United States of America
Mount Sinai Medical Center - Recruiting
Miami Beach, United States of America
Smilow Cancer Center/Yale-New Haven Hospital - Recruiting
New Haven, United States of America
Legacy Meridian Park Hospital - Recruiting
Tualatin, United States of America
Sutter Auburn Faith Hospital - Recruiting
Auburn, United States of America
Essentia Health Saint Joseph's Medical Center - Recruiting
Brainerd, United States of America
Palo Alto Medical Foundation-Santa Cruz - Recruiting
Santa Cruz, United States of America
Siteman Cancer Center at Christian Hospital - Recruiting
Saint Louis, United States of America
MultiCare Tacoma General Hospital - Recruiting
Tacoma, United States of America
University of California Davis Comprehensive Cancer Center - Recruiting
Sacramento, United States of America
Kingman Regional Medical Center - Recruiting
Kingman, United States of America
Siteman Cancer Center at Saint Peters Hospital - Recruiting
Saint Peters, United States of America
Kaiser Permanente-Fremont - Recruiting
Fremont, United States of America
Ascension Columbia Saint Mary's Hospital Ozaukee - Recruiting
Mequon, United States of America
Baptist Memorial Hospital and Cancer Center-Golden Triangle - Recruiting
Columbus, United States of America
Gibbs Cancer Center-Pelham - Recruiting
Greer, United States of America
Memorial Regional Hospital/Joe DiMaggio Children's Hospital - Recruiting
Hollywood, United States of America
Duluth Clinic Ashland - Recruiting
Ashland, United States of America
Alegent Health Immanuel Medical Center - Recruiting
Omaha, United States of America
Mary Bridge Children's Hospital and Health Center - Suspended
Tacoma, United States of America
Reid Health - Recruiting
Richmond, United States of America
Orlando Health Cancer Institute - Recruiting
Orlando, United States of America
Medical Oncology Hematology Consultants PA - Recruiting
Newark, United States of America
Desert West Surgery - Recruiting
Las Vegas, United States of America
Hawaii Cancer Care Inc-Liliha - Recruiting
Honolulu, United States of America
Western Maryland Regional Medical Center - Recruiting
Cumberland, United States of America
Hurley Medical Center - Recruiting
Flint, United States of America
Lahey Medical Center-Peabody - Recruiting
Peabody, United States of America
Alaska Oncology and Hematology LLC - Recruiting
Anchorage, United States of America
Wexford Health and Wellness Pavilion - Recruiting
Wexford, United States of America
Marshfield Clinic Stevens Point Center - Recruiting
Stevens Point, United States of America
Illinois CancerCare-Pekin - Recruiting
Pekin, United States of America
SIH Cancer Institute - Recruiting
Carterville, United States of America
Trinity Regional Medical Center - Recruiting
Fort Dodge, United States of America
Rocky Mountain Cancer Centers - Pueblo - Suspended
Pueblo, United States of America
Epic Care Partners in Cancer Care - Recruiting
Emeryville, United States of America
Minnesota Oncology Hematology PA-Woodbury - Recruiting
Woodbury, United States of America
Saint Charles Health System - Recruiting
Bend, United States of America
Cancer Center of Kansas - Dodge City - Recruiting
Dodge City, United States of America
Southeastern Medical Oncology Center-Clinton - Recruiting
Clinton, United States of America
Kaiser Permanente-Riverside - Recruiting
Riverside, United States of America
Methodist West Hospital - Recruiting
West Des Moines, United States of America
North Star Lodge Cancer Center at Yakima Valley Memorial Hospital - Suspended
Yakima, United States of America
Southwest Illinois Health Services LLP - Suspended
Swansea, United States of America
Billings Clinic Cancer Center - Recruiting
Billings, United States of America
Ascension Saint Francis Hospital - Recruiting
Milwaukee, United States of America
Kaiser Permanente-Modesto - Recruiting
Modesto, United States of America
Delaware Radiation Oncology - Suspended
Delaware, United States of America
Henry Ford West Bloomfield Hospital - Recruiting
West Bloomfield, United States of America
Memorial Hospital of Carbondale - Recruiting
Carbondale, United States of America
Methodist Medical Center of Illinois - Recruiting
Peoria, United States of America
University of Mississippi Medical Center - Recruiting
Jackson, United States of America
Great Lakes Cancer Management Specialists-Rochester Hills - Suspended
Rochester Hills, United States of America
Kaiser Permanente - Panorama City - Recruiting
Panorama City, United States of America
Broadlawns Medical Center - Recruiting
Des Moines, United States of America
United Hospital - Recruiting
Saint Paul, United States of America
Kaiser Permanente Medical Center-Vacaville - Recruiting
Vacaville, United States of America
Grant Medical Center - Recruiting
Columbus, United States of America
Cancer Care Specialists of Illinois - Decatur - Recruiting
Decatur, United States of America
Kaiser Permanente-Franklin - Recruiting
Denver, United States of America
Rocky Mountain Cancer Centers-Littleton - Recruiting
Littleton, United States of America
University of Kansas Cancer Center-Overland Park - Recruiting
Overland Park, United States of America
Sutter Roseville Medical Center - Recruiting
Roseville, United States of America
MGC Hematology Oncology-Union - Recruiting
Union, United States of America
Hope Cancer Clinic - Recruiting
Livonia, United States of America
Seattle Cancer Care Alliance - Recruiting
Seattle, United States of America
IHA Hematology Oncology Consultants-Canton - Recruiting
Canton, United States of America
Saint Joseph Warren Hospital - Recruiting
Warren, United States of America
Baptist Cancer Center-Grenada - Recruiting
Grenada, United States of America
Community Hospital of Anaconda - Recruiting
Anaconda, United States of America
IHA Hematology Oncology Consultants-Chelsea - Recruiting
Chelsea, United States of America
Saint Mary's Oncology/Hematology Associates of Marlette - Recruiting
Marlette, United States of America
Skagit Valley Hospital - Recruiting
Mount Vernon, United States of America
Vanderbilt Breast Center at One Hundred Oaks - Recruiting
Nashville, United States of America
Rocky Mountain Cancer Centers-Parker - Suspended
Parker, United States of America
Saint John's Hospital - Healtheast - Recruiting
Maplewood, United States of America
North Grove Medical Park - Recruiting
Spartanburg, United States of America
Skagit Valley Hospital Regional Cancer Care Center - Recruiting
Mount Vernon, United States of America
Benefis Healthcare- Sletten Cancer Institute - Recruiting
Great Falls, United States of America
Ochsner Health Center-Summa - Recruiting
Baton Rouge, United States of America
Armes Family Cancer Center - Recruiting
Findlay, United States of America
Ascension Saint Francis - Reiman Cancer Center - Recruiting
Franklin, United States of America
Fairview Southdale Hospital - Recruiting
Edina, United States of America
Toledo Clinic Cancer Centers-Monroe - Recruiting
Monroe, United States of America
Kaiser Permanente-Stockton - Recruiting
Stockton, United States of America
Memorial Medical Center - Recruiting
Springfield, United States of America
University of Kansas Clinical Research Center - Recruiting
Fairway, United States of America
Springfield Clinic - Recruiting
Springfield, United States of America
Mount Carmel East Hospital - Recruiting
Columbus, United States of America
Beebe Health Campus - Recruiting
Rehoboth Beach, United States of America
Cancer Center of Kansas - Newton - Recruiting
Newton, United States of America
University of Michigan Comprehensive Cancer Center - Recruiting
Ann Arbor, United States of America
Harrison HealthPartners Hematology and Oncology-Bremerton - Recruiting
Bremerton, United States of America
Pocono Medical Center - Recruiting
East Stroudsburg, United States of America
Grady Memorial Hospital - Recruiting
Delaware, United States of America
Wayne Hospital - Recruiting
Greenville, United States of America
UPMC-Heritage Valley Health System Beaver - Active, not recruiting
Beaver, United States of America
Arnot Ogden Medical Center/Falck Cancer Center - Active, not recruiting
Elmira, United States of America
Baptist Memorial Hospital and Cancer Center-Oxford - Recruiting
Oxford, United States of America
Essentia Health Cancer Center - Recruiting
Duluth, United States of America
Salina Regional Health Center - Recruiting
Salina, United States of America
Presbyterian - Saint Lukes Medical Center - Health One - Recruiting
Denver, United States of America
University of Oklahoma Health Sciences Center - Recruiting
Oklahoma City, United States of America
Ascension Providence Hospitals - Novi - Recruiting
Novi, United States of America
Illinois CancerCare-Bloomington - Recruiting
Bloomington, United States of America
University of Florida Health Science Center - Gainesville - Recruiting
Gainesville, United States of America
University of Michigan - Brighton Center for Specialty Care - Recruiting
Brighton, United States of America
Hawaii Cancer Care - Savio - Recruiting
'aiea, United States of America
Sutter Solano Medical Center/Cancer Center - Recruiting
Vallejo, United States of America
Marshfield Clinic - Ladysmith Center - Recruiting
Ladysmith, United States of America
Saint Alphonsus Medical Center-Ontario - Recruiting
Ontario, United States of America
Newland Medical Associates-Clarkston - Recruiting
Clarkston, United States of America
Johns Hopkins University/Sidney Kimmel Cancer Center - Recruiting
Baltimore, United States of America
Los Angeles County-USC Medical Center - Recruiting
Los Angeles, United States of America
Saint Ann's Hospital - Recruiting
Westerville, United States of America
Carle Physician Group-Effingham - Recruiting
Effingham, United States of America
University of South Alabama Mitchell Cancer Institute - Recruiting
Mobile, United States of America
Saint Francis Hospital - Recruiting
Greenville, United States of America
Fremont - Rideout Cancer Center - Recruiting
Marysville, United States of America
Providence Saint Vincent Medical Center - Recruiting
Portland, United States of America
Rush - Copley Medical Center - Recruiting
Aurora, United States of America
Blanchard Valley Hospital - Recruiting
Findlay, United States of America
Cancer Center of Kansas - Fort Scott - Suspended
Fort Scott, United States of America
Kaiser Permanente-Santa Rosa - Recruiting
Santa Rosa, United States of America
Mills-Peninsula Medical Center - Suspended
Burlingame, United States of America
Vidant Oncology-Kenansville - Recruiting
Kenansville, United States of America
University of Chicago Medicine-Orland Park - Recruiting
Orland Park, United States of America
UCHealth Memorial Hospital Central - Recruiting
Colorado Springs, United States of America
Rose Medical Center - Suspended
Denver, United States of America
Meharry Medical College - Active, not recruiting
Nashville, United States of America
Wayne Memorial Hospital - Active, not recruiting
Goldsboro, United States of America
Pacific Central Coast Health Center-San Luis Obispo - Recruiting
San Luis Obispo, United States of America
Saint Vincent Hospital Cancer Center at Sturgeon Bay - Recruiting
Sturgeon Bay, United States of America
Ascension Mercy Hospital - Recruiting
Oshkosh, United States of America
Mercy Hospital Oklahoma City - Recruiting
Oklahoma City, United States of America
Olathe Health Cancer Center - Recruiting
Olathe, United States of America
Saint Vincent Hospital Cancer Center at Saint Mary's - Recruiting
Green Bay, United States of America
Kaiser Permanente Los Angeles Medical Center - Recruiting
Los Angeles, United States of America
Kadlec Clinic Hematology and Oncology - Recruiting
Kennewick, United States of America
Straub Clinic and Hospital - Recruiting
Honolulu, United States of America
Loma Linda University Medical Center - Recruiting
Loma Linda, United States of America
University of Chicago Comprehensive Cancer Center - Recruiting
Chicago, United States of America
Saint Luke's Cancer Institute - Nampa - Recruiting
Nampa, United States of America
The University of Kansas Cancer Center-South - Suspended
Kansas City, United States of America
Cancer Center of Kansas-Liberal - Recruiting
Liberal, United States of America
Gene Upshaw Memorial Tahoe Forest Cancer Center - Recruiting
Truckee, United States of America
Northwestern Medicine Lake Forest Hospital - Recruiting
Lake Forest, United States of America
Saint Luke's Cancer Institute - Meridian - Recruiting
Meridian, United States of America
Doylestown Hospital - Recruiting
Doylestown, United States of America
Ascension Saint Michael's Hospital - Recruiting
Stevens Point, United States of America
Sanford Broadway Medical Center - Recruiting
Fargo, United States of America
Forrest General Hospital / Cancer Center - Recruiting
Hattiesburg, United States of America
Mount Carmel Grove City Hospital - Recruiting
Grove City, United States of America
Spartanburg Medical Center - Mary Black Campus - Recruiting
Spartanburg, United States of America
Kaiser Permanente-Lone Tree - Recruiting
Lone Tree, United States of America
Rush-Copley Healthcare Center - Recruiting
Yorkville, United States of America
Saint Joseph Hospital East - Recruiting
Lexington, United States of America
Smilow Cancer Hospital Care Center - Guiford - Recruiting
Guilford, United States of America
Cancer Center of Kansas - Winfield - Recruiting
Winfield, United States of America
HaysMed University of Kansas Health System - Recruiting
Hays, United States of America
Northwestern Medicine Cancer Center Delnor - Recruiting
Geneva, United States of America
Virginia Mason Lynnwood Medical Center - Suspended
Lynnwood, United States of America
New Mexico Oncology Hematology Consultants - Recruiting
Albuquerque, United States of America
Henry Ford Medical Center-Columbus - Recruiting
Novi, United States of America
Jewish Hospital - Recruiting
Louisville, United States of America
Kaiser Permanente-Santa Teresa-San Jose - Recruiting
San Jose, United States of America
Urology Specialists of Nevada - Southwest - Recruiting
Las Vegas, United States of America
Miami Valley Hospital - Recruiting
Dayton, United States of America
Sanford Thief River Falls Medical Center - Recruiting
Thief River Falls, United States of America
Saint Mary's Oncology/Hematology Associates of West Branch - Recruiting
West Branch, United States of America
Urology Specialists of Nevada - Green Valley - Recruiting
Henderson, United States of America
Mercy Hospital Fort Smith - Recruiting
Fort Smith, United States of America
Emory University Hospital Midtown - Recruiting
Atlanta, United States of America
Saint Joseph Mercy Brighton - Recruiting
Brighton, United States of America
Longmont United Hospital - Recruiting
Longmont, United States of America
Saint Louis Cancer and Breast Institute-Ballwin - Recruiting
Ballwin, United States of America
Saint Vincent Healthcare - Suspended
Billings, United States of America
AdventHealth Medical Group Urology at Orlando - Active, not recruiting
Orlando, United States of America
Rocky Mountain Cancer Centers-Boulder - Recruiting
Boulder, United States of America
North Memorial Medical Health Center - Recruiting
Robbinsdale, United States of America
Alta Bates Summit Medical Center-Herrick Campus - Recruiting
Berkeley, United States of America
Bozeman Deaconess Hospital - Recruiting
Bozeman, United States of America
Eastern Maine Medical Center - Recruiting
Bangor, United States of America
Wilcox Memorial Hospital and Kauai Medical Clinic - Recruiting
Lihue, United States of America
Saint Catherine Hospital - Suspended
Garden City, United States of America
Prisma Health Greenville Memorial Hospital - Recruiting
Greenville, United States of America
Sanford Cancer Center Worthington - Recruiting
Worthington, United States of America
Wenatchee Valley Hospital and Clinics - Recruiting
Wenatchee, United States of America
Mission Hope Medical Oncology - Arroyo Grande - Recruiting
Arroyo Grande, United States of America
Marjorie Weinberg Cancer Center at Loyola-Gottlieb - Recruiting
Melrose Park, United States of America
University Medical Center New Orleans - Recruiting
New Orleans, United States of America
Virginia Mason Federal Way Medical Center - Suspended
Federal Way, United States of America
Pali Momi Medical Center - Recruiting
'aiea, United States of America
Urology Specialists of Nevada - Northwest - Recruiting
Las Vegas, United States of America
Lovelace Medical Center-Saint Joseph Square - Recruiting
Albuquerque, United States of America
Piedmont Hospital - Recruiting
Atlanta, United States of America
Ascension All Saints Hospital - Recruiting
Racine, United States of America
National Jewish Health-Main Campus - Suspended
Denver, United States of America
Illinois CancerCare-Dixon - Recruiting
Dixon, United States of America
Louisiana State University Health Science Center - Recruiting
New Orleans, United States of America
Health Partners Inc - Recruiting
Minneapolis, United States of America
IU Health North Hospital - Recruiting
Carmel, United States of America
Ridgeview Medical Center - Recruiting
Waconia, United States of America
Hope Cancer Center - Recruiting
Pontiac, United States of America
Hattiesburg Clinic - Hematology/Oncology Clinic - Recruiting
Hattiesburg, United States of America
Anchorage Oncology Centre - Recruiting
Anchorage, United States of America
Kaiser Permanente-Irvine - Recruiting
Irvine, United States of America
Fairview Lakes Medical Center - Recruiting
Wyoming, United States of America
Anchorage Radiation Therapy Center - Recruiting
Anchorage, United States of America
Rocky Mountain Cancer Centers-Lakewood - Suspended
Lakewood, United States of America
McFarland Clinic PC-Boone - Recruiting
Boone, United States of America
Cancer Center of Kansas - Parsons - Recruiting
Parsons, United States of America
LSU Healthcare Network / Metairie Multi-Specialty Clinic - Recruiting
Metairie, United States of America
Peninsula Cancer Center - Suspended
Poulsbo, United States of America
AdventHealth Altamonte - Active, not recruiting
Altamonte Springs, United States of America
Saint Luke's Cancer Institute - Boise - Recruiting
Boise, United States of America
Cancer Center of Western Wisconsin - Recruiting
New Richmond, United States of America
Metro Health Hospital - Recruiting
Wyoming, United States of America
Huron Medical Center PC - Suspended
Port Huron, United States of America
HealthCare Partners Medical Group Oncology/Hematology-Tenaya - Suspended
Las Vegas, United States of America
Greater Baltimore Medical Center - Recruiting
Baltimore, United States of America
Bay Area Breast Surgeons Inc - Recruiting
Emeryville, United States of America
UPMC-Saint Clair Hospital Cancer Center - Active, not recruiting
Pittsburgh, United States of America
Saint Louis Cancer and Breast Institute-South City - Recruiting
Saint Louis, United States of America
FMH James M Stockman Cancer Institute - Recruiting
Frederick, United States of America
Dayton Physicians LLC-Signal Point - Active, not recruiting
Middletown, United States of America
Ohio State University Comprehensive Cancer Center - Recruiting
Columbus, United States of America
The Women's Imaging Center - Recruiting
Denver, United States of America
Miami Valley Hospital North - Recruiting
Dayton, United States of America
Essentia Health Sandstone - Recruiting
Sandstone, United States of America
Michigan Breast Specialists-Grosse Pointe Woods - Recruiting
Grosse Pointe Woods, United States of America
Genesis Healthcare System Cancer Care Center - Recruiting
Zanesville, United States of America
Southwest Oncology PC - Recruiting
Durango, United States of America
Community Medical Hospital - Recruiting
Missoula, United States of America
Norris Cotton Cancer Center-Nashua - Recruiting
Nashua, United States of America
Upper Valley Medical Center - Recruiting
Troy, United States of America
Ochsner Medical Center Kenner - Recruiting
Kenner, United States of America
Mercy Hospital South - Recruiting
Saint Louis, United States of America
Abbott-Northwestern Hospital - Recruiting
Minneapolis, United States of America
Palo Alto Medical Foundation-Fremont - Recruiting
Fremont, United States of America
Lehigh Valley Hospital-Hazleton - Recruiting
Hazleton, United States of America
Nebraska Methodist Hospital - Recruiting
Omaha, United States of America
UC Irvine Health/Chao Family Comprehensive Cancer Center - Recruiting
Orange, United States of America
Alliance for Childhood Diseases/Cure 4 the Kids Foundation - Recruiting
Las Vegas, United States of America
Cheyenne Regional Medical Center-West - Recruiting
Cheyenne, United States of America
McFarland Clinic PC-Marshalltown - Recruiting
Marshalltown, United States of America
CHI Health Good Samaritan - Recruiting
Kearney, United States of America
Good Samaritan Hospital - Dayton - Suspended
Dayton, United States of America
Lakeland Medical Center Saint Joseph - Recruiting
Saint Joseph, United States of America
Northwest Wisconsin Cancer Center - Recruiting
Ashland, United States of America
Cancer Center of Kansas - Wichita - Recruiting
Wichita, United States of America
Illinois CancerCare-Princeton - Recruiting
Princeton, United States of America
Kaiser Permanente-South Sacramento - Recruiting
Sacramento, United States of America
Spectrum Health at Butterworth Campus - Recruiting
Grand Rapids, United States of America
Saint Francis Regional Medical Center - Recruiting
Shakopee, United States of America
Oncology Hematology Associates of Saginaw Valley PC - Recruiting
Saginaw, United States of America
California Pacific Medical Center-Pacific Campus - Recruiting
San Francisco, United States of America
Billings Clinic-Cody - Recruiting
Cody, United States of America
Sutter Cancer Centers Radiation Oncology Services-Roseville - Recruiting
Roseville, United States of America
Lake Huron Medical Center - Suspended
Port Huron, United States of America
Green Bay Oncology-Manistique - Recruiting
Manistique, United States of America
Onslow Memorial Hospital - Active, not recruiting
Jacksonville, United States of America
Littleton Adventist Hospital - Recruiting
Littleton, United States of America
Comprehensive Cancer Centers of Nevada - Henderson - Recruiting
Henderson, United States of America
Carson Tahoe Regional Medical Center - Recruiting
Carson City, United States of America
CTCA at Western Regional Medical Center - Recruiting
Goodyear, United States of America
Lawrence Memorial Hospital - Recruiting
Lawrence, United States of America
McFarland Clinic PC-Jefferson - Recruiting
Jefferson, United States of America
South Georgia Medical Center/Pearlman Cancer Center - Recruiting
Valdosta, United States of America
Decatur Memorial Hospital - Recruiting
Decatur, United States of America
Overlook Hospital - Recruiting
Summit, United States of America
Southern Illinois University School of Medicine - Recruiting
Springfield, United States of America
Central Care Cancer Center - Bolivar - Suspended
Bolivar, United States of America
Ascension Saint John Hospital - Recruiting
Detroit, United States of America
Cancer Care Center at Island Hospital - Active, not recruiting
Anacortes, United States of America
Saint Vincent Hospital - Recruiting
Erie, United States of America
Good Samaritan Medical Center - Suspended
Lafayette, United States of America
Bronson Methodist Hospital - Recruiting
Kalamazoo, United States of America
Las Vegas Urology - Sunset - Recruiting
Las Vegas, United States of America
Essentia Health Hibbing Clinic - Recruiting
Hibbing, United States of America
Miami Valley Hospital South - Recruiting
Centerville, United States of America
Saint Elizabeth Hospital - Recruiting
Enumclaw, United States of America
Huntsman Cancer Institute/University of Utah - Recruiting
Salt Lake City, United States of America
Emory University Hospital/Winship Cancer Institute - Recruiting
Atlanta, United States of America
Marie Yeager Cancer Center - Recruiting
Saint Joseph, United States of America
Saint Luke's Cancer Institute - Fruitland - Recruiting
Fruitland, United States of America
IHA Hematology Oncology Consultants-Brighton - Recruiting
Brighton, United States of America
Mercy Health - Saint Anne Hospital - Suspended
Toledo, United States of America
AdventHealth Infusion Center Haywood - Recruiting
Clyde, United States of America
Fairview Clinics and Surgery Center Maple Grove - Recruiting
Maple Grove, United States of America
Cancer Care Center of O'Fallon - Recruiting
O'fallon, United States of America
Emory Saint Joseph's Hospital - Recruiting
Atlanta, United States of America
Iowa Methodist Medical Center - Recruiting
Des Moines, United States of America
Providence Saint Joseph Medical Center/Disney Family Cancer Center - Recruiting
Burbank, United States of America
Columbus Oncology and Hematology Associates Inc - Recruiting
Columbus, United States of America
Virginia Mason Bainbridge Island Medical Center - Suspended
Bainbridge Island, United States of America
Tidelands Georgetown Memorial Hospital - Recruiting
Georgetown, United States of America
Providence Regional Cancer System-Lacey - Recruiting
Lacey, United States of America
Providence Regional Cancer System-Shelton - Recruiting
Shelton, United States of America
IU Health West Hospital - Recruiting
Avon, United States of America
West Penn Hospital - Recruiting
Pittsburgh, United States of America
Spokane Valley Cancer Center-Mayfair - Active, not recruiting
Spokane, United States of America
Memorial Hospital North - Recruiting
Colorado Springs, United States of America
Licking Memorial Hospital - Recruiting
Newark, United States of America
Kaiser Permanente-Redwood City - Recruiting
Redwood City, United States of America
Adena Regional Medical Center - Recruiting
Chillicothe, United States of America
UC Irvine Health Cancer Center-Newport - Recruiting
Costa Mesa, United States of America
Kaiser Permanente-Oakland - Recruiting
Oakland, United States of America
University of Rochester - Recruiting
Rochester, United States of America
Prisma Health Cancer Institute - Eastside - Recruiting
Greenville, United States of America
Island Urology - Recruiting
Honolulu, United States of America
Palo Alto Medical Foundation-Gynecologic Oncology - Recruiting
Mountain View, United States of America
AdventHealth Winter Park - Active, not recruiting
Winter Park, United States of America
UPMC Cancer Center at UPMC McKeesport - Active, not recruiting
Mckeesport, United States of America
Renown Regional Medical Center - Recruiting
Reno, United States of America
Southeastern Medical Oncology Center-Goldsboro - Recruiting
Goldsboro, United States of America
Kaiser Permanente-South San Francisco - Recruiting
South San Francisco, United States of America
McFarland Clinic PC - Ames - Recruiting
Ames, United States of America
Carle Physician Group-Mattoon/Charleston - Recruiting
Mattoon, United States of America
Sutter Cancer Centers Radiation Oncology Services-Auburn - Recruiting
Auburn, United States of America
Huron Gastroenterology PC - Recruiting
Ypsilanti, United States of America
Mercy Medical Center - Suspended
Springfield, United States of America
John B Amos Cancer Center - Recruiting
Columbus, United States of America
Dartmouth Hitchcock Medical Center - Recruiting
Lebanon, United States of America
Kaiser Permanente-Deer Valley Medical Center - Recruiting
Antioch, United States of America
Alegent Health Lakeside Hospital - Recruiting
Omaha, United States of America
Providence Alaska Medical Center - Recruiting
Anchorage, United States of America
Minnesota Oncology Hematology PA-Maplewood - Recruiting
Maplewood, United States of America
Ascension Saint Mary's Hospital - Recruiting
Rhinelander, United States of America
Essentia Health - Fosston - Recruiting
Fosston, United States of America
Mercy Medical Center - Recruiting
Canton, United States of America
Toledo Clinic Cancer Centers-Maumee - Active, not recruiting
Maumee, United States of America
Presbyterian Rust Medical Center/Jorgensen Cancer Center - Recruiting
Rio Rancho, United States of America
Jefferson Healthcare - Recruiting
Port Townsend, United States of America
Northwestern Medicine Cancer Center Warrenville - Recruiting
Warrenville, United States of America
Welch Cancer Center - Recruiting
Sheridan, United States of America
Ascension Providence Hospitals - Southfield - Recruiting
Southfield, United States of America
Great Lakes Cancer Management Specialists-Macomb Professional Building - Recruiting
Warren, United States of America
Desert Regional Medical Center - Active, not recruiting
Palm Springs, United States of America
Doctors Hospital - Recruiting
Columbus, United States of America
Saint Luke's Cancer Institute - Twin Falls - Recruiting
Twin Falls, United States of America
Smilow Cancer Hospital-Waterbury Care Center - Recruiting
Waterbury, United States of America
Hawaii Cancer Care Inc - Waterfront Plaza - Recruiting
Honolulu, United States of America
UT Southwestern/Simmons Cancer Center-Fort Worth - Recruiting
Fort Worth, United States of America
Saint Joseph Mercy Hospital - Recruiting
Ann Arbor, United States of America
LDS Hospital - Recruiting
Salt Lake City, United States of America
Essentia Health - Park Rapids - Recruiting
Park Rapids, United States of America
PeaceHealth Saint John Medical Center - Recruiting
Longview, United States of America
Cancer Center of Colorado at Sloan's Lake - Suspended
Denver, United States of America
Saint Francis Cancer Center - Recruiting
Greenville, United States of America
Kaiser Permanente Downtown Commons - Recruiting
Sacramento, United States of America
Providence Newberg Medical Center - Recruiting
Newberg, United States of America
Eisenhower Medical Center - Active, not recruiting
Rancho Mirage, United States of America
OSF Saint Francis Medical Center - Recruiting
Peoria, United States of America
Presbyterian Kaseman Hospital - Recruiting
Albuquerque, United States of America
Strecker Cancer Center-Belpre - Recruiting
Belpre, United States of America
Virginia Commonwealth University/Massey Cancer Center - Recruiting
Richmond, United States of America
Hickman Cancer Center - Recruiting
Adrian, United States of America
Mount Sinai Comprehensive Cancer Center at Aventura - Recruiting
Aventura, United States of America
Marshfield Medical Center-Rice Lake - Recruiting
Rice Lake, United States of America
Piedmont Fayette Hospital - Recruiting
Fayetteville, United States of America
Riverwood Healthcare Center - Recruiting
Aitkin, United States of America
Michigan Breast Specialists-Warren - Recruiting
Warren, United States of America
Saint Charles Health System-Redmond - Recruiting
Redmond, United States of America
Mercy Hospital Washington - Recruiting
Washington, United States of America
Eden Hospital Medical Center - Recruiting
Castro Valley, United States of America
Comprehensive Cancer Centers of Nevada-Summerlin - Recruiting
Las Vegas, United States of America
Tulane University Health Sciences Center - Recruiting
New Orleans, United States of America
Helen F Graham Cancer Center - Recruiting
Newark, United States of America
Saint John Macomb-Oakland Hospital - Recruiting
Warren, United States of America
Legacy Good Samaritan Hospital and Medical Center - Recruiting
Portland, United States of America
Logan Regional Hospital - Recruiting
Logan, United States of America
Mount Carmel Health Center West - Recruiting
Columbus, United States of America
HealthCare Partners Medical Group Oncology/Hematology-Maryland Parkway - Suspended
Las Vegas, United States of America
Rocky Mountain Cancer Centers - Centennial - Recruiting
Centennial, United States of America
Cambridge Medical Center - Recruiting
Cambridge, United States of America
21st Century Oncology-Pontiac - Recruiting
Pontiac, United States of America
Sidney and Lois Eskenazi Hospital - Recruiting
Indianapolis, United States of America
Swedish Medical Center - Recruiting
Englewood, United States of America
Southwest Gynecologic Oncology Associates Inc - Suspended
Albuquerque, United States of America
Forbes Hospital - Recruiting
Monroeville, United States of America
Laura and Isaac Perlmutter Cancer Center at NYU Langone - Recruiting
New York, United States of America
Mission Hope Medical Oncology - Santa Maria - Recruiting
Santa Maria, United States of America
Lahey Hospital and Medical Center - Recruiting
Burlington, United States of America
Mercy Medical Center - Des Moines - Recruiting
Des Moines, United States of America
Great Lakes Cancer Management Specialists-Van Elslander Cancer Center - Recruiting
Grosse Pointe Woods, United States of America
Chilton Medical Center - Recruiting
Pompton, United States of America
Saint Joseph Mercy Oakland - Recruiting
Pontiac, United States of America
Michigan Breast Specialists-Macomb Township - Recruiting
Macomb, United States of America
Saint Alphonsus Cancer Care Center-Caldwell - Recruiting
Caldwell, United States of America
City of Hope Comprehensive Cancer Center - Recruiting
Duarte, United States of America
Marshfield Clinic - Wisconsin Rapids Center - Recruiting
Wisconsin Rapids, United States of America
Ingalls Memorial Hospital - Recruiting
Harvey, United States of America
OptumCare Cancer Care at Seven Hills - Recruiting
Henderson, United States of America
Alegent Health Bergan Mercy Medical Center - Recruiting
Omaha, United States of America
Comprehensive Cancer Centers of Nevada - Recruiting
Las Vegas, United States of America
Urology Specialists of Nevada - Central - Recruiting
Las Vegas, United States of America
Ochsner High Grove - Recruiting
Baton Rouge, United States of America
Baton Rouge General Medical Center - Suspended
Baton Rouge, United States of America
Illinois CancerCare-Galesburg - Recruiting
Galesburg, United States of America
Cancer Center of Kansas-Independence - Recruiting
Independence, United States of America
Lafayette Family Cancer Center-EMMC - Recruiting
Brewer, United States of America
Kettering Medical Center - Recruiting
Kettering, United States of America
Henry Ford Macomb Hospital-Clinton Township - Recruiting
Clinton Township, United States of America
Montefiore Medical Center - Moses Campus - Recruiting
Bronx, United States of America
Marshfield Medical Center-Marshfield - Recruiting
Marshfield, United States of America
Illinois CancerCare-Macomb - Recruiting
Macomb, United States of America
Fairfield Medical Center - Recruiting
Lancaster, United States of America
UPMC-Johnstown/John P. Murtha Regional Cancer Center - Active, not recruiting
Johnstown, United States of America
CHI Saint Vincent Cancer Center Hot Springs - Recruiting
Hot Springs, United States of America
Mills Health Center - Recruiting
San Mateo, United States of America
Valley Medical Center - Recruiting
Renton, United States of America
MedStar Georgetown University Hospital - Recruiting
Washington, United States of America
Caro Cancer Center - Recruiting
Caro, United States of America
Henry Ford Medical Center-Fairlane - Recruiting
Dearborn, United States of America
Hennepin County Medical Center - Recruiting
Minneapolis, United States of America
Saint Mary's Hospital and Regional Medical Center - Suspended
Grand Junction, United States of America
UPMC Cancer Center at UPMC Northwest - Active, not recruiting
Seneca, United States of America
Munson Medical Center - Recruiting
Traverse City, United States of America
Rocky Mountain Cancer Centers-Longmont - Recruiting
Longmont, United States of America
ProMedica Toledo Hospital/Russell J Ebeid Children's Hospital - Recruiting
Toledo, United States of America
Bronson Battle Creek - Recruiting
Battle Creek, United States of America
Cancer Therapy and Integrative Medicine - Suspended
Las Vegas, United States of America
University of Vermont and State Agricultural College - Recruiting
Burlington, United States of America
Illinois CancerCare-Carthage - Recruiting
Carthage, United States of America
University of Texas Health Science Center at San Antonio - Recruiting
San Antonio, United States of America
Sutter Cancer Centers Radiation Oncology Services-Vacaville - Recruiting
Vacaville, United States of America
Kaiser Permanente-Rock Creek - Recruiting
Lafayette, United States of America
Northwest Cancer Clinic - Suspended
Kennewick, United States of America
OSF Saint Francis Radiation Oncology at Peoria Cancer Center - Recruiting
Peoria, United States of America
Freeman Health System - Recruiting
Joplin, United States of America
Smilow Cancer Hospital Care Center-Trumbull - Recruiting
Trumbull, United States of America
Fairview Ridges Hospital - Recruiting
Burnsville, United States of America
Pacific Gynecology Specialists - Recruiting
Seattle, United States of America
Las Vegas Urology - Pebble - Recruiting
Henderson, United States of America
Mountain Blue Cancer Care Center - Swedish - Recruiting
Englewood, United States of America
Saint Francis Medical Center - Recruiting
Cape Girardeau, United States of America
UT Southwestern/Simmons Cancer Center-Dallas - Active, not recruiting
Dallas, United States of America
Henry Ford Hospital - Recruiting
Detroit, United States of America
Cancer Center at Saint Joseph's - Recruiting
Phoenix, United States of America
Boulder Community Foothills Hospital - Recruiting
Boulder, United States of America
Christiana Care Health System-Concord Health Center - Recruiting
Chadds Ford, United States of America
PeaceHealth Southwest Medical Center - Recruiting
Vancouver, United States of America
21st Century Oncology-Fort Apache - Recruiting
Las Vegas, United States of America
Baystate Medical Center - Recruiting
Springfield, United States of America
Epic Care-Dublin - Recruiting
Dublin, United States of America
Washington University School of Medicine - Recruiting
Saint Louis, United States of America
Ascension Saint Joseph Hospital - Recruiting
Tawas City, United States of America
Comprehensive Cancer Centers of Nevada - Town Center - Recruiting
Las Vegas, United States of America
Prisma Health Cancer Institute - Spartanburg - Recruiting
Boiling Springs, United States of America
Kootenai Medical Center - Recruiting
Coeur D'alene, United States of America
Saint Mary Mercy Hospital - Recruiting
Livonia, United States of America
Riverside Methodist Hospital - Recruiting
Columbus, United States of America
Contra Costa Regional Medical Center - Recruiting
Martinez, United States of America
Rice Memorial Hospital - Recruiting
Willmar, United States of America
UPMC-Shadyside Hospital - Active, not recruiting
Pittsburgh, United States of America
Advocate Illinois Masonic Medical Center - Recruiting
Chicago, United States of America
Kalispell Regional Medical Center - Recruiting
Kalispell, United States of America
Greater Regional Medical Center - Recruiting
Creston, United States of America
PeaceHealth Saint Joseph Medical Center - Recruiting
Bellingham, United States of America
Great Falls Clinic - Recruiting
Great Falls, United States of America
Saint Elizabeth Youngstown Hospital - Recruiting
Youngstown, United States of America
Denver Health Medical Center - Suspended
Denver, United States of America
MultiCare Deaconess Cancer and Blood Specialty Center - Valley - Suspended
Spokane Valley, United States of America
Kaiser Permanente-Walnut Creek - Recruiting
Walnut Creek, United States of America
Gundersen Lutheran Medical Center - Recruiting
La Crosse, United States of America
Tacoma/Valley Radiation Oncology Centers-Jackson Hall - Suspended
Tacoma, United States of America
Prisma Health Cancer Institute - Faris - Recruiting
Greenville, United States of America
Vidant Oncology-Kinston - Recruiting
Kinston, United States of America
McKee Medical Center - Recruiting
Loveland, United States of America
Cancer Center of Kansas - Salina - Recruiting
Salina, United States of America
Saint Joseph Radiation Oncology Resource Center - Recruiting
Lexington, United States of America
Mercy Hospital Saint Louis - Recruiting
Saint Louis, United States of America
Legacy Mount Hood Medical Center - Recruiting
Gresham, United States of America
Smilow Cancer Hospital Care Center at Saint Francis - Recruiting
Hartford, United States of America
Crossroads Cancer Center - Recruiting
Effingham, United States of America
Saint Vincent Hospital Cancer Center at Marinette - Suspended
Marinette, United States of America
Anchorage Associates in Radiation Medicine - Recruiting
Anchorage, United States of America
Mercy Cancer Center-West Lakes - Recruiting
Clive, United States of America
Siteman Cancer Center-South County - Recruiting
Saint Louis, United States of America
Springfield Regional Medical Center - Suspended
Springfield, United States of America
Cancer and Blood Specialists-Tenaya - Suspended
Las Vegas, United States of America
Harrison Medical Center - Recruiting
Bremerton, United States of America
Kaiser Permanente-Cadillac - Recruiting
Los Angeles, United States of America
Beaumont Hospital - Dearborn - Suspended
Dearborn, United States of America
Creighton University Medical Center - Recruiting
Omaha, United States of America
Swedish Cancer Institute-Issaquah - Recruiting
Issaquah, United States of America
University of New Mexico Cancer Center - Recruiting
Albuquerque, United States of America
Norris Cotton Cancer Center-North - Active, not recruiting
Saint Johnsbury, United States of America
Montefiore Medical Center-Einstein Campus - Recruiting
Bronx, United States of America
PCR Oncology - Recruiting
Arroyo Grande, United States of America
Colorado Blood Cancer Institute - Recruiting
Denver, United States of America
University of Colorado Hospital - Recruiting
Aurora, United States of America
Cancer and Blood Specialists-Henderson - Recruiting
Henderson, United States of America
Lakeland Hospital Niles - Recruiting
Niles, United States of America
Holy Cross Hospital - Recruiting
Fort Lauderdale, United States of America
Kaiser Permanente Dublin - Recruiting
Dublin, United States of America
Cancer Center of Kansas-Manhattan - Recruiting
Manhattan, United States of America
OptumCare Cancer Care at Fort Apache - Recruiting
Las Vegas, United States of America
Genesee Hematology Oncology PC - Recruiting
Flint, United States of America
Southern Ohio Medical Center - Recruiting
Portsmouth, United States of America
UC San Diego Moores Cancer Center - Recruiting
La Jolla, United States of America
Summit Cancer Care-Candler - Recruiting
Savannah, United States of America
Toledo Clinic Cancer Centers-Toledo - Recruiting
Toledo, United States of America
Cancer Center of Kansas-Kingman - Recruiting
Kingman, United States of America
Sutter Cancer Research Consortium - Suspended
Novato, United States of America
Smilow Cancer Hospital Care Center-Fairfield - Recruiting
Fairfield, United States of America
Marshfield Clinic-Chippewa Center - Recruiting
Chippewa Falls, United States of America
OSF Saint Francis Radiation Oncology at Pekin Cancer Treatment Center - Recruiting
Pekin, United States of America
Walter Knox Memorial Hospital - Recruiting
Emmett, United States of America
Beebe South Coastal Health Campus - Recruiting
Frankford, United States of America
OhioHealth Mansfield Hospital - Recruiting
Mansfield, United States of America
Regions Hospital - Recruiting
Saint Paul, United States of America
National Institutes of Health Clinical Center - Recruiting
Bethesda, United States of America
Alaska Women's Cancer Care - Recruiting
Anchorage, United States of America
Tacoma/Valley Radiation Oncology Centers-Gig Harbor - Suspended
Gig Harbor, United States of America
Lake Region Healthcare Corporation-Cancer Care - Recruiting
Fergus Falls, United States of America
University of Washington Medical Center - Montlake - Recruiting
Seattle, United States of America
Saint James Community Hospital and Cancer Treatment Center - Suspended
Butte, United States of America
Franciscan Research Center-Northwest Medical Plaza - Recruiting
Tacoma, United States of America
UPMC-Saint Margaret - Active, not recruiting
Pittsburgh, United States of America
Stamford Hospital/Bennett Cancer Center - Active, not recruiting
Stamford, United States of America
Truman Medical Centers - Recruiting
Kansas City, United States of America
Jefferson Hospital - Recruiting
Jefferson Hills, United States of America
Spartanburg Medical Center - Recruiting
Spartanburg, United States of America
Sibley Memorial Hospital - Recruiting
Washington, United States of America
Cancer Center of Kansas - El Dorado - Recruiting
El Dorado, United States of America
Commonwealth Cancer Center-Corbin - Recruiting
Corbin, United States of America
Kaiser Permanente Northwest - Recruiting
Portland, United States of America
Dayton Physicians LLC-Wilson - Active, not recruiting
Sidney, United States of America
Spokane Valley Cancer Center-Mission - Active, not recruiting
Spokane, United States of America
Christiana Care Health System-Christiana Hospital - Recruiting
Newark, United States of America
Baptist Memorial Hospital and Cancer Center-Collierville - Recruiting
Collierville, United States of America
Kaiser Permanente-San Rafael - Recruiting
San Rafael, United States of America
Marietta Memorial Hospital - Recruiting
Marietta, United States of America
TriHealth Cancer Institute-Anderson - Recruiting
Cincinnati, United States of America
Spectrum Health Reed City Hospital - Recruiting
Reed City, United States of America
Central Care Cancer Center - Great Bend - Suspended
Great Bend, United States of America
Stony Brook University Medical Center - Suspended
Stony Brook, United States of America
Midwestern Regional Medical Center - Recruiting
Zion, United States of America
Swedish Medical Center-First Hill - Recruiting
Seattle, United States of America
Loyola Center for Health at Burr Ridge - Recruiting
Burr Ridge, United States of America
Coffeyville Regional Medical Center - Suspended
Coffeyville, United States of America
Memorial GYN Plus - Suspended
Ooltewah, United States of America
SCL Health Saint Joseph Hospital - Suspended
Denver, United States of America
Alta Bates Summit Medical Center - Summit Campus - Recruiting
Oakland, United States of America
Saint Alphonsus Medical Center-Nampa - Recruiting
Nampa, United States of America
National Jewish Health-Western Hematology Oncology - Suspended
Golden, United States of America
Medical University of South Carolina - Recruiting
Charleston, United States of America
Indu and Raj Soin Medical Center - Recruiting
Beavercreek, United States of America
Providence Willamette Falls Medical Center - Suspended
Oregon City, United States of America
Queen's Medical Center - Recruiting
Honolulu, United States of America
Newark Radiation Oncology - Recruiting
Newark, United States of America
Prisma Health Cancer Institute - Easley - Recruiting
Easley, United States of America
South Pointe Hospital - Recruiting
Warrensville Heights, United States of America
Kaiser Permanente Moanalua Medical Center - Recruiting
Honolulu, United States of America
Missouri Baptist Outpatient Center-Sunset Hills - Recruiting
Sunset Hills, United States of America
Hematology/Oncology Clinic PLLC - Recruiting
Baton Rouge, United States of America
Saint Francis Hospital - Recruiting
Federal Way, United States of America
Missouri Baptist Sullivan Hospital - Recruiting
Sullivan, United States of America
Saint Peter's Community Hospital - Suspended
Helena, United States of America
Keck Medical Center of USC Pasadena - Recruiting
Pasadena, United States of America
Providence Regional Cancer System-Yelm - Recruiting
Yelm, United States of America
Roswell Park Cancer Institute - Recruiting
Buffalo, United States of America
MetroHealth Medical Center - Recruiting
Cleveland, United States of America
John H Stroger Jr Hospital of Cook County - Recruiting
Chicago, United States of America
Low Country Cancer Care Associates PC - Suspended
Savannah, United States of America
Rocky Mountain Cancer Centers-Penrose - Recruiting
Colorado Springs, United States of America
Kaiser Permanente-Bellflower - Recruiting
Bellflower, United States of America
Saint Vincent Frontier Cancer Center - Suspended
Billings, United States of America
Sunrise Hospital and Medical Center - Recruiting
Las Vegas, United States of America
Park Nicollet Clinic - Saint Louis Park - Recruiting
Saint Louis Park, United States of America
Kaiser Permanente - Harbor City - Recruiting
Harbor City, United States of America
Sanford USD Medical Center - Sioux Falls - Recruiting
Sioux Falls, United States of America
Marshfield Clinic Cancer Center at Sacred Heart - Suspended
Eau Claire, United States of America
Jewish Hospital Medical Center South - Recruiting
Shepherdsville, United States of America
Providence Saint Mary Regional Cancer Center - Recruiting
Walla Walla, United States of America
Saint Alphonsus Cancer Care Center-Boise - Recruiting
Boise, United States of America
Rocky Mountain Cancer Centers-Greenwood Village - Suspended
Greenwood Village, United States of America
Marshfield Clinic-Wausau Center - Recruiting
Wausau, United States of America
Missouri Baptist Medical Center - Recruiting
Saint Louis, United States of America
Sanford Roger Maris Cancer Center - Recruiting
Fargo, United States of America
Centralia Oncology Clinic - Recruiting
Centralia, United States of America
Sharp Memorial Hospital - Recruiting
San Diego, United States of America
Kaiser Permanente-Richmond - Recruiting
Richmond, United States of America
Parkland Health Center - Farmington - Recruiting
Farmington, United States of America
Mercy Hospital Springfield - Recruiting
Springfield, United States of America
Ascension Calumet Hospital - Recruiting
Chilton, United States of America
Palo Alto Medical Foundation-Sunnyvale - Recruiting
Sunnyvale, United States of America
First Dayton Cancer Care - Suspended
Kettering, United States of America
Queen's Cancer Center - Kuakini - Recruiting
Honolulu, United States of America
Morristown Medical Center - Recruiting
Morristown, United States of America
Genesys Hurley Cancer Institute - Recruiting
Flint, United States of America
University of Alabama at Birmingham Cancer Center - Recruiting
Birmingham, United States of America
Margaret R Pardee Memorial Hospital - Recruiting
Hendersonville, United States of America
MultiCare Auburn Medical Center - Recruiting
Auburn, United States of America
MultiCare Good Samaritan Hospital - Recruiting
Puyallup, United States of America
Bethesda North Hospital - Recruiting
Cincinnati, United States of America
University of Kansas Cancer Center - North - Recruiting
Kansas City, United States of America
Cox Cancer Center Branson - Suspended
Branson, United States of America
Palo Alto Medical Foundation-Camino Division - Recruiting
Mountain View, United States of America
Dixie Medical Center Regional Cancer Center - Recruiting
Saint George, United States of America
Ascension Via Christi - Pittsburg - Recruiting
Pittsburg, United States of America
Providence Portland Medical Center - Recruiting
Portland, United States of America
Chancellor Center for Oncology - Recruiting
Newburgh, United States of America
Kaiser Permanente-Ontario - Recruiting
Ontario, United States of America
Hope Cancer Care of Nevada-Pahrump - Recruiting
Pahrump, United States of America
Rocky Mountain Cancer Centers-Sky Ridge - Recruiting
Lone Tree, United States of America
East Jefferson General Hospital - Recruiting
Metairie, United States of America
Porter Adventist Hospital - Recruiting
Denver, United States of America
M D Anderson Cancer Center - Recruiting
Houston, United States of America
Parkview Regional Medical Center - Recruiting
Fort Wayne, United States of America
Kansas City Veterans Affairs Medical Center - Suspended
Kansas City, United States of America
CHI Health Saint Francis - Recruiting
Grand Island, United States of America
SCL Health Lutheran Medical Center - Suspended
Wheat Ridge, United States of America
Alaska Breast Care and Surgery LLC - Recruiting
Anchorage, United States of America
AdventHealth Hendersonville - Recruiting
Hendersonville, United States of America
Virginia Mason Medical Center - Suspended
Seattle, United States of America
Good Samaritan Regional Health Center - Recruiting
Mount Vernon, United States of America
Lehigh Valley Hospital - Muhlenberg - Recruiting
Bethlehem, United States of America
Parker Adventist Hospital - Recruiting
Parker, United States of America
Oncology Hematology Care Inc-Kenwood - Recruiting
Cincinnati, United States of America
UPMC-Coraopolis/Heritage Valley Radiation Oncology - Active, not recruiting
Moon, United States of America
Saint Elizabeth Regional Medical Center - Recruiting
Lincoln, United States of America
Orion Cancer Care - Recruiting
Findlay, United States of America
AIS Cancer Center at San Joaquin Community Hospital - Suspended
Bakersfield, United States of America
University of Kansas Hospital-Indian Creek Campus - Recruiting
Overland Park, United States of America
North Coast Cancer Care - Recruiting
Sandusky, United States of America
Intermountain Medical Center - Recruiting
Murray, United States of America
Saint Mary's Regional Medical Center - Recruiting
Reno, United States of America
Sutter Medical Center Sacramento - Recruiting
Sacramento, United States of America
The Mark H Zangmeister Center - Recruiting
Columbus, United States of America
Fred Hutchinson Cancer Research Center - Recruiting
Seattle, United States of America
Heartland Regional Medical Center - Recruiting
Saint Joseph, United States of America
Oregon Health and Science University - Recruiting
Portland, United States of America
21st Century Oncology - Recruiting
Las Vegas, United States of America
Sutter Pacific Medical Foundation - Recruiting
Santa Rosa, United States of America
University of Arkansas for Medical Sciences - Recruiting
Little Rock, United States of America
Highlands Oncology Group - Recruiting
Rogers, United States of America
UT Southwestern Clinical Center at Richardson/Plano - Active, not recruiting
Richardson, United States of America
Grand Valley Oncology - Active, not recruiting
Grand Junction, United States of America
Borgess Medical Center - Recruiting
Kalamazoo, United States of America
Radiation Oncology Associates - Recruiting
Reno, United States of America
University of Pittsburgh Cancer Institute (UPCI) - Recruiting
Pittsburgh, United States of America
Kaiser Permanente-San Diego Zion - Recruiting
San Diego, United States of America
Mount Sinai Hospital Medical Center - Recruiting
Chicago, United States of America
Sanford Joe Lueken Cancer Center - Recruiting
Bemidji, United States of America
McFarland Clinic PC-Trinity Cancer Center - Recruiting
Fort Dodge, United States of America
CoxHealth South Hospital - Recruiting
Springfield, United States of America
Kootenai Cancer Clinic - Recruiting
Sandpoint, United States of America
OhioHealth Marion General Hospital - Recruiting
Marion, United States of America
Providence Regional Cancer System-Aberdeen - Recruiting
Aberdeen, United States of America
Christus Saint Vincent Regional Cancer Center - Active, not recruiting
Santa Fe, United States of America
Presence Saint Mary's Hospital - Active, not recruiting
Kankakee, United States of America
Ascension Via Christi Hospitals Wichita - Recruiting
Wichita, United States of America
Queen's Cancer Center - Pearlridge - Recruiting
'aiea, United States of America
Associates In Womens Health - Suspended
Wichita, United States of America
Saint Mary Corwin Medical Center - Recruiting
Pueblo, United States of America
Kaiser Permanente San Leandro - Recruiting
San Leandro, United States of America
Kaiser Permanente-Baldwin Park - Recruiting
Baldwin Park, United States of America
Illinois CancerCare-Peru - Recruiting
Peru, United States of America
Kapiolani Medical Center for Women and Children - Recruiting
Honolulu, United States of America
Green Bay Oncology - Escanaba - Recruiting
Escanaba, United States of America
USC / Norris Comprehensive Cancer Center - Recruiting
Los Angeles, United States of America
Baptist Memorial Hospital and Fowler Family Cancer Center - Jonesboro - Recruiting
Jonesboro, United States of America
Sanford Cancer Center Oncology Clinic - Recruiting
Sioux Falls, United States of America
Cleveland Clinic Foundation - Recruiting
Cleveland, United States of America
Cancer Center of Kansas - Chanute - Recruiting
Chanute, United States of America
Valley View Hospital Cancer Center - Active, not recruiting
Glenwood Springs, United States of America
Kaiser Permanente Medical Center - Santa Clara - Recruiting
Santa Clara, United States of America
Hematology Oncology Consultants-Clarkston - Recruiting
Clarkston, United States of America
Essentia Health Cancer Center-South University Clinic - Recruiting
Fargo, United States of America
West Michigan Cancer Center - Recruiting
Kalamazoo, United States of America
Fairview Northland Medical Center - Recruiting
Princeton, United States of America
North Colorado Medical Center - Recruiting
Greeley, United States of America
Monticello Cancer Center - Recruiting
Monticello, United States of America
Knox Community Hospital - Recruiting
Mount Vernon, United States of America
Henry Ford Macomb Health Center - Shelby Township - Recruiting
Shelby, United States of America
Frederick Memorial Hospital - Recruiting
Frederick, United States of America
Sanford Bismarck Medical Center - Recruiting
Bismarck, United States of America
AdventHealth Kissimmee - Active, not recruiting
Kissimmee, United States of America
Mary Greeley Medical Center - Recruiting
Ames, United States of America
Cancer Center of Kansas - Wellington - Recruiting
Wellington, United States of America
Monroe Cancer Center - Recruiting
Monroe, United States of America
Toledo Radiation Oncology at Northwest Ohio Onocolgy Center - Active, not recruiting
Maumee, United States of America
Ascension Southeast Wisconsin Hospital - Saint Joseph Campus - Recruiting
Milwaukee, United States of America
OptumCare Cancer Care at MountainView - Recruiting
Las Vegas, United States of America
Holy Family Memorial Hospital - Suspended
Manitowoc, United States of America
Southeast Cancer Center - Recruiting
Cape Girardeau, United States of America
Sutter Cancer Centers Radiation Oncology Services-Cameron Park - Recruiting
Cameron Park, United States of America
MultiCare Deaconess Cancer and Blood Specialty Center - North - Suspended
Spokane, United States of America
Jewish Hospital Medical Center Northeast - Recruiting
Louisville, United States of America
Las Vegas Urology - Green Valley - Recruiting
Henderson, United States of America
UPMC Uniontown Hospital Radiation Oncology - Active, not recruiting
Uniontown, United States of America
Yale University - Recruiting
New Haven, United States of America
Kaiser Permanente-San Diego Mission - Recruiting
San Diego, United States of America
Moffitt Cancer Center - McKinley Campus - Recruiting
Tampa, United States of America
Tacoma/Valley Radiation Oncology Centers-Saint Joe's - Suspended
Tacoma, United States of America
Radiation Oncology Centers of Nevada Central - Recruiting
Las Vegas, United States of America
Vanderbilt University/Ingram Cancer Center - Recruiting
Nashville, United States of America
Illinois CancerCare-Canton - Recruiting
Canton, United States of America
Cancer and Hematology Centers of Western Michigan - Norton Shores - Recruiting
Norton Shores, United States of America
University Medical Center of Southern Nevada - Recruiting
Las Vegas, United States of America
Illinois CancerCare-Kewanee Clinic - Recruiting
Kewanee, United States of America
Prisma Health Cancer Institute - Laurens - Recruiting
Clinton, United States of America
Yale-New Haven Hospital North Haven Medical Center - Recruiting
North Haven, United States of America
New Ulm Medical Center - Recruiting
New Ulm, United States of America
Mountain Blue Cancer Care Center - Suspended
Golden, United States of America
Utah Valley Regional Medical Center - Recruiting
Provo, United States of America
Kaiser Permanente-Anaheim - Recruiting
Anaheim, United States of America
Lehigh Valley Hospital-Cedar Crest - Recruiting
Allentown, United States of America
Temple University Hospital - Active, not recruiting
Philadelphia, United States of America
Atrium Medical Center-Middletown Regional Hospital - Recruiting
Franklin, United States of America
Mercy Medical Center-West Lakes - Recruiting
West Des Moines, United States of America
Sparrow Hospital - Recruiting
Lansing, United States of America
HealthCare Partners Medical Group Oncology/Hematology-San Martin - Suspended
Las Vegas, United States of America
Kaiser San Rafael-Gallinas - Recruiting
San Rafael, United States of America
Essentia Health Virginia Clinic - Recruiting
Virginia, United States of America
Carle Cancer Center - Recruiting
Urbana, United States of America
Clackamas Radiation Oncology Center - Recruiting
Clackamas, United States of America
Parkland Health Center-Bonne Terre - Suspended
Bonne Terre, United States of America
Dublin Methodist Hospital - Recruiting
Dublin, United States of America
Veterans Affairs Connecticut Healthcare System-West Haven Campus - Recruiting
West Haven, United States of America
Ascension Columbia Saint Mary's Hospital - Milwaukee - Recruiting
Milwaukee, United States of America
Delbert Day Cancer Institute at PCRMC - Recruiting
Rolla, United States of America
Saint Joseph London - Recruiting
London, United States of America
Saint Vincent Hospital Cancer Center at Oconto Falls - Recruiting
Oconto Falls, United States of America
American Fork Hospital / Huntsman Intermountain Cancer Center - Recruiting
American Fork, United States of America
Medical Center of Baton Rouge - Recruiting
Baton Rouge, United States of America
UPMC Cancer Centers - Arnold Palmer Pavilion - Active, not recruiting
Greensburg, United States of America
The Carle Foundation Hospital - Recruiting
Urbana, United States of America
Comprehensive Cancer Centers of Nevada-Horizon Ridge - Recruiting
Henderson, United States of America
Legacy Salmon Creek Hospital - Recruiting
Vancouver, United States of America
University of Kansas Cancer Center - Lee's Summit - Recruiting
Lee's Summit, United States of America
Illinois CancerCare-Ottawa Clinic - Recruiting
Ottawa, United States of America
Harrison HealthPartners Hematology and Oncology-Poulsbo - Recruiting
Poulsbo, United States of America
Marshfield Medical Center-EC Cancer Center - Recruiting
Eau Claire, United States of America
Norris Cotton Cancer Center-Manchester - Recruiting
Manchester, United States of America
University of Kansas Hospital-Westwood Cancer Center - Recruiting
Westwood, United States of America
The Medical Center of Aurora - Recruiting
Aurora, United States of America
Kootenai Cancer Center - Recruiting
Post Falls, United States of America
Ascension Southeast Wisconsin Hospital - Elmbrook Campus - Recruiting
Brookfield, United States of America
Rocky Mountain Cancer Centers-Midtown - Recruiting
Denver, United States of America
University of Kansas Health System Saint Francis Campus - Recruiting
Topeka, United States of America
Macomb Hematology Oncology PC - Recruiting
Warren, United States of America
Radiation Oncology Centers of Nevada Southeast - Recruiting
Las Vegas, United States of America
Memorial Hospital of South Bend - Recruiting
South Bend, United States of America
Fairbanks Memorial Hospital - Recruiting
Fairbanks, United States of America
Essentia Health - Jamestown Clinic - Recruiting
Jamestown, United States of America
Sutter Davis Hospital - Recruiting
Davis, United States of America
Mercy Health Perrysburg Cancer Center - Suspended
Perrysburg, United States of America
Helen DeVos Children's Hospital at Spectrum Health - Recruiting
Grand Rapids, United States of America
Saint Joseph Mercy Canton - Recruiting
Canton, United States of America
Las Vegas Urology - Smoke Ranch - Recruiting
Las Vegas, United States of America
Saint Joseph Mercy Chelsea - Recruiting
Chelsea, United States of America
Marshfield Clinic-Minocqua Center - Recruiting
Minocqua, United States of America
Baylor University Medical Center - Suspended
Dallas, United States of America
Alegent Health Mercy Hospital - Recruiting
Council Bluffs, United States of America
Sainte Genevieve County Memorial Hospital - Recruiting
Sainte Genevieve, United States of America
Bay Area Tumor Institute - Recruiting
Oakland, United States of America
Dayton Physician LLC-Miami Valley Hospital North - Recruiting
Dayton, United States of America
Oncology Associates at Mercy Medical Center - Recruiting
Cedar Rapids, United States of America
UC Comprehensive Cancer Center at Silver Cross - Recruiting
New Lenox, United States of America
Glens Falls Hospital - Recruiting
Glens Falls, United States of America
TriHealth Cancer Institute-Westside - Recruiting
Cincinnati, United States of America
Newland Medical Associates-Pontiac - Recruiting
Pontiac, United States of America
University of Kansas Cancer Center - Recruiting
Kansas City, United States of America
Saint Joseph Medical Center - Active, not recruiting
Bloomington, United States of America
Cancer Center of Kansas - McPherson - Recruiting
Mcpherson, United States of America
Greater Dayton Cancer Center - Recruiting
Kettering, United States of America
Tacoma/Valley Radiation Oncology Centers-Puyallup - Suspended
Puyallup, United States of America
Loyola Center for Cancer Care and Research - Recruiting
Orland Park, United States of America
UPMC-Magee Womens Hospital - Active, not recruiting
Pittsburgh, United States of America
Mercy Medical Center - Recruiting
Durango, United States of America
Allegheny General Hospital - Recruiting
Pittsburgh, United States of America
Memorial Hospital West - Recruiting
Pembroke Pines, United States of America
Baptist Memorial Hospital and Cancer Center-Memphis - Recruiting
Memphis, United States of America
Essentia Health - Deer River Clinic - Recruiting
Deer River, United States of America
Christiana Care Health System-Wilmington Hospital - Recruiting
Wilmington, United States of America
USC Norris Oncology/Hematology-Newport Beach - Recruiting
Newport Beach, United States of America
Western Illinois Cancer Treatment Center - Recruiting
Galesburg, United States of America
Saint Joseph Hospital - Orange - Recruiting
Orange, United States of America
Essentia Health Saint Mary's - Detroit Lakes Clinic - Recruiting
Detroit Lakes, United States of America
AdventHealth East Orlando - Active, not recruiting
Orlando, United States of America
Providence Cancer Institute Clackamas Clinic - Recruiting
Clackamas, United States of America
Sanford South University Medical Center - Recruiting
Fargo, United States of America
Great Lakes Cancer Management Specialists-Macomb Medical Campus - Recruiting
Macomb, United States of America
Bay Area Hospital - Recruiting
Coos Bay, United States of America
Dayton Physicians LLC-Miami Valley South - Recruiting
Centerville, United States of America
Hematology and Oncology Consultants PC - Suspended
Omaha, United States of America
Dayton Physicians LLC-Upper Valley - Recruiting
Troy, United States of America
Atlanta VA Medical Center - Recruiting
Decatur, United States of America
Katmai Oncology Group - Recruiting
Anchorage, United States of America
Prisma Health Cancer Institute - Greer - Recruiting
Greer, United States of America
Lewis Cancer and Research Pavilion at Saint Joseph's/Candler - Recruiting
Savannah, United States of America
Medical Oncology and Hematology Associates-Laurel - Recruiting
Des Moines, United States of America
National Jewish Health-Northern Hematology Oncology - Suspended
Thornton, United States of America
Valley Radiation Oncology - Recruiting
Peru, United States of America
Providence Regional Cancer Partnership - Recruiting
Everett, United States of America
Kuakini Medical Center - Recruiting
Honolulu, United States of America
Southeastern Medical Oncology Center-Jacksonville - Recruiting
Jacksonville, United States of America
Great Lakes Cancer Management Specialists-Doctors Park - Recruiting
East China Township, United States of America
Vanderbilt-Ingram Cancer Center Cool Springs - Recruiting
Franklin, United States of America
Sky Ridge Medical Center - Recruiting
Lone Tree, United States of America
Comprehensive Cancer Centers of Nevada - Northwest - Recruiting
Las Vegas, United States of America
Pottstown Hospital - Recruiting
Pottstown, United States of America
Las Vegas Cancer Center-Henderson - Recruiting
Henderson, United States of America
Memorial Medical Center - Las Cruces - Recruiting
Las Cruces, United States of America
Idaho Urologic Institute-Meridian - Recruiting
Meridian, United States of America
Mercy UC Davis Cancer Center - Active, not recruiting
Merced, United States of America
Palo Alto Medical Foundation Health Care - Recruiting
Palo Alto, United States of America
Genesee Cancer and Blood Disease Treatment Center - Recruiting
Flint, United States of America
Harbin Clinic Medical Oncology and Clinical Research - Recruiting
Rome, United States of America
Eastern Regional Medical Center - Recruiting
Philadelphia, United States of America
PeaceHealth United General Medical Center - Recruiting
Sedro-woolley, United States of America
Mercy Hospital - Recruiting
Cedar Rapids, United States of America
Poudre Valley Hospital - Active, not recruiting
Fort Collins, United States of America
Siteman Cancer Center at West County Hospital - Recruiting
Creve Coeur, United States of America
University Hospital - Active, not recruiting
San Antonio, United States of America
Highlands Oncology Group - Springdale - Recruiting
Springdale, United States of America
OptumCare Cancer Care at Charleston - Recruiting
Las Vegas, United States of America
Gibbs Cancer Center-Gaffney - Recruiting
Gaffney, United States of America
Epic Care Cyberknife Center - Recruiting
Walnut Creek, United States of America
Kaiser Permanente-Vallejo - Recruiting
Vallejo, United States of America
HSHS Saint Nicholas Hospital - Recruiting
Sheboygan, United States of America
University of Vermont Medical Center - Recruiting
Burlington, United States of America
McKay-Dee Hospital Center - Recruiting
Ogden, United States of America
Montefiore Medical Center-Weiler Hospital - Recruiting
Bronx, United States of America
Baptist Memorial Hospital and Cancer Center-Desoto - Recruiting
Southhaven, United States of America
Riverton Hospital - Recruiting
Riverton, United States of America
Rush University Medical Center - Recruiting
Chicago, United States of America
Ascension Saint Mary's Hospital - Recruiting
Saginaw, United States of America
21st Century Oncology-Henderson - Recruiting
Henderson, United States of America
Carle on Vermilion - Recruiting
Danville, United States of America
University of Kansas Cancer Center-West - Recruiting
Kansas City, United States of America
Ascension Medical Group Southeast Wisconsin - Mayfair Road - Recruiting
Wauwatosa, United States of America
Mercy Health Mercy Campus - Recruiting
Muskegon, United States of America
Ascension Saint Elizabeth Hospital - Recruiting
Appleton, United States of America
Saint Alphonsus Medical Center-Baker City - Recruiting
Baker City, United States of America
Gulfport Memorial Hospital - Recruiting
Gulfport, United States of America
Prisma Health Cancer Institute - Seneca - Recruiting
Seneca, United States of America
Good Samaritan Hospital - Cincinnati - Recruiting
Cincinnati, United States of America
Overlake Medical Center - Recruiting
Bellevue, United States of America
Providence Regional Cancer System-Centralia - Recruiting
Centralia, United States of America
Cancer Treatment Centers of America - Recruiting
Tulsa, United States of America
Legacy Cancer Institute Medical Oncology and Day Treatment - Recruiting
Vancouver, United States of America
Saints Mary and Elizabeth Hospital - Recruiting
Louisville, United States of America
Summerlin Hospital Medical Center - Recruiting
Las Vegas, United States of America
The Cancer Center of Hawaii-Pali Momi - Recruiting
'aiea, United States of America
Saint Joseph Regional Cancer Center - Recruiting
Bryan, United States of America
Moffitt Cancer Center-International Plaza - Recruiting
Tampa, United States of America
Swedish Cancer Institute-Edmonds - Recruiting
Edmonds, United States of America
Medical Oncology and Hematology Associates-Des Moines - Recruiting
Des Moines, United States of America
Saint Clare Hospital - Recruiting
Lakewood, United States of America
Kaiser Permanente-San Marcos - Recruiting
San Marcos, United States of America
21st Century Oncology-Vegas Tenaya - Recruiting
Las Vegas, United States of America
Sandra L Maxwell Cancer Center - Recruiting
Cedar City, United States of America
Comprehensive Cancer Centers of Nevada - Central Valley - Recruiting
Las Vegas, United States of America
Northwestern Medicine Cancer Center Kishwaukee - Recruiting
Dekalb, United States of America
Bhadresh Nayak MD PC-Sterling Heights - Recruiting
Sterling Heights, United States of America
Minnesota Oncology - Burnsville - Recruiting
Burnsville, United States of America
Oklahoma Cancer Specialists and Research Institute-Tulsa - Active, not recruiting
Tulsa, United States of America
Vidant Oncology-Richlands - Recruiting
Richlands, United States of America
Delaware Clinical and Laboratory Physicians PA - Recruiting
Newark, United States of America
Unity Hospital - Recruiting
Fridley, United States of America
Highlands Oncology Group PA - Fayetteville - Recruiting
Fayetteville, United States of America
Loyola University Medical Center - Recruiting
Maywood, United States of America
Memorial Regional Cancer Center Day Road - Suspended
Mishawaka, United States of America
The Cancer Center of Hawaii-Liliha - Recruiting
Honolulu, United States of America
Mercy Hematology and Oncology Associates Inc - Recruiting
Canton, United States of America
Heartland Hematology and Oncology - Suspended
Kearney, United States of America
Saint Elizabeth Boardman Hospital - Recruiting
Boardman, United States of America
Swedish Medical Center-Ballard Campus - Recruiting
Seattle, United States of America
Springmill Medical Center - Suspended
Indianapolis, United States of America
Las Vegas Cancer Center-Medical Center - Recruiting
Las Vegas, United States of America
Las Vegas Urology - Cathedral Rock - Recruiting
Las Vegas, United States of America
Kaiser Permanente-Woodland Hills - Recruiting
Woodland Hills, United States of America
Northwest Medical Specialties PLLC - Recruiting
Tacoma, United States of America
Capital Region Southwest Campus - Recruiting
Jefferson City, United States of America
Saint Anthony Hospital - Recruiting
Lakewood, United States of America
Boulder Community Hospital - Recruiting
Boulder, United States of America
Beebe Medical Center - Recruiting
Lewes, United States of America
ProMedica Flower Hospital - Recruiting
Sylvania, United States of America
MultiCare Gig Harbor Medical Park - Recruiting
Gig Harbor, United States of America
Las Vegas Urology - Pecos - Recruiting
Las Vegas, United States of America
Kaiser Permanente-San Francisco - Recruiting
San Francisco, United States of America
Eligibilities
Sex: All
Minimum Age: 18
Healthy Volunteers: No
Inclusion Criteria:
- Patients are eligible under ONE of the following criteria:
- For all cohorts except the gestational trophoblastic disease (GTD) (Cohort #47), patients must have histologically and/or biochemically confirmed rare cancer and must be able to submit specimens; to be eligible for the GTD cohort: patients must have disease confirmed by quantitative serum beta-human chorionic gonadotropin (hCG) within 28 days prior to registration and must be able to submit blood specimens (tissue submission is not required for patients who will be registered to the GTD cohort [Cohort #47]); NOTE: Subsequent to site's Institutional Review Board (IRB) approval of revision 3, patients are NOT required to participate in EAY131 National Cancer Institute (NCI)-Molecular Analysis for Therapy Choice (MATCH) to register to S1609 OR
- FOR PATIENTS WITH PD-L1 AMPLIFICATION (COHORT #50) ONLY: All solid tumors (excluding lymphoma) are allowed for the PD-L1 amplified cohort if they have PD-L1 amplification; patients may be considered for registration to the PD-L1 amplified cohort (Cohort #50) with the confirmation of at least one of the study chairs; PD-L1 amplification is defined as having deoxyribonucleic acid (DNA) copy number of equal to or greater than six by any of the following Clinical Laboratory Improvement Act (CLIA)-approved lab; (Immunohisochemistry [IHC] and fluorescence in situ hybridization [FISH] are not allowed); the assay must be done at or after the diagnosis of advanced disease, but PRIOR TO REGISTRATION; NOTE: patients with PD-L1 overexpression by IHC or PD-L1 amplification by FISH do not quality for this cohort; OR
- FOR PATIENTS ENROLLED IN EAY131 NCI-MATCH PRIOR TO EAY131 ADDENDUM 10 ONLY: Patients must have histologically confirmed rare cancer that did not have a match to a molecularly-guided therapy on EAY131 NCI-MATCH protocol or who are off protocol treatment on EAY131, NCI-MATCH and have no further molecularly-matched treatment recommendations per EAY131, NCI-MATCH or who are otherwise unable to receive EAY131, NCI-MATCH therapy
- Patients who do not qualify for one of the histologic cohorts and are not on the ineligible histology list may be considered for registration in the Not Otherwise Categorized Rare Tumors cohort with confirmation of at least one of the study chairs via email
- NOTE: The Not Otherwise Categorized Rare Tumors cohort was permanently closed to accrual on 3/15/2019
- Patients who are determined to have a rare cancer with unknown primary site are eligible under cohort #32 (tumor of unknown primary [cancer of unknown primary; CuP]), provided that there is histologic documentation of metastatic malignancy with no discernible primary site identified from histopathologic review, physical exam and associated cross-sectional imaging of the chest, abdomen, and pelvis
- NOTE: The Tumor of unknown primary (Cancer of Unknown Primary; CuP cohort was permanently closed to accrual on 12/22/2017
- Patients must also meet one of the following:
- Patients must have progressed following at least one line of standard systemic therapy and there must not be other approved/standard therapy available that has been shown to prolong overall survival (i.e. in a randomized trial against another standard treatment or by comparison to historical controls); patients who cannot receive other standard therapy that has been shown to prolonged survival due to medical issues will be eligible, if other eligibility criteria are met; OR
- Patients for whose disease no standard treatment exists that has been shown to prolong overall survival
- For all cohorts except the GTD cohort (Cohort #47): Patients must have a diagnostic quality computed tomography (CT) scan or magnetic resonance imaging (MRI), performed within 28 days prior to registration, which demonstrates measurable disease, as defined in RECIST v. 1.1; scans must include imaging of the chest, abdomen and pelvis, with the exception of patients with head/neck cancer, who must have imaging of the chest, abdomen, pelvis and neck; if there is clinical suspicion for bone metastases at the time of enrollment (in the judgement of the treating investigator) bone scan should be performed; bone scans done within 42 days prior to registration may be used to establish baseline condition at registration
- No other prior malignancy is allowed except for the following:
- Adequately managed stage I or II cancer from which the patient is currently in complete remission
- Any other cancer from which the patient has been disease free for one year
- Adequately managed stage I or II follicular thyroid or prostate cancer is also eligible, wherein patient is not required to be in complete remission
- Note: Second primary tumors are not allowed concurrent with any of the eligible rare cancers
- For all cohorts except the PD-L1 amplified tumors cohort (Cohort # 50): Patients may have received either prior anti-CTLA4 or other prior anti-PD-1/anti-PD-L1 therapy, but not both, provided that it is completed >= 4 weeks prior to registration. To be eligible for the PD-L1 amplified tumors cohort (Cohort #50): Patients must not have received anti-PD-1/anti-PD-L1 therapy; prior anti-CTLA-4 is allowed provided that it is completed >= 4 weeks prior to registration
- Patients with clinically controlled thyroiditis or pituitary disorders on stable replacement therapy are eligible
- Patients with autoimmune disease who are otherwise eligible must not have received steroid and immunosuppressive therapy within 28 days prior to registration
- Patients with brain metastases or primary brain tumors must have completed treatment, surgery or radiation therapy >= 28 days prior to registration and have stable disease at time of registration; these patients must also have a CT or MRI of the brain to evaluate for CNS disease within 42 days prior to registration to S1609; metastatic brain parenchymal disease must have been treated and patient must be off steroids for 7 days prior to registration
- Hormonal or endocrine blockade is permitted as long as patient has demonstrated progression on prior therapy (e.g. gonadotrophin releasing hormone [GnRH], somatostatin); long-acting somatostatin analogs (including octreotide) and androgen deprivation treatment (including long-acting leuprolide) are permitted while on protocol therapy
- Patients must have a Zubrod performance status of 0-2
- Absolute neutrophil count (ANC) >= 1,000/mcL (within 28 days prior to registration)
- Platelets >= 75,000/mcL (within 28 days prior to registration)
- Hemoglobin >= 8 g/dL (within 28 days prior to registration)
- Total bilirubin =< 2.0 x institutional upper limit of normal (IULN) or for documented/suspected Gilbert's disease, total bilirubin =< 3.0 x IULN (within 28 days prior to registration)
- Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) both =< 3 x IULN (within 28 days prior to registration)
- Serum creatinine =< 2.0 x IULN (within 28 days prior to registration)
- Creatinine clearance (CrCl) >= 50 mL/min., as estimated by the Cockcroft and Gault formula; estimated creatinine clearance is based on actual body weight (within 28 days prior to registration)
- Patients must have adequate thyroid function, as evidenced by either thyroid-stimulating hormone (TSH) or, free thyroxine (T4) serum tests demonstrating values within the normal range, within 28 days prior to registration; at pre-registration, if TSH is not within normal limits, then free T4 must be performed and must be within normal range for patient to be eligible; Note: TSH, with reflex T4 (if TSH is abnormal) is allowable if per institutional standard, provided that free T4 is within normal range; patients who have undergone thyroidectomy or who are on thyroid suppression for their cancer are not required to have normal TSH and free T4
- Patients must have adequate adrenal axis function, as evidenced by cortisol levels within institutional normal ranges (ante meridiem [AM] cortisol preferred), OR adrenocorticotropic hormone (ACTH) values within the institutional normal ranges within 28 days prior to registration; if cortisol levels are not within normal limits prior to registration, then ACTH must be performed and must be within normal ranges for patient to be eligible; Note: Neither cortisol nor ACTH levels are required for patients with primary adrenal tumors (e.g. adrenocortical carcinoma)
- For women of childbearing potential, the local investigator must rule out pregnancy; Except for Cohorts 13 and 47, where tumor types may express beta-hCG, women of childbearing potential must have a serum or urine pregnancy test within 7 days prior to registration; for Cohorts 13 and 47, where tumor types may produce hCG (e.g. germ cell tumors or trophoblastic disease), other pregnancy exclusion methods should be used to rule out pregnancy, such as ultrasound examination, documented history of effective contraception, or documented infertility; all females of childbearing potential must have been demonstrated not to be pregnant within 7 days prior to registration and agree to use birth control throughout study and for 23 weeks after completion of protocol therapy; patients must not be pregnant or nursing due to risk of fetal or nursing infant harm; women of childbearing potential must have agreed to use an effective contraceptive method; a woman is considered to be of childbearing potential if she has had menses at any time in the preceding 12 consecutive months; in addition to routine contraceptive methods, effective contraception also includes heterosexual celibacy and surgery intended to prevent pregnancy (or with a side-effect of pregnancy prevention) defined as a hysterectomy, bilateral oophorectomy or bilateral tubal ligation; however, if at any point a previously celibate patient chooses to become heterosexually active during the time period for use of contraceptive measures outlined in the protocol, she is responsible for beginning contraceptive measures
- Men of reproductive potential must have agreed to use birth control throughout the study and for 31 weeks after completion of protocol therapy; in addition to routine contraceptive methods, effective contraception also includes heterosexual celibacy and surgery intended to prevent pregnancy (vasectomy); however, if at any point a previously celibate patient chooses to become heterosexually active during the time period for use of contraceptive measures outlined in the protocol, he is responsible for beginning contraceptive measures
- Patients who are known to be human immunodeficiency virus (HIV)-positive at registration are eligible at the time of registration:
- CD4+ cell count greater or equal to 250 cells/mm^3
- No history of non-malignancy acquired immunodeficiency syndrome (AIDS)-defining conditions other than historical low CD4+ cell counts
- Patients must have amylase or lipase within =< 1.5 x IULN without symptoms of pancreatitis at registration, within 28 days prior to registration
- Patients must have fully recovered from any adverse effects of major surgery (to =< grade 1) at least 14 days prior to registration
Exclusion Criteria:
- Patients who had prior grade 3 or higher immune-related adverse event (e.g. pneumonitis, hepatitis, colitis, endocrinopathy) with prior immunotherapy (e.g. cancer vaccine, cytokine, etc.) are not eligible
- Patients are not eligible if they have had or are planned for solid organ transplant
- Patients must not currently be receiving any other investigational agents or any other systemic anti-cancer therapy (including radiation, excluding RANKL inhibitors and bisphosphonates); in event patient recently received any other systemic anti-cancer therapy, patient must be off therapy at least 7 days prior to registration and any therapy-induced toxicity must have recovered to =< grade 1, except alopecia and =< grade 2 neuropathy which are allowed; any planned radiation therapy must be completed before registration to S1609
- Patients must not have prior history of allergy or known hypersensitivity to nivolumab or ipilimumab
- Patients must not have known active hepatitis B virus (HBV) or hepatitis virus (HCV) infection at time of registration; patients with HBV or HCV that have an undetectable viral load and no residual hepatic impairment are eligible
- Patients must not have active autoimmune disease that has required systemic treatment in past 2 years (i.e., with use of disease modifying agents, immunosuppressive drugs, or corticosteroids with prednisone dose >= 10 mg); replacement therapy (e.g., thyroxine, insulin, or physiologic corticosteroid replacement therapy for adrenal or pituitary insufficiency, etc.) is not considered a form of systemic treatment; autoimmune diseases include but are not limited to autoimmune hepatitis, inflammatory bowel disease (including ulcerative colitis and Crohn's disease), as well as symptomatic disease (e.g.: rheumatoid arthritis, systemic progressive sclerosis [scleroderma], systemic lupus erythematosus, autoimmune vasculitis [e.g., Wegener's granulomatosis]); central nervous system (CNS) or motor neuropathy considered of autoimmune origin (e.g., Guillain-Barre syndrome and Myasthenia gravis, multiple sclerosis or glomerulonephritis); vitiligo, alopecia, hypothyroidism on stable doses of thyroid replacement therapy, psoriasis not requiring systemic therapy within the past 2 years is permitted; short-term steroid premedication for contrast allergy is permitted
- Patients must not have any uncontrolled intercurrent illness including (not limited to): symptomatic congestive heart failure (CHF) (New York Heart Association [NYHA] III/IV), unstable angina pectoris or coronary angioplasty, or stenting within 24 weeks prior to registration, unstable cardiac arrhythmia (ongoing cardiac dysrhythmias of NCI Common Terminology Criteria for Adverse Events [CTCAE] version [v] 4 grade >= 2), known psychiatric illness that would limit study compliance, intra-cardiac defibrillators, known cardiac metastases, or abnormal cardiac valve morphology (>= grade 3)
- Note: Patients with history of CHF or patients who are deemed at risk because of underlying cardiovascular disease or exposure to cardiotoxic drugs should have an electrocardiogram (EKG) and echocardiogram (ECHO), as clinically indicated, at baseline and at the start of each cycle; patients who have evidence at baseline (or subsequently) of CHF, myocardial infarction (MI), cardiomyopathy, or myositis cardiac evaluation (NYHA I/II) should have additional consult by a cardiologist, including review of EKG, creatine phosphokinase (CPK), troponin, echocardiogram, as clinically indicated
- Patients must not have symptomatic interstitial lung disease or pneumonitis
Relevant Conditions

Acinic Cell Carcinoma of Salivary Glands, Adenoid Cystic Carcinoma, Adrenal Cancer, Adrenal Gland Adenoma, Adrenocortical Carcinoma, Adult Soft Tissue Sarcoma, Anaplastic Thyroid Cancer, Angiosarcoma, Basal Cell Skin Cancer, Cervical Cancer, Chordoma, Choriocarcinoma, Desmoid Tumor, Endometrial Cancer, Extramammary Paget Disease, Familial Pancreatic Cancer, Familial Prostate Cancer, Fibromatosis, Fibrosarcoma, Gallbladder Cancer, Gastrointestinal Stromal Tumor, Gestational Trophoblastic Disease, Head and Neck Squamous Cell Carcinoma, Lung Adenocarcinoma, Lung Cancer, Malignant Germ Cell Tumor, Malignant Mesothelioma, Malignant Peripheral Nerve Sheath Tumor, Malignant Teratoma of the Mediastinum, Nasopharyngeal Carcinoma, Neuroendocrine Tumor, Ovarian Cancer, Ovarian Carcinosarcoma, Paget Disease of the Breast, Paget's Disease of Bone, Pancreatic Adenoma, Pancreatic Cancer, Pancreatic Islet Cell Tumor, Parathyroid Cancer, Pheochromocytoma, Prostate Cancer, Pseudomyxoma Peritonei, Renal Oncocytoma, Schwannoma, Small Cell Lung Cancer, Squamous Cell Lung Carcinoma, Squamous Cell Skin Carcinoma, Testicular Cancer, Thyroid Cancer, Urothelial Cancer, Vulvar Cancer

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